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Molecular Biology

D-Index
59
Citations
18985
World Ranking
1998
National Ranking
995

Overview

Irit Lax is affiliated with Yale University in the United States and conducts research primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work encompasses several subfields including Molecular Biology, Neurology, Genetics, Immunology, and Radiology, Nuclear Medicine and Imaging.

The main topics they focus on include:

  • Neuroblastoma Research and Treatments
  • Fibroblast Growth Factor Research
  • Genetic Syndromes and Imprinting
  • Mast cells and histamine
  • Monoclonal and Polyclonal Antibodies Research
  • Chronic Myeloid Leukemia Treatments
  • Cancer therapeutics and mechanisms

Several recent papers authored or coauthored by Irit Lax include:

  • "Mechanism for the activation of the anaplastic lymphoma kinase receptor," 2021, published in Nature
  • "Structural basis for ligand reception by anaplastic lymphoma kinase," 2021, published in Nature
  • "FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho," 2020, published in Proceedings of the National Academy of Sciences
  • "Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention," 2023, published in Proceedings of the National Academy of Sciences
  • "Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability," 2023, published in Proceedings of the National Academy of Sciences

Irit Lax frequently collaborates with the following coauthors:

  • Joseph Schlessinger
  • Jyotidarsini Mohanty
  • Yoshihisa Suzuki
  • S.G. Krimmer
  • Sangwon Lee

Their publications have appeared predominantly in the following venues:

  • Proceedings of the National Academy of Sciences
  • Nature
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Cellular signaling by fibroblast growth factor receptors.

    V.P. Eswarakumar;I. Lax;J. Schlessinger

  • Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

    Towia A. Libermann;Harris R. Nusbaum;Nissim Razon;Richard Kris

  • A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

    H Kouhara;Y.R Hadari;T Spivak-Kroizman;J Schilling

  • Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation.

    T. Spivak-Kroizman;M.A. Lemmon;I. Dikic;J.E. Ladbury

  • Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?

    Joseph Schlessinger;Irit Lax;Mark Lemmon

  • Structure of a heparin-linked biologically active dimer of fibroblast growth factor.

    Anna D. DiGabriele;Irit Lax;Denise I. Chen;Carl M. Svahn

  • Two EGF molecules contribute additively to stabilization of the EGFR dimer

    Mark A. Lemmon;Zimei Bu;John Edward Simon Durham Ladbury;Min Zhou;Min Zhou

  • FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.

    S. H. Ong;G. R. Guy;Y. R. Hadari;S. Laks

  • Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation

    Y. R. Hadari;H. Kouhara;I. Lax;J. Schlessinger

  • Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies.

    A B Schreiber;T A Libermann;I Lax;Y Yarden

  • Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.

    S. H. Ong;Y. R. Hadari;N. Gotoh;G. R. Guy

  • Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor

    Satoru Yuzawa;Yarden Opatowsky;Zhongtao Zhang;Valsan Mandiyan

  • Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways

    Y. R. Hadari;N. Gotoh;H. Kouhara;I. Lax

  • Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein

    R.M. Kris;I. Lax;W. Gullick;M.D. Waterfield

  • PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

    Ivan Dikic;Joseph Schlessinger;Irit Lax

  • Regulation of cell proliferation by epidermal growth factor.

    Joseph Schlessinger;Alain B. Schreiber;Andrea Levi;Irit Lax

  • All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.

    B L Margolis;I Lax;R Kris;M Dombalagian

  • Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.

    I Lax;F Bellot;R Howk;A Ullrich

  • Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

    Erin D Lew;Jennifer Oh;Patrick G Burrola;Irit Lax

  • The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway

    Dawn R Mattoon;Dawn R Mattoon;Betty Lamothe;Betty Lamothe;Irit Lax;Joseph Schlessinger

Frequent Co-Authors

Joseph Schlessinger
Joseph Schlessinger Yale University
Towia A. Libermann
Towia A. Libermann Beth Israel Deaconess Medical Center
Yosef Yarden
Yosef Yarden Weizmann Institute of Science
Mark A. Lemmon
Mark A. Lemmon Yale University
Axel Ullrich
Axel Ullrich Max Planck Institute of Biochemistry
David Givol
David Givol Weizmann Institute of Science
John E. Ladbury
John E. Ladbury University of Leeds
Sachdev S. Sidhu
Sachdev S. Sidhu University of Waterloo
Wayne A. Hendrickson
Wayne A. Hendrickson Columbia University
Titus J. Boggon
Titus J. Boggon Yale University

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