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Derek C. Radisky

Derek C. Radisky

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
23417
World Ranking
4291
National Ranking
2096

Overview

Derek C. Radisky is affiliated with the Mayo Clinic in the United States and has conducted extensive research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work prominently focuses on oncology and molecular biology, with a particular emphasis on cancer research, pathology, forensic medicine, and genetics.

The scientist's research themes cover various topics, including:

  • Cancer Cells and Metastasis
  • Breast Lesions and Carcinomas
  • Breast Cancer Treatment Studies
  • AI in cancer detection
  • Peptidase Inhibition and Analysis
  • Global Cancer Incidence and Screening
  • Cancer Genomics and Diagnostics

Derek C. Radisky has published frequently in well-known scientific venues. The main publication venues include:

  • Cancer Research (33 publications)
  • Breast Cancer Research and Treatment (5 publications)
  • Journal of Clinical and Translational Science (5 publications)
  • Cancers (4 publications)
  • Research Square (4 publications)

The scientist has coauthored many papers with several frequent collaborators. Notable coauthors are:

  • Amy C. Degnim (44 joint publications)
  • Mark E. Sherman (39 joint publications)
  • Stacey J. Winham (39 joint publications)
  • Robert A. Vierkant (36 joint publications)
  • Melody Stallings-Mann (26 joint publications)

Representative recent publications led by or including Derek C. Radisky cover diverse aspects of cancer biology and therapy:

  • "Aurora-A kinase oncogenic signaling mediates TGF-β-induced triple-negative breast cancer plasticity and chemoresistance", 2021, Oncogene
  • "Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition", 2025, Journal of Hematology & Oncology
  • "MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence", 2021, Cancer Letters
  • "Enhanced Antitumor Immunity via Endocrine Therapy Prevents Mammary Tumor Relapse and Increases Immune Checkpoint Blockade Sensitivity", 2020, Cancer Research
  • "Aberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma", 2022, Matrix Biology

This body of work spans from basic molecular mechanisms involved in tumor progression to exploration of therapeutic approaches targeting the tumor microenvironment and cancer cell plasticity. The scientist contributes to understanding cellular processes that influence tumor behavior, treatment resistance, and immune responses related to cancer recurrence and treatment sensitivity.

Best Publications

  • Putting tumours in context

    Mina J. Bissell;Derek Radisky

  • Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

    Derek C. Radisky;Dinah D. Levy;Laurie E. Littlepage;Hong Liu

  • The organizing principle: microenvironmental influences in the normal and malignant breast.

    Mina J. Bissell;Derek C. Radisky;Aylin Rizki;Valerie M. Weaver

  • Epithelial-mesenchymal transition

    Derek C. Radisky

  • Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer

    Evette S. Radisky;Derek C. Radisky

  • Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells

    Marta Santisteban;Jennifer M. Reiman;Michael K. Asiedu;Marshall D. Behrens

  • The microbiome of aseptically collected human breast tissue in benign and malignant disease

    Tina J. Hieken;Jun Chen;Tanya L. Hoskin;Marina Walther-Antonio

  • Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?

    Derek C. Radisky;Paraic A. Kenny;Mina J. Bissell

  • Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

    Christine Mehner;Alexandra Hockla;Erin Miller;Sophia Ran

  • Microenvironmental Regulators of Tissue Structure and Function Also Regulate Tumor Induction and Progression: The Role of Extracellular Matrix and Its Degrading Enzymes

    M.J. Bissell;P.A. Kenny;D.C. Radisky

  • The Yeast Frataxin Homologue Mediates Mitochondrial Iron Efflux: EVIDENCE FOR A MITOCHONDRIAL IRON CYCLE *

    Derek C. Radisky;Michael C. Babcock;Jerry Kaplan

  • Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts.

    Fei Wang;Rhonda K. Hansen;Derek Radisky;Toshiyuki Yoneda

  • TGFβ/TNFα-Mediated Epithelial–Mesenchymal Transition Generates Breast Cancer Stem Cells with a Claudin-Low Phenotype

    Michael K. Asiedu;James N. Ingle;Marshall D. Behrens;Derek C. Radisky

  • AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells.

    Michael K. Asiedu;Francis D. Beauchamp-Perez;James N. Ingle;Marshall D. Behrens

  • Epithelial-Mesenchymal Transition: General Principles and Pathological Relevance with Special Emphasis on the Role of Matrix Metalloproteinases

    Paola Nisticò;Mina J. Bissell;Derek C. Radisky

  • Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development

    Lidiya S. Orlichenko;Derek C. Radisky

  • Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?

    Eva A Turley;Mandana Veiseh;Derek C Radisky;Mina J Bissell

  • Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells

    Hong-Hong Liu;Derek C. Radisky;Fei Wang;Mina J. Bissell

  • Biomedical Potential of Marine Natural Products

    Chris M. Ireland;Brent R. Copp;Mark P. Foster;Leonard A. McDonald

  • The organizing principle: microenvironmental influences in the normal and malignant breast

    Mina Bissell

Frequent Co-Authors

Lynn C. Hartmann
Lynn C. Hartmann Mayo Clinic
Mina J. Bissell
Mina J. Bissell Lawrence Berkeley National Laboratory
Celeste M. Nelson
Celeste M. Nelson Princeton University
Celine M. Vachon
Celine M. Vachon Mayo Clinic
Keith L. Knutson
Keith L. Knutson Mayo Clinic
Mark E. Sherman
Mark E. Sherman Mayo Clinic
Yan W. Asmann
Yan W. Asmann Mayo Clinic
Edith A. Perez
Edith A. Perez Mayo Clinic
V. Shane Pankratz
V. Shane Pankratz University of New Mexico

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