World's Best Scientists 2026 revealed!
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Manabu Negishi

Manabu Negishi

Kyoto University
Japan

D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
20196
World Ranking
5309
National Ranking
346

Manabu Negishi publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Manabu Negishi sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 233 publications — 62nd percentile

62% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Manabu Negishi D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Manabu Negishi sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 75 D-Index — 74th percentile

74% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Signal transduction

His primary areas of investigation include Cell biology, Signal transduction, GTPase, Receptor and Neurite. His research investigates the connection with Cell biology and areas like Semaphorin which intersect with concerns in Guanine nucleotide exchange factor. His work is dedicated to discovering how Signal transduction, cDNA library are connected with Tetratricopeptide, Phosphatase, G beta-gamma complex, Effector and Prostacyclin receptor and other disciplines.

As part of his studies on GTPase, he frequently links adjacent subjects like G protein. His Receptor research incorporates elements of Endocrinology and Gene isoform. His Unfolded protein response study combines topics from a wide range of disciplines, such as Serine protease, Molecular biology, Transcription factor and Activating transcription factor 2.

His most cited work include:

  • ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to the cis-Acting Element Responsible for the Mammalian Unfolded Protein Response (770 citations)
  • Failure of Parturition in Mice Lacking the Prostaglandin F Receptor (522 citations)
  • Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. (443 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Cell biology, Receptor, Molecular biology, Endocrinology and Biochemistry. Cell biology is closely attributed to Neurite in his research. His Receptor research includes elements of Prostaglandin and Gene isoform.

His Molecular biology research includes themes of Gene expression, Complementary DNA, Unfolded protein response, Endoplasmic reticulum and Nuclear protein. His research in the fields of Chromaffin cell, Prostaglandin E2 and Catecholamine overlaps with other disciplines such as Ouabain. His research investigates the connection between GTPase and topics such as Semaphorin that intersect with issues in GTPase-activating protein.

He most often published in these fields:

  • Cell biology (46.67%)
  • Receptor (23.81%)
  • Molecular biology (21.90%)

What were the highlights of his more recent work (between 2006-2019)?

  • Cell biology (46.67%)
  • RhoG (7.62%)
  • Small GTPase (10.95%)

In recent papers he was focusing on the following fields of study:

Manabu Negishi mostly deals with Cell biology, RhoG, Small GTPase, Phosphorylation and Hippocampal formation. His studies deal with areas such as Dendritic spine and Cancer cell as well as Cell biology. His Small GTPase research integrates issues from Molecular biology and Biological neural network.

His study in Molecular biology is interdisciplinary in nature, drawing from both Receptor, Neurite and Kinase. His work focuses on many connections between Receptor and other disciplines, such as Endocrinology, that overlap with his field of interest in Cellular differentiation. He has researched GTPase in several fields, including Semaphorin and Plexin.

Between 2006 and 2019, his most popular works were:

  • Interaction of arginine-rich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis. (320 citations)
  • Rac-GAP α-Chimerin Regulates Motor-Circuit Formation as a Key Mediator of EphrinB3/EphA4 Forward Signaling (135 citations)
  • Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism (99 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Amino acid

His main research concerns Cell biology, Semaphorin, GTPase, PI3K/AKT/mTOR pathway and Plexin. Manabu Negishi combines topics linked to Hippocampal formation with his work on Cell biology. His Semaphorin study integrates concerns from other disciplines, such as Cancer research and Signal transduction.

His Signal transduction research is multidisciplinary, relying on both Cell migration and Cell adhesion. His biological study spans a wide range of topics, including Anoikis and Protein kinase B, Phosphorylation. His Kinase research includes elements of Molecular biology and Glycogen synthase.

Best Publications

  • ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to the cis-Acting Element Responsible for the Mammalian Unfolded Protein Response

    Hiderou Yoshida;Tetsuya Okada;Kyosuke Haze;Hideki Yanagi

  • Failure of Parturition in Mice Lacking the Prostaglandin F Receptor

    Yukihiko Sugimoto;Atsushi Yamasaki;Eri Segi;Kazuhito Tsuboi

  • Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity.

    Tsunehisa Namba;Yukihiko Sugimoto;Manabu Negishi;Atsushi Irie

  • Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response.

    Tetsuya Okada;Hiderou Yoshida;Rieko Akazawa;Manabu Negishi

  • Molecular mechanisms of diverse actions of prostanoid receptors

    Manabu Negishi;Yukihiko Sugimoto;Atsushi Ichikawa

  • Interaction of arginine-rich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis.

    Ikuhiko Nakase;Akiko Tadokoro;Noriko Kawabata;Toshihide Takeuchi

  • The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras.

