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Molecular Biology

D-Index
42
Citations
7374
World Ranking
3022
National Ranking
1434

Overview

James J. Manfredi is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their primary fields of study include Biochemistry, Genetics and Molecular Biology, with a total of 26 publications, and Medicine, covering 15 publications.

Their research extensively spans subfields such as Molecular Biology (21 publications), Oncology (10 publications), Pulmonary and Respiratory Medicine (4 publications), Biotechnology (3 publications), and Cancer Research (2 publications). Key topics of focus in their work include Cancer-related Molecular Pathways, Epigenetics and DNA Methylation, RNA modifications and cancer, Ferroptosis and cancer prognosis, Cancer Research and Treatments, Molecular Biology Techniques and Applications, and Protein Degradation and Inhibitors.

Among their recent papers are the following:

  • The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute, 2022, Cell Death and Differentiation
  • Specific regulation of BACH1 by the hotspot mutant p53R175H reveals a distinct gain-of-function mechanism, 2023, Nature Cancer
  • p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression, 2023, Cancer Discovery
  • Mdm2 and MdmX: Partners in p53 Destruction, 2021, Cancer Research
  • Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates, 2021, Nature Communications

Frequent co-authors in their research collaborations include Lois Resnick-Silverman, Anil K. Rustgi, Carol Prives, Gizem Efe, and Katherine Cunningham.

Their work has appeared most often in the journal Cancer Research, with six publications, followed by one publication each in Cell Death and Differentiation, Nature Cancer, Cancer Discovery, and Nature Communications.

James J. Manfredi has also contributed to book literature, having published a title under Springer Science+Business Media titled Cell Cycle Checkpoints in 2021.

Best Publications

  • Multiple roles of the tumor suppressor p53.

    Jill Bargonetti;James J Manfredi

  • The Mdm2–p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

    James J. Manfredi

  • The p53 tumor suppressor participates in multiple cell cycle checkpoints.

    Luciana E. Giono;James J. Manfredi

  • A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

    Jill Bargonetti;James J. Manfredi;Xinbin Chen;Daniel R. Marshak

  • p53/HMGB1 complexes regulate autophagy and apoptosis.

    Kristen M. Livesey;Rui Kang;Philip Vernon;William Buchser

  • DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.

    Selvon St. Clair;Luciana Giono;Shohreh Varmeh-Ziaie;Lois Resnick-Silverman

  • Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors

    Peng Li;Xi He;M. R. Gerrero;M. Mok

  • Another fork in the road--life or death decisions by the tumour suppressor p53.

    Luis A Carvajal;James J Manfredi

  • Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein Association

    Sachchidanand;Lois Resnick-Silverman;Sherry Yan;Shiraz Mutjaba

  • A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes.

    Edward C Thornborrow;Sejal Patel;Anthony E Mastropietro;Elissa M Schwartzfarb

  • The p53 tumor suppressor protein: meeting review.

    Carol Prives;James J. Manfredi

  • The transforming activity of simian virus 40 large tumor antigen.

    James J. Manfredi;Carol Prives

  • Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53.

    Lois Resnick-Silverman;Selvon St. Clair;Matthew Maurer;Kathy Zhao

  • Evidence against a Role for SV40 in Human Mesothelioma

    James J. Manfredi;Jianli Dong;Wen Jun Liu;Lois Resnick-Silverman

  • E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

    Luis A. Carvajal;Pierre-Jacques Hamard;Crystal Tonnessen;James J. Manfredi

  • The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain

    Oleg Laptenko;Idit Shiff;Will Freed-Pastor;Andrew Zupnick

  • The Tumor Suppressor Protein p53 Requires a Cofactor to Activate Transcriptionally the Human BAX Promoter

    Edward C. Thornborrow;James J. Manfredi

  • p53 and Cell Cycle Effects After DNA Damage

    Emir Senturk;James J. Manfredi

  • p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

    E K Benson;S K Mungamuri;O Attie;M Kracikova

  • p53-Independent Effects of Mdm2

    Stephen Bohlman;James J. Manfredi

Frequent Co-Authors

Stuart A. Aaronson
Stuart A. Aaronson Icahn School of Medicine at Mount Sinai
Carol Prives
Carol Prives Columbia University
Wei Gu
Wei Gu Columbia University
Michael T. Lotze
Michael T. Lotze University of Pittsburgh
Tarik Möröy
Tarik Möröy University of Montreal
Steven B. McMahon
Steven B. McMahon Thomas Jefferson University
Ming-Ming Zhou
Ming-Ming Zhou Icahn School of Medicine at Mount Sinai
Sam W. Lee
Sam W. Lee Broad Institute
Lei Zeng
Lei Zeng Icahn School of Medicine at Mount Sinai
James R. Broach
James R. Broach Pennsylvania State University

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