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Biology and Biochemistry

D-Index
50
Citations
7496
World Ranking
17754
National Ranking
1228

Overview

Christian P. Sommerhoff is affiliated with Ludwig-Maximilians-Universität München in Germany. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with significant focus on subfields including Immunology, Physiology, Immunology and Allergy, Rheumatology, and Oncology.

The research topics covered in their work include:

  • Mast cells and histamine
  • Asthma and respiratory diseases
  • Food Allergy and Anaphylaxis Research
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Protease and Inhibitor Mechanisms
  • Osteoarthritis Treatment and Mechanisms
  • Chemokine receptors and signaling

Among recent publications authored or coauthored by Sommerhoff are:

  • "Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis," 2023, Nature Communications
  • "Mast cell chymase regulates extracellular matrix remodeling-related events in primary human small airway epithelial cells," 2022, Journal of Allergy and Clinical Immunology
  • "Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma," 2021, Journal of Allergy and Clinical Immunology
  • "Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA," 2020, International Journal of Molecular Sciences
  • "Mast Cell Tryptase Potentiates Neutrophil Extracellular Trap Formation," 2021, Journal of Innate Immunity

Frequent co-authors in their research include:

  • Gunnar Pejler
  • Xinran Zhao
  • Aida Paivandy
  • Fábio Rabelo Melo
  • Maria Lampinen

Christian P. Sommerhoff's work has been published in various venues, with repeated contributions in:

  • Journal of Allergy and Clinical Immunology
  • International Journal of Molecular Sciences
  • Nature Communications
  • Journal of Innate Immunity
  • ChemMedChem

Best Publications

  • Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells.

    C P Sommerhoff;J A Nadel;C B Basbaum;G H Caughey

  • Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.

    Pedro José Barbosa Pereira;Andreas Bergner;Sandra Macedo-Ribeiro;Robert Huber

  • Tetrahydrobiopterin as an Alternative Treatment for Mild Phenylketonuria

    Ania C Muntau;Wulf Röschinger;Matthias Habich;Hans Demmelmair

  • LEKTI, a novel 15-domain type of human serine proteinase inhibitor.

    Hans-Jürgen Mägert;Ludger Ständker;Peter Kreutzmann;Hans-Dieter Zucht

  • Therapeutic Promise of Proteinase-Activated Receptor-2 Antagonism in Joint Inflammation

    Elizabeth B. Kelso;John C. Lockhart;Todd Hembrough;Lynette Dunning

  • Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2.

    Peter H. Killian;Emanuel Kronski;Katharina M. Michalik;Ottavia Barbieri;Ottavia Barbieri

  • miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2

    Emanuel Kronski;Micol E. Fiori;Ottavia Barbieri;Ottavia Barbieri;Simonetta Astigiano

  • Mast cell chymase. A potent secretagogue for airway gland serous cells.

    C P Sommerhoff;G H Caughey;W E Finkbeiner;S C Lazarus

  • Aortic dissection: sensitivity and specificity of MR imaging.

    B A Kersting-Sommerhoff;C B Higgins;R D White;C P Sommerhoff

  • A Kazal-type inhibitor of human mast cell tryptase: isolation from the medical leech Hirudo medicinalis, characterization, and sequence analysis.

    Christian P. Sommerhoff;Christa Söllner;Reinhardt Mentele;Gerd P. Piechottka

  • Agonists of Proteinase-Activated Receptor 2 Induce Cytokine Release and Activation of Nuclear Transcription Factor κB in Human Dermal Microvascular Endothelial Cells

    Victoria M Shpacovitch;Thomas Brzoska;Jörg Buddenkotte;Christoph Stroh

  • Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers

    Stefanie Gilles;Stefan Zahler;Ulrich Welsch;Christian P Sommerhoff

  • Sevoflurane preserves the endothelial glycocalyx against ischaemia–reperfusion injury

    T. Annecke;D. Chappell;C. Chen;M. Jacob

  • High-affinity Cyclic Peptide Matriptase Inhibitors

    Pedro Quimbar;Uru Malik;Christian P. Sommerhoff;Quentin Kaas

  • Loss of Function in Phenylketonuria Is Caused by Impaired Molecular Motions and Conformational Instability

    Søren W. Gersting;Kristina F. Kemter;Michael Staudigl;Dunja D. Messing

  • A carboxypeptidase inhibitor from the medical leech Hirudo medicinalis. Isolation, sequence analysis, cDNA cloning, recombinant expression, and characterization.

    David Reverter;Josep Vendrell;Francesc Canals;Jeanny Horstmann

  • Matrix metalloproteinases (MMPs) in breast cancer cell lines of different tumorigenicity.

    Beatrice E Bachmeier;Andreas G Nerlich;Ralf Lichtinghagen;Christian P Sommerhoff

  • The Three-dimensional Structure of Recombinant Leech-derived Tryptase Inhibitor in Complex with Trypsin: IMPLICATIONS FOR THE STRUCTURE OF HUMAN MAST CELL TRYPTASE AND ITS INHIBITION *

    Milton T. Stubbs;Milton T. Stubbs;Robert Morenweiser;Jörg Stürzebecher;Margit Bauer

  • Isolation and characterization of hirustasin, an antistasin-type serine-proteinase inhibitor from the medical leech Hirudo medicinalis

    Christa Söllner;Reinhardt Mentele;Christoph Eckerskorn;Hans Fritz

  • Shedding of the coronary endothelial glycocalyx: effects of hypoxia/reoxygenation vs ischaemia/reperfusion

    T. Annecke;J. Fischer;H. Hartmann;J. Tschoep

Frequent Co-Authors

Hans Fritz
Hans Fritz Ludwig-Maximilians-Universität München
Viktor Magdolen
Viktor Magdolen Technical University of Munich
Francesc X. Avilés
Francesc X. Avilés Autonomous University of Barcelona
Manfred Schmitt
Manfred Schmitt Technical University of Munich
Wolfram Bode
Wolfram Bode Max Planck Society
Harald Kolmar
Harald Kolmar Technical University of Darmstadt
Gunnar Pejler
Gunnar Pejler Uppsala University
Jay A. Nadel
Jay A. Nadel University of California, San Francisco
George H. Caughey
George H. Caughey University of California, San Francisco
Walter E. Finkbeiner
Walter E. Finkbeiner University of California, San Francisco

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