    Izumi Oinuma;Yukio Ishikawa;Hironori Katoh;Manabu Negishi

  • RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.

    Hironori Katoh;Manabu Negishi

  • Endoplasmic Reticulum Stress-Induced Formation of Transcription Factor Complex ERSF Including NF-Y (CBF) and Activating Transcription Factors 6α and 6β That Activates the Mammalian Unfolded Protein Response

    Hiderou Yoshida;Tetsuya Okada;Kyosuke Haze;Hideki Yanagi

  • cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla.

    T Namba;H Oida;Y Sugimoto;A Kakizuka

  • Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

    Kyosuke Haze;Tetsuya Okada;Hiderou Yoshida;Hideki Yanagi

  • Direct linkage of three tachykinin receptors to stimulation of both phosphatidylinositol hydrolysis and cyclic AMP cascades in transfected Chinese hamster ovary cells.

    Y Nakajima;K Tsuchida;M Negishi;S Ito

  • The Rostral Raphe Pallidus Nucleus Mediates Pyrogenic Transmission from the Preoptic Area

    Kazuhiro Nakamura;Kiyoshi Matsumura;Takeshi Kaneko;Shigeo Kobayashi

  • Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins.

    Yukihiko Sugimoto;Manabu Negishi;Yasunori Hayashi;Tsunehisa Namba

  • Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist

    N Nishigaki;M Negishi;A Ichikawa

  • A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.

    Tetsuya Okada;Kyosuke Haze;Satomi Nadanaka;Hiderou Yoshida;Hiderou Yoshida

  • RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway.

    Yoshiaki Yamaguchi;Hironori Katoh;Hidekazu Yasui;Kazutoshi Mori

  • Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system.

    Kazuhiro Nakamura;Takeshi Kaneko;Yoko Yamashita;Hiroshi Hasegawa

  • p160 RhoA-binding kinase ROKalpha induces neurite retraction.

    Hironori Katoh;Junko Aoki;Atsushi Ichikawa;Manabu Negishi

  • The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and Northern blot analysis

    Masato Katsuyama;Nobuhiro Nishigaki;Yukihiko Sugimoto;Kimiko Morimoto

Frequent Co-Authors

Hironori Katoh
Hironori Katoh Kyoto University
Atsushi Ichikawa
Atsushi Ichikawa Mukogawa Women's University
Yukihiko Sugimoto
Yukihiko Sugimoto Kumamoto University
Seiji Ito
Seiji Ito Kansai Medical University
Shuh Narumiya
Shuh Narumiya Kyoto University
Kazutoshi Mori
Kazutoshi Mori Kyoto University
Hiroshi Hasegawa
Hiroshi Hasegawa Kanazawa University
Kazuhiro Nakamura
Kazuhiro Nakamura Nagoya University
Osamu Hayaishi
Osamu Hayaishi Osaka Bioscience Institute
Hiderou Yoshida
Hiderou Yoshida University of Hyogo

External Links

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Best Scientists Citing Manabu Negishi

Yukihiko Sugimoto

Yukihiko Sugimoto

Kumamoto University

Publications: 102

Shuh Narumiya

Shuh Narumiya

Kyoto University

Publications: 91

Atsushi Ichikawa

Atsushi Ichikawa

Mukogawa Women's University

Publications: 73

Kazutoshi Mori

Kazutoshi Mori

Kyoto University

Publications: 56

Richard M. Breyer

Richard M. Breyer

Vanderbilt University Medical Center

Publications: 50

Randal J. Kaufman

Randal J. Kaufman

Sanford Burnham Prebys Medical Discovery Institute

Publications: 46

Stefan Offermanns

Stefan Offermanns

Max Planck Society

Publications: 44

Hiderou Yoshida

Hiderou Yoshida

University of Hyogo

Publications: 42

Shaun F. Morrison

Shaun F. Morrison

Oregon Health & Science University

Publications: 38

Kazuhiro Nakamura

Kazuhiro Nakamura

Nagoya University

Publications: 38

Shiroh Futaki

Shiroh Futaki

Kyoto University

Publications: 38

Kozo Kaibuchi

Kozo Kaibuchi

Nagoya University

Publications: 31

Luca Tamagnone

Luca Tamagnone

Catholic University of the Sacred Heart

Publications: 30

Seiji Ito

Seiji Ito

Kansai Medical University

Publications: 29

Atsushi Kumanogoh

Atsushi Kumanogoh

Osaka University

Publications: 27

Garret A. FitzGerald

Garret A. FitzGerald

University of Pennsylvania

Publications: 24

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