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Francisco Ciruela

Francisco Ciruela

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Biology and Biochemistry
Spain
2023

D-Index & Metrics

Neuroscience

D-Index
79
Citations
17342
World Ranking
1715
National Ranking
21

Biology and Biochemistry

D-Index
79
Citations
17268
World Ranking
4411
National Ranking
51

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Spain Leader Award

Overview

Francisco Ciruela is affiliated with the University of Barcelona in Spain. Their research contributions span the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience, with a particular focus on Molecular Biology, Cellular and Molecular Neuroscience, Physiology, Cardiology and Cardiovascular Medicine, and Pharmacology.

Their main research topics include Adenosine and Purinergic Signaling, Receptor Mechanisms and Signaling, Neuroscience and Neuropharmacology Research, Neuropeptides and Animal Physiology, Cannabis and Cannabinoid Research, Pharmacological Receptor Mechanisms and Effects, and Photochromic and Fluorescence Chemistry.

Francisco Ciruela has published research in several frequent venues, notably Frontiers in Pharmacology, International Journal of Molecular Sciences, Biomedicine & Pharmacotherapy, Journal of Medicinal Chemistry, and Neural Regeneration Research.

Some recent research papers by Ciruela include:

  • Control of glutamate release by complexes of adenosine and cannabinoid receptors (2020), BMC Biology
  • G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs) (2021), Pharmacology & Therapeutics
  • Presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum (2022), Neuropharmacology
  • Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia (2020), Neuropsychopharmacology
  • Functional and pharmacological role of the dopamine D4 receptor and its polymorphic variants (2022), Frontiers in Endocrinology

They have frequently collaborated with co-authors such as Víctor Fernández-Dueñas, Ester Aso, Marc López-Cano, Sergi Ferré, and Josep Argerich.

Francisco Ciruela has contributed to academic literature beyond journal publications, including book publications through Humana Press. Notably, the book titled Receptor and Ion Channel Detection in the Brain was published in 2021.

Best Publications

  • Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers

    Francisco Ciruela;Vicent Casadó;Ricardo J. Rodrigues;Rafael Luján

  • Adenosine A2A-Dopamine D2 Receptor-Receptor Heteromerization QUALITATIVE AND QUANTITATIVE ASSESSMENT BY FLUORESCENCE AND BIOLUMINESCENCE ENERGY TRANSFER

    Meritxell Canals;Daniel Marcellino;Francesca Fanelli;Francisco Ciruela

  • Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.

    Sergi Ferré;Marzena Karcz-Kubicha;Bruce T. Hope;Patrizia Popoli

  • Detection of heteromerization of more than two proteins by sequential BRET-FRET.

    Paulina Carriba;Gemma Navarro;Francisco Ciruela;Sergi Ferré

  • METABOTROPIC GLUTAMATE TYPE 5, DOPAMINE D2 AND ADENOSINE A2A RECEPTORS FORM HIGHER-ORDER OLIGOMERS IN LIVING CELLS

    Nuria Cabello;Jorge Gandía;Daniela C. G. Bertarelli;Masahiko Watanabe

  • Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids.

    Paulina Carriba;Oskar Ortiz;Kshitij Patkar;Zuzana Justinova;Zuzana Justinova

  • Cell surface adenosine deaminase: Much more than an ectoenzyme

    Rafael Franco;Vicent Casadó;Francisco Ciruela;Carles Saura

  • Receptor heteromerization in adenosine A2A receptor signaling Relevance for striatal function and Parkinson’s disease

    Kjell Fuxe;L. F. Agnati;K. Jacobsen;J. Hillion

  • An Update on Adenosine A2A-Dopamine D2 Receptor Interactions: Implications for the Function of G Protein-Coupled Receptors

    Sergi Ferré;César Quiroz;A S Woods;Rodrigo Antunes Cunha

  • Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors.

    Francisco Ciruela;Javier Burgueño;Vicent Casadó;Meritxell Canals

  • Metabotropic Glutamate 1α and Adenosine A1 Receptors Assemble into Functionally Interacting Complexes

    Francisco Ciruela;Francisco Ciruela;Marisol Escriche;Javier Burgueño;Ester Angulo

  • Fluorescence-based methods in the study of protein-protein interactions in living cells.

    Francisco Ciruela

  • The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx

    Julia H. White;R. A. Jeffrey McIllhinney;Alan Wise;Francisco Ciruela

  • Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer.

    Meritxell Canals;Javier Burgueño;Daniel Marcellino;Núria Cabello

  • ADENOSINE DEAMINASE AFFECTS LIGAND-INDUCED SIGNALLING BY INTERACTING WITH CELL SURFACE ADENOSINE RECEPTORS

    Francisco Ciruela;Carles Saura;Enric I. Canela;Josefa Mallol

  • Glutamate Released by Dendritic Cells as a Novel Modulator of T Cell Activation

    Rodrigo Pacheco;Harold Oliva;José M. Martinez-Navío;Núria Climent

  • Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain.

    Ferre S;Ciruela F;Borycz J;Solinas M

  • Immunological identification of A1 adenosine receptors in brain cortex

    F. Ciruela;V. Casadó;J. Mallol;E. I. Canela

  • Adenosine–Dopamine Interactions in the Pathophysiology and Treatment of CNS Disorders

    K. Fuxe;D. Marcellino;D. O. Borroto‐Escuela;M. Guescini

  • Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders

    Sergi Ferré;Francisco Ciruela;Meritxell Canals;Daniel Marcellino

  • Functional relevance of neurotransmitter receptor heteromers in the central nervous system.

    Sergi Ferré;Francisco Ciruela;Amina S. Woods;Carme Lluis

Frequent Co-Authors

Rafael Franco
Rafael Franco University of Barcelona
Kjell Fuxe
Kjell Fuxe Karolinska Institute
Sergi Ferré
Sergi Ferré National Institute on Drug Abuse
Carmen Lluis
Carmen Lluis University of Barcelona
Enric I. Canela
Enric I. Canela University of Barcelona
Luigi F. Agnati
Luigi F. Agnati University of Modena and Reggio Emilia
Dasiel O. Borroto-Escuela
Dasiel O. Borroto-Escuela Karolinska Institute
Josefa Mallol
Josefa Mallol University of Barcelona
Vicent Casadó
Vicent Casadó University of Barcelona
Rafael Luján
Rafael Luján University of Castilla-La Mancha

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