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Biology and Biochemistry

D-Index
63
Citations
29347
World Ranking
9964
National Ranking
4363

Overview

Frank A. Middleton is affiliated with SUNY Upstate Medical University in the United States. Their research spans multiple fields with a primary focus on Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Middleton's work engages deeply with subfields such as Infectious Diseases, Molecular Biology, Neurology, Biological Psychiatry, and Epidemiology.

The main topics covered in their research include:

  • Tryptophan and brain disorders
  • SARS-CoV-2 detection and testing
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Mitochondrial Function and Pathology
  • Stress Responses and Cortisol
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies

Middleton has contributed to various recent papers addressing diverse biomedical and public health issues. Some key publications include:

  • Co-quantification of crAssphage increases confidence in wastewater-based epidemiology for SARS-CoV-2 in low prevalence areas (2021), published in Water Research X
  • Quantification of SARS-CoV-2 and cross-assembly phage (crAssphage) from wastewater to monitor coronavirus transmission within communities (2020), in bioRxiv (Cold Spring Harbor Laboratory)
  • Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation (2024), Nature Communications
  • Diagnosing mild traumatic brain injury using saliva RNA compared to cognitive and balance testing (2020), Clinical and Translational Medicine
  • Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis (2023), Nature Metabolism

Their frequent co-authors include:

  • Maree J. Webster
  • Cynthia Shannon Weickert
  • Yunting Zhu
  • Paul T. Massa
  • David A. Larsen

Middleton regularly publishes in notable venues, with the most frequent being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Brain Behavior and Immunity
  • Nature Metabolism
  • The International Journal of Neuropsychopharmacology
  • Water Research X

Best Publications

  • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

    Shaun M. Purcell;Shaun M. Purcell;Naomi R. Wray;Jennifer L. Stone;Jennifer L. Stone;Peter M. Visscher

  • Basal ganglia and cerebellar loops: motor and cognitive circuits.

    Frank A Middleton;Peter L Strick;Peter L Strick

  • Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function

    Frank A. Middleton;Peter L. Strick

  • Rare chromosomal deletions and duplications increase risk of schizophrenia

    Jennifer L. Stone;Jennifer L. Stone;Jennifer L. Stone;Michael C. O’Donovan;Hugh Gurling;George K. Kirov

  • Cerebellar Projections to the Prefrontal Cortex of the Primate

    Frank A. Middleton;Peter L. Strick;Peter L. Strick

  • Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex.

    Károly Mirnics;Frank A. Middleton;Adriana Marquez;David A. Lewis

  • PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease

    Bin Zheng;Zhixiang Liao;Joseph J. Locascio;Kristen A. Lesniak

  • Basal Ganglia Output and Cognition: Evidence from Anatomical, Behavioral, and Clinical Studies

    Frank A. Middleton;Peter L. Strick

  • Environmental risk factors for attention-deficit hyperactivity disorder

    Tania Das Banerjee;Frank Middleton;Stephen V. Faraone

  • Meta-Analysis of Genome-Wide Association Studies of Attention- Deficit/Hyperactivity Disorder

    Benjamin M. Neale;Benjamin M. Neale;Sarah E. Medland;Sarah E. Medland;Stephan Ripke;Stephan Ripke;Philip Asherson

  • Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia.

    K. Mirnics;F. A. Middleton;G. D. Stanwood;D. A. Lewis

  • Basal-ganglia ‘Projections’ to the Prefrontal Cortex of the Primate

    Frank A. Middleton;Peter L. Strick

  • Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse

    Károly Mirnics;Frank A. Middleton;David A. Lewis;Pat Levitt

  • Gene Expression Profiling Reveals Alterations of Specific Metabolic Pathways in Schizophrenia

    Frank A. Middleton;Karoly Mirnics;Joseph N. Pierri;David A. Lewis

  • Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication.

    J Fuchs;Christer Nilsson;J Kachergus;M Munz

  • Association and linkage analyses of RGS4 polymorphisms in schizophrenia

    Kodavali V. Chowdari;Karoly Mirnics;Prachi Semwal;Joel Wood

  • Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder

    Josephine Elia;Joseph T. Glessner;Kai Wang;Nagahide Takahashi

  • The temporal lobe is a target of output from the basal ganglia

    Frank A. Middleton;Peter L. Strick

  • Genomic investigation of alpha-synuclein multiplication and parkinsonism

    Owen A. Ross;Adam T. Braithwaite;Lisa M. Skipper;Jennifer Kachergus

  • Cerebellar output channels.

    Frank A. Middleton;Peter L. Strick

Frequent Co-Authors

Hans-Christoph Steinhausen
Hans-Christoph Steinhausen University of Southern Denmark
Benjamin M. Neale
Benjamin M. Neale Harvard University
Peter L. Strick
Peter L. Strick University of Pittsburgh
Pat Levitt
Pat Levitt University of Southern California
Mark J. Daly
Mark J. Daly Massachusetts General Hospital
Kevin M. Antshel
Kevin M. Antshel Syracuse University
Susanne Walitza
Susanne Walitza University of Zurich
Wendy R. Kates
Wendy R. Kates SUNY Upstate Medical University
Eric Mick
Eric Mick University of Massachusetts Chan Medical School
David A. Lewis
David A. Lewis University of Pittsburgh

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