Hartmut Kühn

What is he best known for?

The fields of study he is best known for:

• Enzyme
• Gene
• Amino acid

His scientific interests lie mostly in Biochemistry, Lipoxygenase, Enzyme, Cell biology and Phospholipid-hydroperoxide glutathione peroxidase. His study in Arachidonic acid, Metabolism, Low-density lipoprotein, Amino acid and Fatty acid is done as part of Biochemistry. The concepts of his Lipoxygenase study are interwoven with issues in Linoleic acid, Lipid peroxidation, Oxidative phosphorylation, Substrate and Isozyme.

His Enzyme study integrates concerns from other disciplines, such as Protein structure, Structural biology, Cholesterol and Complementary DNA. His research in Cell biology intersects with topics in Regulation of gene expression, Transdifferentiation, Granulocyte macrophage colony-stimulating factor and Gene isoform. His work deals with themes such as GPX4, GPX3, Hippocampus and GPX1, which intersect with Phospholipid-hydroperoxide glutathione peroxidase.

His most cited work include:

• Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase (329 citations)
• Inflammation and immune regulation by 12/15-lipoxygenases. (305 citations)
• Mammalian lipoxygenases and their biological relevance. (255 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Biochemistry, Lipoxygenase, Enzyme, Arachidonic acid and Stereochemistry. His study in Biochemistry concentrates on Amino acid, Active site, ALOX15, Metabolism and Membrane. His Lipoxygenase research is multidisciplinary, relying on both Linoleic acid, Fatty acid, Reticulocyte, Chromatography and Substrate.

His work carried out in the field of Enzyme brings together such families of science as Structural biology and Gene, Mutant. His Stereochemistry research incorporates elements of Hydrogen atom abstraction, Mutagenesis, Catalysis and Ebselen. His research investigates the link between Regulation of gene expression and topics such as Cell biology that cross with problems in Molecular biology.

He most often published in these fields:

• Biochemistry (53.14%)
• Lipoxygenase (52.72%)
• Enzyme (30.96%)

What were the highlights of his more recent work (between 2016-2021)?

• Biochemistry (53.14%)
• Lipoxygenase (52.72%)
• Enzyme (30.96%)

In recent papers he was focusing on the following fields of study:

Hartmut Kühn focuses on Biochemistry, Lipoxygenase, Enzyme, Arachidonic acid and ALOX15. The Lipoxygenase study combines topics in areas such as Inflammation, Mutant, Pseudomonas aeruginosa, Zebrafish and Oxygenation. Hartmut Kühn combines subjects such as Amino acid, Lipid oxidation, Catalysis and Molecular mechanics with his study of Enzyme.

His Arachidonic acid research includes themes of Lipid signaling, Linoleic acid, Fatty acid, Eicosapentaenoic acid and ALOX15B. His work in Linoleic acid covers topics such as Mutagenesis which are related to areas like Stereochemistry. His studies in ALOX15 integrate themes in fields like Genome, Colitis, Pharmacology and Polyunsaturated fatty acid.

Between 2016 and 2021, his most popular works were:

• Mammalian ALOX15 orthologs exhibit pronounced dual positional specificity with docosahexaenoic acid. (32 citations)
• The crystal structure of Pseudomonas aeruginosa lipoxygenase Ala420Gly mutant explains the improved oxygen affinity and the altered reaction specificity. (14 citations)
• The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs. (13 citations)

In his most recent research, the most cited papers focused on:

• Enzyme
• Gene
• Amino acid

His main research concerns ALOX15, Biochemistry, Enzyme, Arachidonic acid and Lipoxygenase. His ALOX15 research is multidisciplinary, incorporating elements of Lipid oxidation, Cancer research, Tight junction and Colitis. His study in Seleninic acid extends to Biochemistry with its themes.

His Enzyme study integrates concerns from other disciplines, such as Genome, Gene, Evolution of mammals, Catalysis and Mutagenesis. Hartmut Kühn interconnects A549 cell and Fatty acid in the investigation of issues within Arachidonic acid. Hartmut Kühn performs multidisciplinary studies into Lipoxygenase and Ketogenic diet in his work.