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Immunology

D-Index
63
Citations
22487
World Ranking
2980
National Ranking
1402

Overview

John J. Letterio is affiliated with Case Western Reserve University in the United States. Their research primarily focuses on medicine and the intersecting disciplines of biochemistry, genetics, and molecular biology. Among their explored subfields are molecular biology, oncology, immunology, hematology, and artificial intelligence.

The scientist's recent scholarly contributions include studies on COVID-19 epidemiology and its broader pandemic impacts, childhood cancer survivors' quality of life, genetic factors in colorectal cancer, cancer immunotherapy and biomarkers, as well as topics involving genomics, phytochemicals, oxidative stress, and glutathione transferases and polymorphisms.

Recent papers authored or coauthored by John J. Letterio include:

  • Estimating the prevalence and risk of COVID-19 among international travelers and evacuees of Wuhan through modeling and case reports, 2020, PLoS ONE
  • Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4, 2020, OncoImmunology
  • Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss, 2023, Metabolism
  • Smad4-deficient T cells promote colitis-associated colon cancer via an IFN-γ-dependent suppression of 15-hydroxyprostaglandin dehydrogenase, 2022, Frontiers in Immunology
  • Modeling and Predicting Antibody Durability for mRNA-1273 Vaccine for SARS-CoV-2 Variants, 2021, bioRxiv (Cold Spring Harbor Laboratory)

Their frequent collaborators include researchers such as George Luo, Byung-Gyu Kim, Alex Y. Huang, Sung Hee Choi, and Toby Chen.

John J. Letterio's work has been published in various scientific venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS ONE
  • OncoImmunology
  • Metabolism
  • Frontiers in Immunology

Best Publications

  • REGULATION OF IMMUNE RESPONSES BY TGF-β*

    John James Letterio;Anita B. Roberts

  • TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

    Julien C. Marie;John James Letterio;Marc Gavin;Alexander Y. Rudensky

  • Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response.

    Gillian S. Ashcroft;Xiao Yang;Adam B. Glick;Michael Weinstein

  • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β

    Xiao Yang;John J. Letterio;Robert J. Lechleider;Lin Chen

  • CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

    Ciriaco A. Piccirillo;John J. Letterio;Angela M. Thornton;Rebecca S. McHugh

  • Transforming Growth Factor-β Production and Myeloid Cells Are an Effector Mechanism through Which CD1d-restricted T Cells Block Cytotoxic T Lymphocyte–mediated Tumor Immunosurveillance Abrogation Prevents Tumor Recurrence

    Masaki Terabe;So Matsui;Jong-Myun Park;Mizuko Mamura

  • A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells

    Teresa A. Borkowski;John J. Letterio;Andrew G. Farr;Mark C. Udey

  • Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance

    Stephanie Dillon;Sudhanshu Agrawal;Kaustuv Banerjee;John Letterio

  • Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

    Yu An Yang;Oksana Dukhanina;Binwu Tang;Mizuko Mamura

  • IL-13 Activates a Mechanism of Tissue Fibrosis That Is Completely TGF-β Independent

    Mallika Kaviratne;Matthias Hesse;Mary Leusink;Allen W. Cheever

  • Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis.

    Marika C. Kullberg;Dragana Jankovic;Peter L. Gorelick;Patricia Caspar

  • A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity

    Nanjoo Suh;Yongping Wang;Tadashi Honda;Gordon W. Gribble

  • Smad4 signalling in T cells is required for suppression of gastrointestinal cancer

    Byung Gyu Kim;Cuiling Li;Wenhui Qiao;Mizuko Mamura

  • Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity

    R. Dixon Dorand;Joseph Nthale;Joseph Nthale;Jay T. Myers;Jay T. Myers;Deborah S. Barkauskas;Deborah S. Barkauskas

  • Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production.

    Robert A. Seder;Thomas Marth;Myra C. Sieve;Warren Strober

  • Autoimmunity associated with TGF-β1-deficiency in mice is dependent on MHC class II antigen expression

    John J. Letterio;Andrew G. Geiser;Ashok B. Kulkarni;Howard Dang

  • Biology of TGF-β in knockout and transgenic mouse models

    Erwin P. Böttinger;John J. Letterio;Anita B. Roberts

  • SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF-beta knockout mice.

    Howard Dang;Andrew G. Geiser;John J. Letterio;Toru Nakabayashi

  • Targeting Improves MSC Treatment of Inflammatory Bowel Disease

    In Kap Ko;Byung Gyu Kim;Amad Awadallah;Jenifer Mikulan

  • Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype

    Andrew G. Geiser;John J. Letterio;Ashok B. Kulkarni;Stefan Karlsson

Frequent Co-Authors

Anita B. Roberts
Anita B. Roberts National Institutes of Health
Michael B. Sporn
Michael B. Sporn Dartmouth College
Ashok B. Kulkarni
Ashok B. Kulkarni National Institutes of Health
Eric Lam
Eric Lam Sun Yat-sen University
Marcos de Lima
Marcos de Lima The Ohio State University
Kathleen C. Flanders
Kathleen C. Flanders National Institutes of Health
Seong-Jin Kim
Seong-Jin Kim Seoul National University
Yoram Vodovotz
Yoram Vodovotz University of Pittsburgh
Chu-Xia Deng
Chu-Xia Deng University of Macau
Peter D. Aplan
Peter D. Aplan National Institutes of Health

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