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Chemistry

D-Index
86
Citations
25975
World Ranking
2545
National Ranking
890

Research.com Recognitions

  • 2008 - Linus Pauling Award, American Chemical Society (ACS)
  • 2005 - NAS Award in Chemical Sciences, National Academy of Sciences (US) For his leading role in the development of bioorganic chemistry, and especially for deep and lasting contributions to the understanding of enzyme mechanisms.
  • 1979 - Fellow of John Simon Guggenheim Memorial Foundation
  • 1978 - Tolman Award, American Chemical Society (ACS)
  • 1974 - Member of the National Academy of Sciences

Overview

Thomas C. Bruice is affiliated with the University of California, Santa Barbara in the United States. Their academic career is associated with research and scholarship in chemistry, particularly focusing on the field of bioorganic chemistry and enzyme mechanisms.

Throughout their career, Bruice has received multiple notable awards. In 2008, they were honored with the Linus Pauling Award from the American Chemical Society (ACS). In 2005, Bruice received the NAS Award in Chemical Sciences from the National Academy of Sciences (US) for a leading role in the development of bioorganic chemistry, especially for significant contributions to understanding enzyme mechanisms.

Earlier recognitions include being named a Fellow of the John Simon Guggenheim Memorial Foundation in 1979 and receiving the Tolman Award from the American Chemical Society (ACS) in 1978. They became a member of the National Academy of Sciences in 1974.

Bruice's research contributions primarily explore how enzymes catalyze biochemical reactions at a molecular level, advancing the understanding of enzyme function within bioorganic chemistry. This focus highlights a deep engagement with the mechanisms that govern biological catalysis.

Best Publications

  • Chemical basis for enzyme catalysis.

    Thomas C. Bruice;Stephen J. Benkovic

  • A View at the Millennium: the Efficiency of Enzymatic Catalysis

    Thomas C. Bruice

  • Mechanism of alkene epoxidation by iron, chromium, and manganese higher valent oxo-metalloporphyrins

    Drazen Ostovic;Thomas C. Bruice

  • Mechanisms of flavin catalysis

    Thomas C. Bruice

  • Ground State and Transition State Contributions to the Rates of Intramolecular and Enzymatic Reactions

    Thomas C. Bruice;Felice C. Lightstone

  • The Effect of Geminal Substitution Ring Size and Rotamer Distribution on the Intramolecular Nucleophilic Catalysis of the Hydrolysis of Monophenyl Esters of Dibasic Acids and the Solvolysis of the Intermediate Anhydrides

    Thomas C. Bruice;Upendra K. Pandit

  • Ground State Conformations and Entropic and Enthalpic Factors in the Efficiency of Intramolecular and Enzymatic Reactions. 1. Cyclic Anhydride Formation by Substituted Glutarates, Succinate, and 3,6-Endoxo-Δ4-tetrahydrophthalate Monophenyl Esters

    Felice C. Lightstone;Thomas C. Bruice

  • Reactions of hydroperoxides with metallotetraphenylporphyrins in aqueous solutions

    Thomas C. Bruice

  • Mechanism of manganese porphyrin-catalyzed oxidation of alkenes. Role of manganese(IV)-oxo species

    Ramesh D. Arasasingham;Gong Xin He;Thomas C. Bruice

  • The near attack conformation approach to the study of the chorismate to prephenate reaction.

    Sun Hur;Thomas C Bruice

  • Imidazole Catalysis. II. The Reaction of Substituted Imidazoles with Phenyl Acetates in Aqueous Solution

    Thomas C. Bruice;Gaston L. Schmir

  • Synthesis of a thymidyl pentamer of deoxyribonucleic guanidine and binding studies with DNA homopolynucleotides.

    R O Dempcy;K A Browne;T C Bruice

  • Imidazole Catalysis. I. The Catalysis of the Hydrolysis of Phenyl Acetates by Imidazole

    Thomas C. Bruice;Gaston L. Schmir

  • Recent advances in atomic force microscopy of DNA.

    Helen G. Hansma;Robert L. Sinsheimer;Jay Groppe;Thomas C. Bruice

  • RECENT STUDIES OF NUCLEOPHILIC, GENERAL-ACID, AND METAL ION CATALYSIS OF PHOSPHATE DIESTER HYDROLYSIS

    Andrei Blaskó;Thomas C. Bruice

  • Influence of hydrogen ion activity and general acid-base catalysis on the rate of decomposition of hydrogen peroxide by a novel nonaggregating water-soluble iron(III) tetraphenylporphyrin derivative

    Matthias F. Zipplies;William A. Lee;Thomas C. Bruice

  • Characterization of the Short Strong Hydrogen Bond in Benzoylacetone by ab Initio Calculations and Accurate Diffraction Experiments. Implications for the Electronic Nature of Low-Barrier Hydrogen Bonds in Enzymatic Reactions

    Birgit Schiøtt;Bo Brummerstedt Iversen;Georg Kent Hellerup Madsen;Thomas C. Bruice

  • Simple synthesis of a 4a-hydroperoxy adduct of a 1,5-dihydroflavine: preliminary studies of a model for bacterial luciferase.

    Cemal Kemal;Thomas C. Bruice

  • Computational approaches: reaction trajectories, structures, and atomic motions. Enzyme reactions and proficiency.

    Thomas C. Bruice

  • Intermediates in the epoxidation of alkenes by cytochrome P-450 models. 5. Epoxidation of alkenes catalyzed by a sterically hindered (meso-tetrakis(2,6-dibromophenyl)porphinato)iron(III) chloride

    Drazen Ostovic;Thomas C. Bruice

Frequent Co-Authors

Rafik Karaman
Rafik Karaman Al-Quds University
Donald M. Jerina
Donald M. Jerina National Institutes of Health
Haruhiko Yagi
Haruhiko Yagi National Institutes of Health
Stephen J. Benkovic
Stephen J. Benkovic Pennsylvania State University
Ben M. Dunn
Ben M. Dunn University of Florida
Seiji Shinkai
Seiji Shinkai Kyushu University
Birgit Schiøtt
Birgit Schiøtt Aarhus University
Dale E. Edmondson
Dale E. Edmondson Emory University
Changhee Lee
Changhee Lee Seoul National University
Bo B. Iversen
Bo B. Iversen Aarhus University

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