Chiharu Tohyama

Best Publications

• The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.

  Martin Van den Berg;Linda S. Birnbaum;Michael Denison;Mike De Vito

  4260
  Citations

• Modulation of oestrogen receptor signalling by association with the activated dioxin receptor.

  Fumiaki Ohtake;Ken-ichi Takeyama;Takahiro Matsumoto;Hirochika Kitagawa

  1149
  Citations

• Metallothionein in radiation exposure: its induction and protective role.

  Unknown

  269
  Citations

• Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds.

  Martin van den Berg;Michael S. Denison;Linda S. Birnbaum;Michael J. DeVito

  255
  Citations

• Bisphenol-A Affects Spermatogenesis in the Adult Rat Even at a Low Dose.

  Unknown

  216
  Citations

• Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

  Takashi Moriguchi;Hozumi Motohashi;Tomonori Hosoya;Osamu Nakajima

  198
  Citations

• Maternal Exposure to a Low Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Suppressed the Development of Reproductive Organs of Male Rats: Dose-Dependent Increase of mRNA Levels of 5α-Reductase Type 2 in Contrast to Decrease of Androgen Receptor in the Pubertal Ventral Prostate

  Unknown

  175
  Citations

• Cross-Talk between 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Testosterone Signal Transduction Pathways in LNCaP Prostate Cancer Cells

  N.R. Jana;S. Sarkar;M. Ishizuka;J. Yonemoto

  153
  Citations

• Reduction of metallothioneins promotes the disease expression of familial amyotrophic lateral sclerosis mice in a dose-dependent manner

  Seiichi Nagano;Masahiko Satoh;Hisae Sumi;Harutoshi Fujimura

  143
  Citations

• Developmental neurotoxicity of dioxin and its related compounds.

  Unknown

  108
  Citations

• Aryl hydrocarbon receptor-mediated effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on glucose-stimulated insulin secretion in mice.

  Hisaka Kurita;Wataru Yoshioka;Noriko Nishimura;Naoto Kubota

  101
  Citations

• Effects of vinclozolin administration on sperm production and testosterone biosynthetic pathway in adult male rat.

  Unknown

  99
  Citations

• Enhanced Renal Toxicity by Inorganic Mercury in Metallothionein-Null Mice

  Unknown

  99
  Citations

• A constitutively active arylhydrocarbon receptor induces growth inhibition of jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest.

  Tomohiro Ito;Shin Ichi Tsukumo;Norio Suzuki;Hozumi Motohashi

  97
  Citations

• Stabilization of mutant Cu/Zn superoxide dismutase (SOD1) protein by coexpressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice.

  Kei Fukada;Seiichi Nagano;Masahiko Satoh;Chiharu Tohyama

  91
  Citations

• Altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in aryl hydrocarbon receptor-null mice.

  Unknown

  89
  Citations

• Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: a possible estrogenic effect of di(n-butyl) phthalate

  Unknown

  87
  Citations

• Executive function deficits and social-behavioral abnormality in mice exposed to a low dose of dioxin in utero and via lactation.

  Toshihiro Endo;Masaki Kakeyama;Yukari Uemura;Asahi Haijima

  87
  Citations

• Molecular targets that link dioxin exposure to toxicity phenotypes

  Wataru Yoshioka;Richard E. Peterson;Chiharu Tohyama

  86
  Citations

• In utero and Lactational Exposure to Acetamiprid Induces Abnormalities in Socio-Sexual and Anxiety-Related Behaviors of Male Mice

  Kazuhiro Sano;Tomohiko Isobe;Jiaxin Yang;Tin-Tin Win-Shwe

  82
  Citations