World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
13330
World Ranking
16507
National Ranking
6834

Research.com Recognitions

  • 2019 - Fellow of the American Academy of Arts and Sciences

Overview

Jeff Gelles is affiliated with Brandeis University in the United States and has an extensive research record in the fields of Biochemistry, Genetics, and Molecular Biology. Their work predominantly covers Molecular Biology, with significant contributions also made to Biophysics, Cell Biology, Genetics, and Ecology.

The main research topics that Jeff Gelles has focused on include DNA Repair Mechanisms, RNA and protein synthesis mechanisms, Genomics and Chromatin Dynamics, RNA Research and Splicing, Advanced Fluorescence Microscopy Techniques, Bacterial Genetics and Biotechnology, and Bacteriophages and microbial interactions.

Among the recent papers authored or co-authored by Jeff Gelles are:

  • Single-molecule studies reveal branched pathways for activator-dependent assembly of RNA polymerase II pre-initiation complexes, 2021, Molecular Cell
  • Dynamics of RNA polymerase II and elongation factor Spt4/5 recruitment during activator-dependent transcription, 2020, Proceedings of the National Academy of Sciences
  • Alternative transcription cycle for bacterial RNA polymerase, 2020, Nature Communications
  • Twinfilin bypasses assembly conditions and actin filament aging to drive barbed end depolymerization, 2020, The Journal of Cell Biology
  • DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7, 2021, eLife

Jeff Gelles has collaborated frequently with several researchers, notably Larry J. Friedman, Stephen P. Bell, Koe Inlow, Stephen Buratowski, and Jané Kondev. These collaborations reflect notable partnerships in studies centered around transcriptional mechanisms and molecular processes.

The scientist's publications have appeared most frequently in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • Proceedings of the National Academy of Sciences
  • Molecular Cell
  • Nature Communications

Among professional recognitions, Jeff Gelles was named a Fellow of the American Academy of Arts and Sciences in 2019.

Best Publications

  • Stretching DNA with optical tweezers

    M.D. Wang;H. Yin;R. Landick;J. Gelles

  • Force and Velocity Measured for Single Molecules of RNA Polymerase

    Michelle D. Wang;Mark J. Schnitzer;Hong Yin;Robert Landick

  • Tracking kinesin-driven movements with nanometre-scale precision

    Jeff Gelles;Bruce J. Schnapp;Michael P. Sheetz

  • Transcription against an applied force

    Hong Yin;Michelle D. Wang;Karel Svoboda;Robert Landick

  • Coupling of kinesin steps to ATP hydrolysis

    Wei Hua;Edgar C. Young;Margaret L. Fleming;Jeff Gelles

  • Ubiquitous transcriptional pausing is independent of RNA polymerase backtracking.

    Keir C. Neuman;Elio A. Abbondanzieri;Robert Landick;Jeff Gelles

  • Transcription by single molecules of RNA polymerase observed by light microscopy.

    Dorothy A. Schafer;Jeff Gelles;Michael P. Sheetz;Robert Landick

  • Ordered and Dynamic Assembly of Single Spliceosomes

    Aaron A. Hoskins;Larry J. Friedman;Sarah S. Gallagher;Daniel J. Crawford;Daniel J. Crawford

  • Imaging of single-molecule translocation through nuclear pore complexes

    Weidong Yang;Jeff Gelles;Siegfried M. Musser

  • Measurement of lactose repressor-mediated loop formation and breakdown in single DNA molecules

    Laura Finzi;Jeff Gelles

  • Distinguishing Inchworm and Hand-Over-Hand Processive Kinesin Movement by Neck Rotation Measurements

    Wei Hua;Johnson Chung;Jeff Gelles

  • RNA Polymerase as a Molecular Motor

    Jeff Gelles;Robert Landick

  • Failure of a single-headed kinesin to track parallel to microtubule protofilaments.

    Elise Berliner;Edgar C. Young;Karin Anderson;Hansraj K. Mahtani

  • Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

    Simina Ticau;Larry J. Friedman;Nikola A. Ivica;Jeff Gelles

  • Tethered particle motion method for studying transcript elongation by a single RNA polymerase molecule

    Hong Yin;R. Landick;J. Gelles

  • Rocket launcher mechanism of collaborative actin assembly defined by single-molecule imaging

    Dennis Breitsprecher;Richa Jaiswal;Jeffrey P. Bombardier;Christopher J. Gould

  • Viewing dynamic assembly of molecular complexes by multi-wavelength single-molecule fluorescence.

    Larry J. Friedman;Johnson Chung;Jeff Gelles

  • Forward and Reverse Motion of Single RecBCD Molecules on DNA

    Thomas T. Perkins;Hung-Wen Li;Ravindra V. Dalal;Jeff Gelles

  • Mechanism of Transcription Initiation at an Activator-Dependent Promoter Defined by Single-Molecule Observation

    Larry J. Friedman;Jeff Gelles

  • Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

    Larry J. Friedman;Jeff Gelles;Simina Ticau;Nikola Ivica

Frequent Co-Authors

Robert Landick
Robert Landick University of Wisconsin–Madison
Melissa J. Moore
Melissa J. Moore University of Massachusetts Chan Medical School
Bruce L. Goode
Bruce L. Goode Brandeis University
Sunney I. Chan
Sunney I. Chan National Taiwan University
Steven M. Block
Steven M. Block Stanford University
Virginia W. Cornish
Virginia W. Cornish Columbia University
Stephen Buratowski
Stephen Buratowski Harvard University
Michael P. Sheetz
Michael P. Sheetz The University of Texas Medical Branch at Galveston
Ann Hochschild
Ann Hochschild Harvard University

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