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Manabu Negishi

Manabu Negishi

D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
20196
World Ranking
5309
National Ranking
346

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Signal transduction

His primary areas of investigation include Cell biology, Signal transduction, GTPase, Receptor and Neurite. His research investigates the connection with Cell biology and areas like Semaphorin which intersect with concerns in Guanine nucleotide exchange factor. His work is dedicated to discovering how Signal transduction, cDNA library are connected with Tetratricopeptide, Phosphatase, G beta-gamma complex, Effector and Prostacyclin receptor and other disciplines.

As part of his studies on GTPase, he frequently links adjacent subjects like G protein. His Receptor research incorporates elements of Endocrinology and Gene isoform. His Unfolded protein response study combines topics from a wide range of disciplines, such as Serine protease, Molecular biology, Transcription factor and Activating transcription factor 2.

His most cited work include:

  • ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to the cis-Acting Element Responsible for the Mammalian Unfolded Protein Response (770 citations)
  • Failure of Parturition in Mice Lacking the Prostaglandin F Receptor (522 citations)
  • Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. (443 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Cell biology, Receptor, Molecular biology, Endocrinology and Biochemistry. Cell biology is closely attributed to Neurite in his research. His Receptor research includes elements of Prostaglandin and Gene isoform.

His Molecular biology research includes themes of Gene expression, Complementary DNA, Unfolded protein response, Endoplasmic reticulum and Nuclear protein. His research in the fields of Chromaffin cell, Prostaglandin E2 and Catecholamine overlaps with other disciplines such as Ouabain. His research investigates the connection between GTPase and topics such as Semaphorin that intersect with issues in GTPase-activating protein.

He most often published in these fields:

  • Cell biology (46.67%)
  • Receptor (23.81%)
  • Molecular biology (21.90%)

What were the highlights of his more recent work (between 2006-2019)?

  • Cell biology (46.67%)
  • RhoG (7.62%)
  • Small GTPase (10.95%)

In recent papers he was focusing on the following fields of study:

Manabu Negishi mostly deals with Cell biology, RhoG, Small GTPase, Phosphorylation and Hippocampal formation. His studies deal with areas such as Dendritic spine and Cancer cell as well as Cell biology. His Small GTPase research integrates issues from Molecular biology and Biological neural network.

His study in Molecular biology is interdisciplinary in nature, drawing from both Receptor, Neurite and Kinase. His work focuses on many connections between Receptor and other disciplines, such as Endocrinology, that overlap with his field of interest in Cellular differentiation. He has researched GTPase in several fields, including Semaphorin and Plexin.

Between 2006 and 2019, his most popular works were:

  • Interaction of arginine-rich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis. (320 citations)
  • Rac-GAP α-Chimerin Regulates Motor-Circuit Formation as a Key Mediator of EphrinB3/EphA4 Forward Signaling (135 citations)
  • Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism (99 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Amino acid

His main research concerns Cell biology, Semaphorin, GTPase, PI3K/AKT/mTOR pathway and Plexin. Manabu Negishi combines topics linked to Hippocampal formation with his work on Cell biology. His Semaphorin study integrates concerns from other disciplines, such as Cancer research and Signal transduction.

His Signal transduction research is multidisciplinary, relying on both Cell migration and Cell adhesion. His biological study spans a wide range of topics, including Anoikis and Protein kinase B, Phosphorylation. His Kinase research includes elements of Molecular biology and Glycogen synthase.

Best Publications

  • ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to the cis-Acting Element Responsible for the Mammalian Unfolded Protein Response

    Hiderou Yoshida;Tetsuya Okada;Kyosuke Haze;Hideki Yanagi

  • Failure of Parturition in Mice Lacking the Prostaglandin F Receptor

    Yukihiko Sugimoto;Atsushi Yamasaki;Eri Segi;Kazuhito Tsuboi

  • Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity.

    Tsunehisa Namba;Yukihiko Sugimoto;Manabu Negishi;Atsushi Irie

  • Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response.

    Tetsuya Okada;Hiderou Yoshida;Rieko Akazawa;Manabu Negishi

  • Molecular mechanisms of diverse actions of prostanoid receptors

    Manabu Negishi;Yukihiko Sugimoto;Atsushi Ichikawa

  • Interaction of arginine-rich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis.

    Ikuhiko Nakase;Akiko Tadokoro;Noriko Kawabata;Toshihide Takeuchi

  • The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras.

    Izumi Oinuma;Yukio Ishikawa;Hironori Katoh;Manabu Negishi

  • RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.

    Hironori Katoh;Manabu Negishi

  • Endoplasmic Reticulum Stress-Induced Formation of Transcription Factor Complex ERSF Including NF-Y (CBF) and Activating Transcription Factors 6α and 6β That Activates the Mammalian Unfolded Protein Response

    Hiderou Yoshida;Tetsuya Okada;Kyosuke Haze;Hideki Yanagi

  • cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla.

    T Namba;H Oida;Y Sugimoto;A Kakizuka

  • Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

    Kyosuke Haze;Tetsuya Okada;Hiderou Yoshida;Hideki Yanagi

  • Direct linkage of three tachykinin receptors to stimulation of both phosphatidylinositol hydrolysis and cyclic AMP cascades in transfected Chinese hamster ovary cells.

    Y Nakajima;K Tsuchida;M Negishi;S Ito

  • The Rostral Raphe Pallidus Nucleus Mediates Pyrogenic Transmission from the Preoptic Area

    Kazuhiro Nakamura;Kiyoshi Matsumura;Takeshi Kaneko;Shigeo Kobayashi

  • Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins.

    Yukihiko Sugimoto;Manabu Negishi;Yasunori Hayashi;Tsunehisa Namba

  • Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist

    N Nishigaki;M Negishi;A Ichikawa

  • A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.

    Tetsuya Okada;Kyosuke Haze;Satomi Nadanaka;Hiderou Yoshida;Hiderou Yoshida

  • RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway.

    Yoshiaki Yamaguchi;Hironori Katoh;Hidekazu Yasui;Kazutoshi Mori

  • Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system.

    Kazuhiro Nakamura;Takeshi Kaneko;Yoko Yamashita;Hiroshi Hasegawa

  • p160 RhoA-binding kinase ROKalpha induces neurite retraction.

    Hironori Katoh;Junko Aoki;Atsushi Ichikawa;Manabu Negishi

  • The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and Northern blot analysis

    Masato Katsuyama;Nobuhiro Nishigaki;Yukihiko Sugimoto;Kimiko Morimoto

Frequent Co-Authors

Hironori Katoh
Hironori Katoh Kyoto University
Atsushi Ichikawa
Atsushi Ichikawa Mukogawa Women's University
Yukihiko Sugimoto
Yukihiko Sugimoto Kumamoto University
Seiji Ito
Seiji Ito Kansai Medical University
Shuh Narumiya
Shuh Narumiya Kyoto University
Kazutoshi Mori
Kazutoshi Mori Kyoto University
Hiroshi Hasegawa
Hiroshi Hasegawa Kanazawa University
Kazuhiro Nakamura
Kazuhiro Nakamura Nagoya University
Osamu Hayaishi
Osamu Hayaishi Osaka Bioscience Institute
Hiderou Yoshida
Hiderou Yoshida University of Hyogo

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