Michael W. Hunkapiller

Pacific Biosciences (United States)
United States

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name Citations Publications World Ranking National Ranking

Biology and Biochemistry D-index 58 Citations 24,941 118 World Ranking 8652 National Ranking 3891

Research.com Recognitions

Awards & Achievements

2008 - Member of the National Academy of Engineering For the invention and commercialization of DNA and protein sequencers and DNA synthesizers that have revolutionized comparative genetics and the mapping of the human genome.

1991 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is he best known for?

The fields of study he is best known for:

Gene
DNA
Enzyme

Michael W. Hunkapiller spends much of his time researching Peptide sequence, Chromatography, Biochemistry, Genetics and Genome. His research in Peptide sequence intersects with topics in Receptor, Autoanalysis and Molecular biology. His Chromatography research integrates issues from Gel electrophoresis, Edman degradation and Peptide.

His work on Genome project, Reference genome and Comparative genomics is typically connected to Sequence-tagged site as part of general Genetics study, connecting several disciplines of science. His Genome study frequently draws connections between related disciplines such as Computational biology. In his study, Amino acid is strongly linked to Myoglobin, which falls under the umbrella field of High-performance liquid chromatography.

His most cited work include:

The sequence of the human genome. (10608 citations)
A gas-liquid solid phase peptide and protein sequenator. (1871 citations)
Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor (1274 citations)

What are the main themes of his work throughout his whole career to date?

Michael W. Hunkapiller mainly investigates Biochemistry, Amino acid, Chromatography, Peptide sequence and Peptide. His Amino acid research is multidisciplinary, incorporating perspectives in Amino terminal, Cleavage, Interferon and Stereochemistry. The Chromatography study combines topics in areas such as Gel electrophoresis and Fluorescence.

His studies deal with areas such as Molecular biology and Sequence analysis as well as Peptide sequence. His research investigates the connection with Peptide and areas like Reagent which intersect with concerns in Combinatorial chemistry. His DNA sequencing research is multidisciplinary, incorporating elements of Genome and Human genome.

He most often published in these fields:

Biochemistry (34.29%)
Amino acid (23.57%)
Chromatography (22.86%)

What were the highlights of his more recent work (between 1994-2020)?

Computational biology (11.43%)
Genome (6.43%)
Human genome (5.71%)

In recent papers he was focusing on the following fields of study:

Michael W. Hunkapiller mostly deals with Computational biology, Genome, Human genome, Genetics and Sequence assembly. His Computational biology study combines topics from a wide range of disciplines, such as Molecular biology, Nucleic acid and Genomics. The various areas that he examines in his Human genome study include Structural variation, Base sequence, Shotgun sequencing and Tandem repeat.

His work on Hybrid genome assembly, Reference genome and Genome project as part of general Genetics study is frequently connected to Sequence-tagged site and SNP, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. His Sequence-tagged site research overlaps with Gene density, Genome size and Genome evolution. His research integrates issues of Texas Red, Gel electrophoresis and Fluorescein in his study of DNA sequencing.

Between 1994 and 2020, his most popular works were:

The sequence of the human genome. (10608 citations)
The Sequence of the Human Genome (1128 citations)
Resolving the complexity of the human genome using single-molecule sequencing (553 citations)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The Sequence of the Human Genome

J. Craig Venter;Mark D. Adams;Eugene W. Myers;Peter W. Li.
Clinical Chemistry (2015)

2923 Citations

A gas-liquid solid phase peptide and protein sequenator.

Rodney M. Hewick;Michael W. Hunkapiller;Leroy E. Hood;William J. Dreyer.
Journal of Biological Chemistry (1981)

2588 Citations

Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor

Russell F. Doolittle;Michael W. Hunkapiller;Leroy E. Hood;Sushilkumar G. Devare.
Science (1983)

1994 Citations

Dynorphin-(1-13), an extraordinarily potent opioid peptide

Avram Goldstein;S. Tachibana;L. I. Lowney;M. Hunkapiller.
Proceedings of the National Academy of Sciences of the United States of America (1979)

1374 Citations

Isolation of Microgram Quantities of Proteins From Polyacrylamide Gels for Amino Acid Sequence Analysis

Michael W. Hunkapiller;Eva Lujan;Frank Ostrander;Leroy E. Hood.
Methods in Enzymology (1983)

1337 Citations

High-sensitivity sequencing with a gas-phase sequenator.

Michael W. Hunkapiller;Rodney M. Hewick;William J. Dreyer;Leroy E. Hood.
Methods in Enzymology (1983)

935 Citations

Rat transforming growth factor type 1: structure and relation to epidermal growth factor

Hans Marquardt;Michael W. Hunkapiller;Leroy E. Hood;George J. Todaro.
Science (1984)

903 Citations

Acetylcholine receptor: complex of homologous subunits

Michael A. Raftery;Michael W. Hunkapiller;Catherine D. Strader;Leroy E. Hood.
Science (1980)

805 Citations

Resolving the complexity of the human genome using single-molecule sequencing

Mark J. P. Chaisson;John Huddleston;Megan Y. Dennis;Peter H. Sudmant.
Nature (2015)

717 Citations

Detection of specific sequences in nucleic acids

Norman M. Whiteley;Michael W. Hunkapiller;Alexander N. Glazer.
(1985)

649 Citations

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Frequent Co-Authors

External Links

Personal Website for Michael W. Hunkapiller