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Biology and Biochemistry

D-Index
78
Citations
19329
World Ranking
4603
National Ranking
2238

Overview

Ruth B. Caldwell is affiliated with Augusta University in the United States. Their research spans several fields with a primary focus on Medicine as well as Biochemistry, Genetics, and Molecular Biology. Within these broad fields, Caldwell's work frequently addresses subfields such as Ophthalmology, Molecular Biology, Neurology, Physiology, and Immunology.

The scientist's research topics predominantly cover retinal and neurological conditions, including:

  • Retinal Diseases and Treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Nitric Oxide and Endothelin Effects
  • Retinal Development and Disorders
  • Trace Elements in Health
  • Immune cells in cancer
  • Angiogenesis and VEGF in Cancer

Caldwell has contributed to several recent papers with notable publications in well-regarded journals. These include:

  • "Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis," published in Nature Cell Biology in 2022
  • "Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche," Science Translational Medicine, 2020
  • "Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy," JCI Insight, 2022
  • "Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction," Molecular Metabolism, 2021
  • "Suppression of myeloid PFKFB3-driven glycolysis protects mice from choroidal neovascularization," British Journal of Pharmacology, 2022

The venues where Caldwell most frequently publishes include:

  • Journal of Clinical Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Free Radical Biology and Medicine
  • Cell Death and Disease
  • Investigative Ophthalmology & Visual Science

Caldwell's research collaborations demonstrate ongoing partnerships with frequently coauthoring scientists, including Zhimin Xu, Robert W. Caldwell, Abdelrahman Y. Fouda, Syed Zaidi, and Tahira Lemtalsi. These collaborations indicate a networked approach to research in related areas of molecular biology and ophthalmology.

Best Publications

  • Corneal avascularity is due to soluble VEGF receptor-1

    Balamurali K. Ambati;Miho Nozaki;Nirbhai Singh;Atsunobu Takeda

  • Vascular endothelial growth factor in eye disease.

    J.S. Penn;A. Madan;R.B. Caldwell;M. Bartoli

  • Vascular Endothelial Growth Factor Signals Endothelial Cell Production of Nitric Oxide and Prostacyclin Through flk-1/KDR Activation of c-Src

    Han He;Virginia J. Venema;Xiaolin Gu;Richard C. Venema

  • Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions.

    Wayne H. Kaesemeyer;Ruth B. Caldwell;Jianzhong Huang;R.William Caldwell

  • Diabetes-induced Coronary Vascular Dysfunction Involves Increased Arginase Activity

    Maritza J. Romero;Daniel H. Platt;Huda E. Tawfik;Mohamed Labazi

  • Arginase: A Multifaceted Enzyme Important in Health and Disease.

    R. William Caldwell;Paulo C. Rodriguez;Haroldo A. Toque;S. Priya Narayanan

  • Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives

    Ruth B. Caldwell;Manuela Bartoli;M. Ali Behzadian;Azza E. B. El-Remessy

  • Arginase: an old enzyme with new tricks.

    Ruth B. Caldwell;Ruth B. Caldwell;Haroldo A. Toque;S. Priya Narayanan;R. William Caldwell

  • Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes

    Azza B. El-Remessy;Mohamed Al-Shabrawey;Yousuf Khalifa;Nai Tse Tsai

  • Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress.

    Ruth B. Caldwell;Manuela Bartoli;M. Ali Behzadian;Azza E.B. El-Remessy

  • Experimental Diabetes Causes Breakdown of the Blood-Retina Barrier by a Mechanism Involving Tyrosine Nitration and Increases in Expression of Vascular Endothelial Growth Factor and Urokinase Plasminogen Activator Receptor

    Azza B. El-Remessy;M. Ali Behzadian;Gamal Abou-Mohamed;Telina Franklin

  • Therapeutic Use of Citrulline in Cardiovascular Disease

    Maritza J. Romero;Daniel H. Platt;Ruth B. Caldwell;R. William Caldwell

  • Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity : Involvement of Peroxynitrite

    Azza B. El-Remessy;Ibrahim E. Khalil;Suraporn Matragoon;Gamal Abou-Mohamed

  • TGF-β increases retinal endothelial cell permeability by increasing MMP-9 : Possible role of glial cells in endothelial barrier function

    M A Behzadian;X L Wang;L J Windsor;N Ghaly

  • Endothelial PFKFB3 Plays a Critical Role in Angiogenesis

    Yiming Xu;Xiaofei An;Xiaofei An;Xin Guo;Tsadik Ghebreamlak Habtetsion

  • Role of NADPH oxidase in retinal vascular inflammation.

    Mohamed Al-Shabrawey;Modesto Rojas;Tammy Sanders;Ali Behzadian

  • Nonvascular role for VEGF: VEGFR-1, 2 activity is critical for neural retinal development

    Gregory S. Robinson;Meihua Ju;Shu-Ching Shih;X. Xu

  • VEGF differentially activates STAT3 in microvascular endothelial cells.

    Manuela Bartoli;Daniel H. Platt;Tahira Lemtalsi;Xiaolin Gu

  • Inhibition of NAD(P)H Oxidase Activity Blocks Vascular Endothelial Growth Factor Overexpression and Neovascularization during Ischemic Retinopathy

    Mohamed Al-Shabrawey;Manuela Bartoli;Azza B. El-Remessy;Daniel H. Platt

  • Neuroprotective and Blood–Retinal Barrier–Preserving Effects of Cannabidiol in Experimental Diabetes

    G.I. Liou;A.B. El–Remessy;M. Al–Shabrawey;Y. Khalifa

Frequent Co-Authors

David Fulton
David Fulton Augusta University
Sylvia B. Smith
Sylvia B. Smith Augusta University
Rudolf Lucas
Rudolf Lucas Augusta University
R. Clinton Webb
R. Clinton Webb Augusta University
Yuqing Huo
Yuqing Huo Augusta University
Richard C. Venema
Richard C. Venema Augusta University
Lois E. H. Smith
Lois E. H. Smith Boston Children's Hospital
Stephen D. Cederbaum
Stephen D. Cederbaum University of California, Los Angeles
John D. Catravas
John D. Catravas Old Dominion University
Yutao Liu
Yutao Liu Augusta University

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