World's Best Scientists 2026 revealed!
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Best Female Scientists
2025

D-Index & Metrics

Best Female Scientists

D-Index
115
Citations
65392
World Ranking
701
National Ranking
425

Biology and Biochemistry

D-Index
116
Citations
71210
World Ranking
737
National Ranking
468

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award

Overview

Xiaowei Zhuang is a researcher affiliated with Harvard University in the United States. Their work primarily falls within the broad discipline of Biochemistry, Genetics, and Molecular Biology, with a significant focus on Molecular Biology. Additional subfields of study include Biophysics, Immunology, Neurology, and Cancer Research.

The main topics covered in Zhuang's research encompass Single-cell and spatial transcriptomics, Immune cells in cancer, Neuroinflammation and Neurodegeneration Mechanisms, Cell Image Analysis Techniques, RNA Research and Splicing, Genomics and Chromatin Dynamics, and Advanced Fluorescence Microscopy Techniques.

Zhuang's publication record includes recent papers such as:

  • A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain, 2023, Nature
  • Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram, 2021, Nature Methods
  • Genome-Scale Imaging of the 3D Organization and Transcriptional Activity of Chromatin, 2020, Cell
  • A multimodal cell census and atlas of the mammalian primary motor cortex, 2021, Nature
  • Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma, 2021, Cancer Cell

Frequent co-authors collaborating with Zhuang include:

  • Timothy R. Blosser
  • Meng Zhang
  • Aviv Regev
  • Catherine Dulac
  • Stephen W. Eichhorn

Zhuang has published extensively in several scientific venues, with the most frequent outlets being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Cancer Research
  • Cell
  • Science

Best Publications

  • Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM).

    Michael J Rust;Mark Bates;Xiaowei Zhuang;Xiaowei Zhuang

  • Three-Dimensional Super-Resolution Imaging by Stochastic Optical Reconstruction Microscopy

    Bo Huang;Wenqin Wang;Mark Bates;Xiaowei Zhuang;Xiaowei Zhuang

  • Spatially resolved, highly multiplexed RNA profiling in single cells

    Kok Hao Chen;Alistair N. Boettiger;Jeffrey R. Moffitt;Siyuan Wang

  • Super-Resolution Fluorescence Microscopy

    Bo Huang;Mark Bates;Xiaowei Zhuang

  • Electrical detection of single viruses

    Fernando Patolsky;Gengfeng Zheng;Oliver Hayden;Melike Lakadamyali

  • Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging

    Graham T Dempsey;Joshua C Vaughan;Joshua C Vaughan;Kok Hao Chen;Mark Bates

  • Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region.

    Jeffrey R. Moffitt;Dhananjay Bambah-Mukku;Dhananjay Bambah-Mukku;Stephen W. Eichhorn;Eric Vaughn;Eric Vaughn

  • Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons

    Ke Xu;Guisheng Zhong;Xiaowei Zhuang;Xiaowei Zhuang

  • Breaking the Diffraction Barrier: Super-Resolution Imaging of Cells

    Bo Huang;Hazen Babcock;Xiaowei Zhuang;Xiaowei Zhuang

  • Mapping molecular orientation and conformation at interfaces by surface nonlinear optics

    X. Zhuang;X. Zhuang;P. B. Miranda;P. B. Miranda;D. Kim;D. Kim;Y. R. Shen;Y. R. Shen

  • A single-molecule study of RNA catalysis and folding.

    Xiaowei Zhuang;Laura E. Bartley;Hazen P. Babcock;Rick Russell

  • Fast, three-dimensional super-resolution imaging of live cells

    Sara A. Jones;Sang Hee Shim;Jiang-Tu He;Xiaowei Zhuang;Xiaowei Zhuang

  • Visualizing infection of individual influenza viruses.

    Melike Lakadamyali;Michael J. Rust;Hazen P. Babcock;Xiaowei Zhuang

  • Super-resolution imaging reveals distinct chromatin folding for different epigenetic states

    Alistair N. Boettiger;Bogdan Bintu;Jeffrey R. Moffitt;Siyuan Wang

  • Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells

    Bogdan Bintu;Leslie J. Mateo;Jun-Han Su;Nicholas A. Sinnott-Armstrong

  • Superresolution Imaging of Chemical Synapses in the Brain

    Adish Dani;Bo Huang;Bo Huang;Joseph Bergan;Joseph Bergan;Catherine Dulac;Catherine Dulac

  • Whole cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution

    Bo Huang;Sara A Jones;Boerries Brandenburg;Boerries Brandenburg;Xiaowei Zhuang;Xiaowei Zhuang

  • Ligands for Clathrin-Mediated Endocytosis Are Differentially Sorted into Distinct Populations of Early Endosomes

    Melike Lakadamyali;Michael J. Rust;Michael J. Rust;Xiaowei Zhuang;Xiaowei Zhuang

  • Correlating Structural Dynamics and Function in Single Ribozyme Molecules

    Xiaowei Zhuang;Harold Kim;Miguel J. B. Pereira;Hazen P. Babcock

  • Super-resolution imaging reveals distinct chromatin folding for different epigenetic states

    Alistair N. Boettiger;Bogdan Bintu;Jeffrey R. Moffitt;Siyuan Wang

Frequent Co-Authors

Aviv Regev
Aviv Regev Genentech
Steven Chu
Steven Chu Stanford University
David E. Clapham
David E. Clapham Howard Hughes Medical Institute
Vann Bennett
Vann Bennett Duke University
Catherine Dulac
Catherine Dulac Howard Hughes Medical Institute
Taekjip Ha
Taekjip Ha Johns Hopkins University
Bing Ren
Bing Ren New York Genome Center
Stephen Z. D. Cheng
Stephen Z. D. Cheng University of Akron

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