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Keith L. Knutson

Keith L. Knutson

D-Index & Metrics

Immunology

D-Index
68
Citations
25288
World Ranking
2544
National Ranking
1218

Overview

Keith L. Knutson is affiliated with the Mayo Clinic in the United States and has contributed extensively to the field of medicine, with a primary focus on oncology. Their research spans various specialized subfields including oncology, immunology, cancer research, radiology, nuclear medicine and imaging, and infectious diseases.

The scientist's work covers multiple topics central to cancer biology and treatment approaches. These topics include:

  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • HER2/EGFR in Cancer Research
  • SARS-CoV-2 and COVID-19 Research
  • Cancer Genomics and Diagnostics
  • Monoclonal and Polyclonal Antibodies Research
  • CAR-T cell therapy research

Keith L. Knutson's publications frequently appear in notable scientific journals, indicating active engagement in cutting-edge oncology research. The most common publication venues include:

  • Cancer Research
  • Journal of Clinical Oncology
  • Clinical Cancer Research
  • Journal for ImmunoTherapy of Cancer
  • bioRxiv (Cold Spring Harbor Laboratory)

Among their recent papers are studies addressing immunotherapy and cancer treatment resistance, such as:

  • Margetuximab plus pembrolizumab in patients with previously treated, HER2-positive gastro-oesophageal adenocarcinoma (CP-MGAH22-05): a single-arm, phase 1b-2 trial, 2020, The Lancet Oncology
  • Th17-inducing autologous dendritic cell vaccination promotes antigen-specific cellular and humoral immunity in ovarian cancer patients, 2020, Nature Communications
  • Folate receptor alpha expression associates with improved disease-free survival in triple negative breast cancer patients, 2020, npj Breast Cancer
  • Resistance to Trastuzumab, 2022, Cancers
  • Safety, immunogenicity, and clinical efficacy of durvalumab in combination with folate receptor alpha vaccine TPIV200 in patients with advanced ovarian cancer: a phase II trial, 2020, Journal for ImmunoTherapy of Cancer

Collaborative research is a notable aspect of Keith L. Knutson's career. Frequent coauthors include:

  • Saranya Chumsri
  • Alvaro Moreno-Aspitia
  • Brian M. Necela
  • Matthew P. Goetz
  • E. Aubrey Thompson

Keith L. Knutson's body of work demonstrates a multidisciplinary approach, integrating immunological strategies with oncology to address complex challenges in cancer treatment and biomarker discovery.

Best Publications

  • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.

    Tyler J Curiel;George Coukos;Linhua Zou;Xavier Alvarez

  • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity.

    Tyler J Curiel;Shuang Wei;Haidong Dong;Xavier Alvarez

  • Tumor antigen-specific T helper cells in cancer immunity and immunotherapy.

    K. L. Knutson;M. L. Disis

  • Next generation of immune checkpoint therapy in cancer: new developments and challenges

    Julian A. Marin-Acevedo;Bhagirathbhai Dholaria;Aixa E. Soyano;Keith L. Knutson

  • Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients

    Keith L. Knutson;Kathy Schiffman;Mary L. Disis

  • Folate receptor alpha as a tumor target in epithelial ovarian cancer

    Kimberly R. Kalli;Ann L. Oberg;Gary L. Keeney;Teresa J.H. Christianson

  • Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines

    Mary L. Disis;Theodore A. Gooley;Kristine Rinn;Donna Davis

  • Tumor-Infiltrating Dendritic Cells in Cancer Pathogenesis

    Jo Marie Tran Janco;Purushottam Lamichhane;Lavakumar Karyampudi;Keith L. Knutson

  • Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells

    Marta Santisteban;Jennifer M. Reiman;Michael K. Asiedu;Marshall D. Behrens

  • The microbiome of aseptically collected human breast tissue in benign and malignant disease

    Tina J. Hieken;Jun Chen;Tanya L. Hoskin;Marina Walther-Antonio

  • Rheumatoid Arthritis and Cardiovascular Disease

    Cynthia S. Crowson;Katherine P. Liao;John M. Davis;Daniel H. Solomon

  • Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma

    Frank A. Sinicrope;Rafaela L. Rego;Stephen M. Ansell;Keith L. Knutson

  • Immunization of Cancer Patients with a HER-2/neu, HLA-A2 Peptide, p369–377, Results in Short-lived Peptide-specific Immunity

    Keith L. Knutson;Kathy Schiffman;Martin A. Cheever;Mary L. Disis

  • TGFβ/TNFα-Mediated Epithelial–Mesenchymal Transition Generates Breast Cancer Stem Cells with a Claudin-Low Phenotype

    Michael K. Asiedu;James N. Ingle;Marshall D. Behrens;Derek C. Radisky

  • AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells.

    Michael K. Asiedu;Francis D. Beauchamp-Perez;James N. Ingle;Marshall D. Behrens

  • Tumor-Infiltrating Programmed Death Receptor-1 + Dendritic Cells Mediate Immune Suppression in Ovarian Cancer

    James Krempski;Lavakumar Karyampudi;Marshall D. Behrens;Courtney L. Erskine

  • Tumor immunoediting and immunosculpting pathways to cancer progression.

    Jennifer M. Reiman;Maciej Kmieciak;Masoud H. Manjili;Keith L. Knutson

  • The Ratios of CD8+ T Cells to CD4+CD25+ FOXP3+ and FOXP3- T Cells Correlate with Poor Clinical Outcome in Human Serous Ovarian Cancer

    Claudia C. Preston;Matthew J. Maurer;Ann L. Oberg;Daniel W. Visscher

  • Augmented HER-2-specific immunity during treatment with trastuzumab and chemotherapy

    Clare Taylor;Dawn Hershman;Nina Shah;Nicole Suciu-Foca

  • Tumor-Infiltrating Foxp3−CD4+CD25+ T Cells Predict Poor Survival in Renal Cell Carcinoma

    Sameer A. Siddiqui;Xavier Frigola;Sandra Bonne-Annee;Maria Mercader

Frequent Co-Authors

Mary L. Disis
Mary L. Disis University of Washington
Ellen L. Goode
Ellen L. Goode Mayo Clinic
Lynn C. Hartmann
Lynn C. Hartmann Mayo Clinic
Derek C. Radisky
Derek C. Radisky Mayo Clinic
Edith A. Perez
Edith A. Perez Mayo Clinic
James N. Ingle
James N. Ingle Mayo Clinic

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