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Dasiel O. Borroto-Escuela

Dasiel O. Borroto-Escuela

D-Index & Metrics

Neuroscience

D-Index
49
Citations
7292
World Ranking
6050
National Ranking
119

Overview

Dasiel O. Borroto-Escuela is affiliated with the Karolinska Institute in Sweden. Their research primarily spans the fields of neuroscience as well as biochemistry, genetics, and molecular biology, with a strong focus on molecular biology and cellular and molecular neuroscience.

The scientist's work often addresses receptor mechanisms and signaling, neuropeptides and animal physiology, neuroscience and neuropharmacology research, neuroendocrine regulation and behavior, neurotransmitter receptor influence on behavior, neurogenesis and neuroplasticity mechanisms, and pharmacological receptor mechanisms and effects.

Notable recent publications include:

  • The Role of Central Serotonin Neurons and 5-HT Heteroreceptor Complexes in the Pathophysiology of Depression: A Historical Perspective and Future Prospects (2021) in International Journal of Molecular Sciences
  • The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior (2022) in Frontiers in Molecular Neuroscience

Other recent papers connected to this research sphere, though with different lead authors, are:

  • Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer (2020) in Oncogene
  • Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations (2020) in Neuropharmacology
  • Molecular, biochemical and behavioural evidence for a novel oxytocin receptor and serotonin 2C receptor heterocomplex (2020) in Neuropharmacology

Frequent co-authors in Borroto-Escuela's research include Kjell Fuxé, Manuel Narváez, Miguel Pérez de la Mora, Luca Ferraro, and Minerva Crespo-Ramírez. These collaborations correlate with a substantial number of joint publications, particularly with Fuxé and Narváez.

Common publication venues where Borroto-Escuela's work appears are:

  • Frontiers in Pharmacology
  • Cells
  • Pharmacological Reports
  • International Journal of Molecular Sciences
  • Frontiers in Molecular Neuroscience

The scientist's research topics consistently explore receptor interactions involved in brain function and behavior, emphasizing molecular complexes such as serotonin and oxytocin receptors and their roles in neurological processes. This body of work crosses interdisciplinary boundaries linking cellular signaling, neurophysiology, and behavioral outcomes.

Best Publications

  • Evidence for the existence of dopamine D2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor-receptor interactions.

    W Romero-Fernandez;D O Borroto-Escuela;L F Agnati;K Fuxe

  • Adenosine–Dopamine Interactions in the Pathophysiology and Treatment of CNS Disorders

    K. Fuxe;D. Marcellino;D. O. Borroto‐Escuela;M. Guescini

  • The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components

    Dasiel O. Borroto-Escuela;Ismel Brito;Wilber Romero-Fernandez;Michael Di Palma

  • Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia

    Gemma Navarro;Dasiel Borroto-Escuela;Edgar Angelats;Íñigo Etayo

  • Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease.

    Dasiel O. Borroto-Escuela;Jens Carlsson;Patricia Ambrogini;Manuel Narvaez

  • Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity.

    Dasiel O. Borroto-Escuela;Wilber Romero-Fernandez;Giuseppa Mudó;Mileidys Pérez-Alea

  • Volume Transmission in Central Dopamine and Noradrenaline Neurons and Its Astroglial Targets

    Kjell Fuxe;Luigi F. Agnati;Manuela Marcoli;Dasiel O. Borroto-Escuela

  • The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural-glial networks.

    Dasiel O. Borroto-Escuela;Luigi F. Agnati;Karl Bechter;Anders Jansson

  • G Protein–Coupled Receptor Heterodimerization in the Brain

    Dasiel O. Borroto-Escuela;Wilber Romero-Fernandez;Pere Garriga;Francisco Ciruela

  • Dopamine D2 and 5-hydroxytryptamine 5-HT2A receptors assemble into functionally interacting heteromers

    Dasiel O. Borroto-Escuela;Wilber Romero-Fernandez;Alexander O. Tarakanov;Daniel Marcellino

  • Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions.

    Dasiel O. Borroto-Escuela;Kathleen Van Craenenbroeck;Wilber Romero-Fernandez;Diego Guidolin

  • Moonlighting Proteins and Protein–Protein Interactions as Neurotherapeutic Targets in the G Protein-Coupled Receptor Field

    Kjell Fuxe;Dasiel O Borroto-Escuela;Wilber Romero-Fernandez;Miklós Palkovits

  • Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and the transmembrane helices.

    Dasiel O. Borroto-Escuela;Wilber Romero-Fernandez;Alexander O. Tarakanov;Maricel Gómez-Soler

  • GPCR heteromers and their allosteric receptor-receptor interactions.

    K. Fuxe;D. O. Borroto-Escuela;D. Marcellino;W. Romero-Fernandez

  • Bioluminescence resonance energy transfer methods to study G protein-coupled receptor-receptor tyrosine kinase heteroreceptor complexes.

    Dasiel O. Borroto-Escuela;Marc Flajolet;Luigi F. Agnati;Paul Greengard

  • Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization.

    Dasiel O. Borroto-Escuela;Manuel Narvaez;Daniel Marcellino;Concepción Parrado

  • Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes

    Dasiel O. Borroto-Escuela;Wilber Romero-Fernandez;Manuel Narvaez;Julia Oflijan

  • The changing world of G protein-coupled receptors: from monomers to dimers and receptor mosaics with allosteric receptor-receptor interactions

    Kjell Fuxe;Daniel Marcellino;Dasiel Oscar Borroto-Escuela;Malgorzata Frankowska

  • Adenosine receptor containing oligomers: their role in the control of dopamine and glutamate neurotransmission in the brain.

    Francisco Ciruela;Maricel Gómez-Soler;Diego Guidolin;Dasiel O. Borroto-Escuela

  • The Role of Central Serotonin Neurons and 5-HT Heteroreceptor Complexes in the Pathophysiology of Depression: A Historical Perspective and Future Prospects

    Dasiel O. Borroto-Escuela;Dasiel O. Borroto-Escuela;Patrizia Ambrogini;Barbara Chruścicka;Barbara Chruścicka;Maria Lindskog

  • Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes.

    Dasiel O. Borroto-Escuela;Karolina Wydra;Julia Pintsuk;Manuel Narvaez

Frequent Co-Authors

Kjell Fuxe
Kjell Fuxe Karolinska Institute
Luigi F. Agnati
Luigi F. Agnati University of Modena and Reggio Emilia
Francisco Ciruela
Francisco Ciruela University of Barcelona
Luca Ferraro
Luca Ferraro University of Ferrara
Sergio Tanganelli
Sergio Tanganelli University of Ferrara
Gemma Navarro
Gemma Navarro University of Barcelona
Diego Guidolin
Diego Guidolin University of Padua
Giuseppa Mudò
Giuseppa Mudò University of Palermo
Natale Belluardo
Natale Belluardo University of Palermo
Miklós Palkovits
Miklós Palkovits Semmelweis University

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