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Immunology

D-Index
46
Citations
9943
World Ranking
4593
National Ranking
2071

Research.com Recognitions

  • 1993 - Fellow of the American Phytopathological Society

Overview

Don M. Benson is affiliated with The Ohio State University in the United States and has a research focus primarily within the field of Medicine, with specialization in Hematology, Molecular Biology, Oncology, Transplantation, and Public Health, Environmental and Occupational Health. Their work spans multiple topics including Multiple Myeloma Research and Treatments, Hematopoietic Stem Cell Transplantation, Renal Transplantation Outcomes and Treatments, Acute Lymphoblastic Leukemia research, Protein Degradation and Inhibitors, Peptidase Inhibition and Analysis, and Acute Myeloid Leukemia Research.

Benson has contributed to numerous publications with frequent outlets including Blood, Transplantation and Cellular Therapy, Biology of Blood and Marrow Transplantation, Journal of Clinical Oncology, and Cancers.

The recent research papers authored or co-authored by Benson include:

  • Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function, 2021, JCI Insight
  • Aging Phenotypes and Restoring Functional Deficits in Older Adults With Hematologic Malignancy, 2021, Journal of the National Comprehensive Cancer Network
  • Effect of Early Post-Transplantation Tacrolimus Concentration on the Risk of Acute Graft-Versus-Host Disease in Allogenic Stem Cell Transplantation, 2021, Cancers
  • Characterizing inclusion and exclusion criteria in clinical trials for chimeric antigen receptor (CAR) T-cell therapy among adults with hematologic malignancies, 2020, Journal of Geriatric Oncology
  • Real World Experience of Daratumumab: Evaluating Lymphopenia and Adverse Events in Multiple Myeloma Patients, 2021, Frontiers in Oncology

Frequent co-authors collaborating with Benson are Ashley Rosko, Srinivas Devarakonda, Naresh Bumma, Yvonne A. Efebera, and Nidhi Sharma.

The scientist's work covers a range of subfields related to blood cancers, transplantation, and molecular mechanisms underlying disease and treatment responses. Their research includes focus areas such as early post-transplantation immunosuppression, functional deficits in older adults with hematologic malignancies, and immune regulation within tumor microenvironments.

Benson was honored as a Fellow of the American Phytopathological Society in 1993, indicating recognition within the scientific community.

Best Publications

  • The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti–PD-1 antibody

    Don M. Benson;Courtney E. Bakan;Anjali Mishra;Craig C. Hofmeister

  • Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia.

    Jennifer R. Brown;John C. Byrd;Steven E. Coutre;Don M. Benson

  • Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development

    Flavia Pichiorri;Flavia Pichiorri;Sung Suk Suh;Sung Suk Suh;Alberto Rocci;Luciana De Luca

  • CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma

    Jianhong Chu;Youcai Deng;Don M. Benson;Shun He

  • Preclinical characterization of 1-7F9, a novel human anti–KIR receptor therapeutic antibody that augments natural killer–mediated killing of tumor cells

    Francois Romagné;Pascale André;Pieter Spee;Stefan Zahn

  • Elotuzumab directly enhances NK cell cytotoxicity against myeloma via CS1 ligation: evidence for augmented NK cell function complementing ADCC

    Shauna M. Collins;Courtney E. Bakan;Gina D. Swartzel;Craig C. Hofmeister

  • Pro- and Antiinflammatory Cytokine Signaling: Reciprocal Antagonism Regulates Interferon-gamma Production by Human Natural Killer Cells

    Jianhua Yu;Min Wei;Brian Becknell;Rossana Trotta

  • The Mechanism of Anti-PD-L1 Antibody Efficacy against PD-L1-Negative Tumors Identifies NK Cells Expressing PD-L1 as a Cytolytic Effector.

