D. Lorne Tyrrell

Research.com Recognitions

• 2015 - Izaak Walton Killam Memorial Prize, Canada Council
• 2004 - Fellow of the Royal Society of Canada Academy of Science

Overview

Best Publications

• Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication.

  Wayne Vuong;Muhammad Bashir Khan;Conrad Fischer;Elena Arutyunova

  511
  Citations

• Treatment of Recurrent Genital Herpes Simplex Infections With Oral Acyclovir: A Controlled Trial

  R C Reichman;G J Badger;G J Mertz;L Corey

  391
  Citations

• Molecular Diagnosis of COVID-19: Challenges and Research Needs.

  Wei Feng;Ashley M. Newbigging;Connie Le;Bo Pang

  369
  Citations

• Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery

  Carrie S.W. Chong;Min Cao;Winnie W. Wong;Karl P. Fischer

  253
  Citations

• Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor.

  Olusegun O. Onabajo;A. Rouf Banday;Megan L. Stanifer;Wusheng Yan

  237
  Citations

• Isothermal Amplification and Ambient Visualization in a Single Tube for the Detection of SARS-CoV-2 Using Loop-Mediated Amplification and CRISPR Technology.

  Bo Pang;Jingyang Xu;Yanming Liu;Hanyong Peng

  237
  Citations

• Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial.

  Jordan J Feld;Jordan J Feld;Christopher Kandel;Mia J Biondi;Mia J Biondi;Robert A Kozak

  229
  Citations

• Structural Polypeptides of Measles Virus

  David L. J. Tyrrell;Erling Norrby

  212
  Citations

• HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus.

  Norman M. Kneteman;Anita Y. M. Howe;Tiejun Gao;Jamie Lewis

  197
  Citations

• A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans.

  John Lok Man Law;Chao Chen;Jason Wong;Darren Hockman

  197
  Citations

• IFITM1 is a tight junction protein that inhibits hepatitis C virus entry

  Courtney Wilkins;Jessica Woodward;Daryl T.-Y. Lau;Amy Barnes

  196
  Citations

• The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections.

  Adrian Egli;Deanna M Santer;Daire O’Shea;D Lorne Tyrrell

  193
  Citations

• Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses

  Mireille R. St.Vincent;Che C. Colpitts;Alexey V. Ustinov;Muhammad Muqadas

  183
  Citations

• HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice

  Michael A. Joyce;Kathie Anne Walters;Sue Ellen Lamb;Mathew M. Yeh

  180
  Citations

• Half-Life of the Duck Hepatitis B Virus Covalently Closed Circular DNA Pool In Vivo following Inhibition of Viral Replication

  William R. Addison;Kathie-Anne Walters;Winnie W. S. Wong;John S. Wilson

  158
  Citations

• Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.

  Yutaka Takebe;Carrie J. Saucedo;Garry Lund;Rie Uenishi

  142
  Citations

• Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2',3'-dideoxy-3'-thiacytidine

  Unknown

  136
  Citations

• Comprehensive in vitro characterization of PD-L1 small molecule inhibitors

  Aravindhan Ganesan;Marawan Ahmed;Isobel Okoye;Elena Arutyunova

  127
  Citations

• Anti‐HCV therapies in chimeric scid‐Alb/uPA mice parallel outcomes in human clinical application

  Norman M. Kneteman;Amy J. Weiner;John O'Connell;Marc Collett

  125
  Citations

• The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites

  Christopher J. Neufeldt;Michael A. Joyce;Nicholas Van Buuren;Aviad Levin

  124
  Citations

• Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry

  Liang Tzung Lin;Chueh Yao Chung;Wen Chan Hsu;Shun Pang Chang

  121
  Citations

• Hepatitis C virus induced up‐regulation of microRNA‐27: A novel mechanism for hepatic steatosis

  Ragunath Singaravelu;Ran Chen;Rodney K. Lyn;Daniel M. Jones

  120
  Citations

• IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza

  Adrian Egli;Deanna M. Santer;Daire O'Shea;Khaled Barakat

  110
  Citations