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Lars Hellman

Lars Hellman

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
8465
World Ranking
15813
National Ranking
241

Overview

Lars Hellman is affiliated with Uppsala University in Sweden. Their research primarily focuses on immunology and microbiology, with particular attention to immunology as a subfield. The scope of their work covers various related areas including molecular biology, immunology and allergy, genetics, and physiology.

The scientist's main topics of study include:

  • Mast cells and histamine
  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Asthma and respiratory diseases
  • Polyamine Metabolism and Applications
  • Food Allergy and Anaphylaxis Research

Lars Hellman has authored numerous papers, including the following recent selected publications:

  • "Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins," 2021, published in Biological Chemistry
  • "Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity," 2020, published in Cells
  • "Mast Cell and Basophil Granule Proteases - In Vivo Targets and Function," 2022, published in Frontiers in Immunology
  • "Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgfβ Signaling in the Tumor Microenvironment," 2022, published in Cancers
  • "Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3," 2020, published in International Journal of Molecular Sciences

Frequent co-authors in their research include:

  • Srinivas Akula
  • Zhirong Fu
  • Sara Wernersson
  • Anna-Karin Olsson
  • Michael Thorpe

Lars Hellman has published frequently in several scientific journals. The most common publication venues are:

  • International Journal of Molecular Sciences
  • Preprints.org
  • Developmental & Comparative Immunology
  • Frontiers in Immunology
  • Cells

Their work spans a combination of applied and fundamental research in fields linked to immune cell biology, protease function, and inflammatory mechanisms. This includes detailed studies on mast cells, basophils, and enzyme interactions relevant to immune responses and disease pathology.

Best Publications

  • Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme

    Erik Forsberg;Gunnar Pejler;Maria Ringvall;Carolina Lunderius

  • Mice lacking histidine decarboxylase exhibit abnormal mast cells

    Hiroshi Ohtsu;Satoshi Tanaka;Tadashi Terui;Yoshio Hori

  • Phenotypic Characterization of the Human Mast-Cell Line HMC-1

    G. Nilsson;T. Blom;M. Kusche‐Gullberg;L. Kjellen

  • Secretory Granule Proteases in Rat Mast Cells. Cloning of 10 Different Serine Proteases and a Carboxypeptidase A from Various Rat Mast Cell Populations

    Claudia Lützelschwab;Gunnar Pejler;Maria Aveskogh;Lars Hellman

  • KRAB Zinc Finger Proteins: An Analysis of the Molecular Mechanisms Governing Their Increase in Numbers and Complexity During Evolution

    Camilla Looman;Magnus Åbrink;Charlotta Mark;Lars Hellman

  • The Extended Cleavage Specificity of Human Thrombin

    Maike Gallwitz;Mattias Enoksson;Michael Thorpe;Lars Hellman

  • Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation *

    Ananya Roy;Goutham Ganesh;Helena Sippola;Sara Bolin

  • Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases.

    Ranyang Huang;Thomas Blom;Lars Hellman

  • Fc Receptors for Immunoglobulins and Their Appearance during Vertebrate Evolution

    Srinivas Akula;Sayran Mohammadamin;Lars Hellman

  • Conserved interaction between distinct Krüppel-associated box domains and the transcriptional intermediary factor 1 beta.

    Magnus Abrink;José A. Ortiz;Charlotta Mark;Cecilia Sanchez

  • Human cell lines U-937, THP-1 and Mono Mac 6 represent relatively immature cells of the monocyte-macrophage cell lineage.

    M. Abrink;A. E. Gobl;Ranyang Huang;K. Nilsson

  • Lyn Kinase Controls Basophil GATA-3 Transcription Factor Expression and Induction of Th2 Cell Differentiation

    Nicolas Charles;Wendy T. Watford;Haydeé L. Ramos;Lars Hellman

  • Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells.

    Tiago Braga;Mirjana Grujic;Agneta Lukinius;Lars Hellman

  • Loss of Histochemical Identity in Mast Cells Lacking Carboxypeptidase A

    Thorsten B. Feyerabend;Heinz Hausser;Annette Tietz;Carmen Blum

  • MMCP-8, the first lineage-specific differentiation marker for mouse basophils. Elevated numbers of potent IL-4-producing and MMCP-8-positive cells in spleens of malaria-infected mice.

    Maryam Poorafshar;Helena Helmby;Marita Troye-Blomberg;Lars Hellman

  • Expression of lactoferrin in the kidney: Implications for innate immunity and iron metabolism

    Magnus Åbrink;Eric Larsson;Anders Gobl;Lars Hellman

  • The extended cleavage specificity of the rodent β-chymases rMCP-1 and mMCP-4 reveal major functional similarities to the human mast cell chymase

    Mattias K. Andersson;Ulrika Karlson;Lars Hellman

  • Evidence for an early appearance of modern post-switch isotypes in mammalian evolution; cloning of IgE, IgG and IgA from the marsupial Monodelphis domestica.

    Maria Aveskogh;Lars Hellman

  • The NF-kappa B-binding site mediates phorbol ester-inducible transcription in nonlymphoid cells.

    B. Nelsen;L. Hellman;Ranjan Sen

  • Conserved Interaction Between Distinct Krüppel-associated box Domains and the Transcriptional Intermediary factor 1β

    Magnus Åbrink;José A. Ortiz;Charlotta Mark;Cecilia Sanchez

Frequent Co-Authors

Magnus Åbrink
Magnus Åbrink Swedish University of Agricultural Sciences
Gunnar Pejler
Gunnar Pejler Uppsala University
Ulf Pettersson
Ulf Pettersson Uppsala University
Katherine Belov
Katherine Belov University of Sydney
Gunnar Nilsson
Gunnar Nilsson Karolinska Institute
Lena Kjellén
Lena Kjellén Uppsala University
Kenneth Nilsson
Kenneth Nilsson Uppsala University
Claus Bachert
Claus Bachert Karolinska Institute
Lennart Hammarström
Lennart Hammarström Karolinska Institute
Ulrich Blank
Ulrich Blank Université Paris Cité

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