    Wenjuan Dong;Xiaojin Wu;Xiaojin Wu;Shoubao Ma;Shoubao Ma;Yufeng Wang

  • A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission

    Norbert Vey;Jean-Henri Bourhis;Nicolas Boissel;Dominique Bordessoule

  • Phase I Trial of Anti-CS1 Monoclonal Antibody Elotuzumab in Combination With Bortezomib in the Treatment of Relapsed/Refractory Multiple Myeloma

    Andrzej J. Jakubowiak;Don M. Benson;William Bensinger;David S.D. Siegel

  • A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma.

    Don M. Benson;Craig C. Hofmeister;Swaminathan Padmanabhan;Attaya Suvannasankha

  • IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect.

    Don M. Benson;Courtney E. Bakan;Shuhong Zhang;Shauna M. Collins

  • Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-δ, as therapy for previously treated indolent non-Hodgkin lymphoma.

    Ian W. Flinn;Brad S. Kahl;John P. Leonard;Richard R. Furman

  • A phase 1b study of isatuximab plus lenalidomide and dexamethasone for relapsed/refractory multiple myeloma.

    Thomas Martin;Rachid Baz;Don M. Benson;Nikoletta Lendvai;Nikoletta Lendvai

  • CAL-101, An Isoform-Selective Inhibitor of Phosphatidylinositol 3-Kinase P110δ, Demonstrates Clinical Activity and Pharmacodynamic Effects In Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia

    Richard R. Furman;John C. Byrd;Jennifer R Brown;Steven E. Coutre

  • A phase I trial of the anti-KIR antibody IPH2101 and lenalidomide in patients with relapsed/refractory multiple myeloma

    Don M. Benson;Adam D. Cohen;Sundar Jagannath;Nikhil C. Munshi

  • A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells

    Li Lin;Li Lin;Stephanie Deangelis;Elizabeth Foust;James Fuchs

  • Clinical Safety and Activity In a Phase 1 Study of CAL-101, An Isoform-Selective Inhibitor of Phosphatidylinositol 3-Kinase P110δ, In Patients with Relapsed or Refractory Non-Hodgkin Lymphoma

    Brad Kahl;John C. Byrd;Ian W. Flinn;Nina Wagner-Johnston

  • The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.

    Matthew A. Bill;James R. Fuchs;Chenglong Li;Jennifer Yui

  • CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody

    Farrukh T. Awan;Rosa Lapalombella;Rossana Trotta;Jonathan P. Butchar

  • Fratricide of NK Cells in Daratumumab Therapy for Multiple Myeloma Overcome by Ex Vivo–Expanded Autologous NK Cells

    Yufeng Wang;Yibo Zhang;Tiffany Hughes;Jianying Zhang

  • A Phase 2 Study of Rituximab in Combination with Recombinant Interleukin-2 for Rituximab-Refractory Indolent Non-Hodgkin's Lymphoma

    Khuda D. Khan;Christos Emmanouilides;Don M. Benson;Deborah Hurst

  • The Transcription Factor AHR Prevents the Differentiation of a Stage 3 Innate Lymphoid Cell Subset to Natural Killer Cells

    Tiffany Hughes;Edward L. Briercheck;Aharon G. Freud;Rossana Trotta

Frequent Co-Authors

Steven M. Devine
Steven M. Devine The Ohio State University
John C. Byrd
John C. Byrd University of Pittsburgh Cancer Institute
Michael A. Caligiuri
Michael A. Caligiuri City Of Hope National Medical Center
Jianhua Yu
Jianhua Yu City Of Hope National Medical Center
Richard R. Furman
Richard R. Furman NewYork–Presbyterian Hospital
Jennifer R. Brown
Jennifer R. Brown Harvard University
Ian W. Flinn
Ian W. Flinn Sarah Cannon Research Institute
Guido Marcucci
Guido Marcucci City Of Hope National Medical Center
Michael R. Grever
Michael R. Grever The Ohio State University
Steven Coutre
Steven Coutre Stanford University

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