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Biology and Biochemistry

D-Index
50
Citations
9350
World Ranking
17608
National Ranking
502

Overview

Melissa A. Brown is affiliated with the University of Queensland in Australia. Their research primarily focuses on genetics and molecular biology, with substantial contributions in medicine.

The main fields of study in their work are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

The subfields include:

  • Genetics
  • Molecular Biology
  • Oncology
  • Cancer Research
  • Pathology and Forensic Medicine

Key research topics covered by their publications are:

  • BRCA gene mutations in cancer
  • Genomic variations and chromosomal abnormalities
  • Cancer Genomics and Diagnostics
  • Genetic factors in colorectal cancer
  • Genetic Associations and Epidemiology
  • Genomics and Rare Diseases
  • Autism Spectrum Disorder Research

Their recent publications include:

  • Integrated gene analyses of de novo variants from 46,612 trios with autism and developmental disorders (2022), Proceedings of the National Academy of Sciences
  • The impact of coding germline variants on contralateral breast cancer risk and survival (2023), The American Journal of Human Genetics
  • Biallelic variants in coenzyme Q10 biosynthesis pathway genes cause a retinitis pigmentosa phenotype (2022), npj Genomic Medicine
  • Cancer Risks Associated With TP53 Pathogenic Variants: Maximum Likelihood Analysis of Extended Pedigrees for Diagnosis of First Cancers Beyond the Li-Fraumeni Syndrome Spectrum (2024), JCO Precision Oncology
  • FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women (2023), European Journal of Human Genetics

The research has been published in venues such as:

  • Proceedings of the National Academy of Sciences
  • JCO Precision Oncology
  • The American Journal of Human Genetics
  • npj Genomic Medicine
  • European Journal of Human Genetics

Frequent co-authors include:

  • Paul A. James
  • David J. Amor
  • Lesley Andrews
  • Rosemary L. Balleine
  • Jonathan Beesley

Best Publications

  • Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

    Elgene Lim;Elgene Lim;Francois Vaillant;Di Wu;Di Wu;Natasha C Forrest

  • Deletion mapping and expression in Escherichia coli of the large genomic segment of a birnavirus.

    Ahmed A. Azad;Mittur N. Jagadish;Melissa A. Brown;Peter J. Hudson

  • Vascular endothelial cells and granulopoiesis: interleukin-1 stimulates release of G-CSF and GM-CSF

    KM Zsebo;VN Yuschenkoff;S Schiffer;D Chang

  • SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer

    Marjan E. Askarian-Amiri;Joanna Crawford;Juliet D. French;Chanel E. Smart

  • Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers

    Juliet D. French;Maya Ghoussaini;Stacey L. Edwards;Kerstin B. Meyer

  • ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer

    Damara McAndrew;Desma M. Grice;Amelia A. Peters;Felicity M. Davis

  • Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value.

    Clare Stirzaker;Elena Zotenko;Jenny Z. Song;Wenjia Qu

  • Genetic and Histopathologic Evaluation of BRCA1 and BRCA2 DNA Sequence Variants of Unknown Clinical Significance

    Georgia Chenevix-Trench;Sue Healey;Sunil Lakhani;Paul Waring

  • Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer

    Ee Ming Wong;Melissa C Southey;Stephen B Fox;Stephen B Fox;Melissa A Brown

  • Involvement of leukemia inhibitory factor and nerve growth factor in the development of dorsal root ganglion neurons

    Mark Murphy;Kate Reid;Melissa A. Brown;Perry F. Bartlett

  • Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene.

    Sue Mei Tan-Wong;Juliet D. French;Nicholas J. Proudfoot;Melissa A. Brown;Melissa A. Brown

  • Leukemia inhibitory factor (LIF) infusion stimulates skeletal muscle regeneration after injury: injured muscle expresses lif mRNA.

    W. Barnard;J. Bower;M.A. Brown;M. Murphy

  • Osteoblasts display receptors for and responses to leukemia-inhibitory factor.

    E. H. Allan;D. J. Hilton;M. A. Brown;R. S. Evely

  • A guide for functional analysis of BRCA1 variants of uncertain significance

    Gaël A. Millot;Marcelo A. Carvalho;Sandrine M. Caputo;Maaike P.G. Vreeswijk

  • Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation.

    Yaowu He;Melissa A. Brown;Joseph A. Rothnagel;Nicholas A. Saunders

  • Distinct transcription start sites generate two forms of BRCA1 mRNA

    Chun-Fang Xu;Melissa A. Brown;Julie A. Chambers;Beatrice Griffiths

  • Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

    Maya Ghoussaini;Stacey L. Edwards;Stacey L. Edwards;Kyriaki Michailidou;Silje Nord

  • BRCA1 R1699Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk

    Amanda B. Spurdle;Amanda B. Spurdle;Phillip J. Whiley;Bryony Thompson;Bryony Thompson;Bingjian Feng

  • Virus-Neutralizing and Passively Protective Monoclonal Antibodies to Infectious Bursal Disease Virus of Chickens

    K J Fahey;P McWaters;M A Brown;K Erny

  • Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions.

    Juergen Stahl;David P. Gearing;Tracy A. Willson;Melissa A. Brown

Frequent Co-Authors

Amanda B. Spurdle
Amanda B. Spurdle QIMR Berghofer Medical Research Institute
Sunil R. Lakhani
Sunil R. Lakhani University of Queensland
Georgia Chenevix-Trench
Georgia Chenevix-Trench QIMR Berghofer Medical Research Institute
Ellen Solomon
Ellen Solomon King's College London
Melissa C. Southey
Melissa C. Southey Monash University
Sean V. Tavtigian
Sean V. Tavtigian University of Utah
John L. Hopper
John L. Hopper University of Melbourne
Gregory R. Monteith
Gregory R. Monteith University of Queensland
Fergus J. Couch
Fergus J. Couch Mayo Clinic
Paolo Radice
Paolo Radice Fondazione IRCCS Istituto Nazionale dei Tumori

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