What is he best known for?
The fields of study he is best known for:
His primary scientific interests are in Immunology, Transforming growth factor beta, Transforming growth factor, Cytokine and Cancer research.
His Immunology study integrates concerns from other disciplines, such as Cytotoxic T cell and Interleukin 12.
His Transforming growth factor beta research integrates issues from IL-2 receptor, Molecular biology, Knockout mouse and Antibody, Anti-SSA/Ro autoantibodies.
Transforming growth factor is a subfield of Cell biology that John J. Letterio explores.
His Cytokine study also includes fields such as
- Dendritic cell, which have a strong connection to Lymphokine, Antigen presentation, Paracrine signalling, CCL18 and Epidermis,
- Cellular differentiation that intertwine with fields like Cell culture, Cell growth and Microglia.
He works mostly in the field of Cancer research, limiting it down to topics relating to Carcinogenesis and, in certain cases, Receptor, Genetically modified mouse, Endocrinology and Plasma cell.
His most cited work include:
- REGULATION OF IMMUNE RESPONSES BY TGF-β* (1712 citations)
- TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells (845 citations)
- Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. (815 citations)
What are the main themes of his work throughout his whole career to date?
His main research concerns Immunology, Cancer research, Cell biology, Transforming growth factor and Transforming growth factor beta.
His Cancer research research is multidisciplinary, incorporating perspectives in Cell culture, Carcinogenesis, Cancer, Cell growth and Bone marrow.
His study in Cell biology is interdisciplinary in nature, drawing from both R-SMAD, Cellular differentiation and Gene isoform.
His work in Transforming growth factor addresses subjects such as Receptor, which are connected to disciplines such as Genetically modified mouse and Cell.
His Transforming growth factor beta research also works with subjects such as
- Cytokine, which have a strong connection to Dendritic cell,
- Molecular biology that intertwine with fields like Gene expression.
His work in the fields of T cell, such as Interleukin 21, overlaps with other areas such as Cyclin-dependent kinase 5.
He most often published in these fields:
- Immunology (40.88%)
- Cancer research (36.48%)
- Cell biology (25.16%)
What were the highlights of his more recent work (between 2016-2020)?
- Cancer research (36.48%)
- T cell (22.01%)
- Immunology (40.88%)
In recent papers he was focusing on the following fields of study:
John J. Letterio mostly deals with Cancer research, T cell, Immunology, Bone marrow and Breast milk.
John J. Letterio interconnects Chemotherapy, Antibody-dependent cell-mediated cytotoxicity, Multiple myeloma, Bortezomib and Transforming growth factor beta in the investigation of issues within Cancer research.
His Transforming growth factor beta study combines topics from a wide range of disciplines, such as Ixazomib, Carfilzomib and Proteasome.
The various areas that John J. Letterio examines in his T cell study include Tumor necrosis factor alpha, Colitis and Effector.
In the subject of general Immunology, his work in Immune system and Experimental autoimmune encephalomyelitis is often linked to Cyclin-dependent kinase 5, thereby combining diverse domains of study.
The study incorporates disciplines such as Postpartum period, Internal medicine and Endocrinology in addition to Breast milk.
Between 2016 and 2020, his most popular works were:
- A unique tolerizing dendritic cell phenotype induced by the synthetic triterpenoid CDDO-DFPA (RTA-408) is protective against EAE. (10 citations)
- A unique tolerizing dendritic cell phenotype induced by the synthetic triterpenoid CDDO-DFPA (RTA-408) is protective against EAE. (10 citations)
- GHB levels in breast milk of women with narcolepsy with cataplexy treated with sodium oxybate. (10 citations)
In his most recent research, the most cited papers focused on:
His primary areas of study are Cancer research, T cell, Tumor necrosis factor alpha, Antibody and Combination therapy.
His Cancer research study combines topics in areas such as Haematopoiesis, Bone marrow failure, Stem cell and Aplastic anemia, Bone marrow.
Research on Immunology and Immune system is a part of his T cell study.
The Tumor necrosis factor alpha study combines topics in areas such as Encephalomyelitis and Signal transduction.
His research integrates issues of Receptor, Chemotherapy and Cell growth in his study of Antibody.
Many of his studies involve connections with topics such as Cell and Combination therapy.
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