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D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
20287
World Ranking
6248
National Ranking
118

Overview

Didier Picard is affiliated with the University of Geneva in Switzerland. Their research primarily falls within the broad field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Materials Chemistry, Aging, Genetics, and Spectroscopy.

The main topics explored in their work involve heat shock proteins research, enzyme structure and function, protein structure and dynamics, genetics, aging, and longevity in model organisms, estrogen and related hormone effects, CRISPR and genetic engineering, and viral infectious diseases and gene expression in insects.

Picard has contributed to numerous publications, including papers in influential peer-reviewed journals. Some notable recent papers include:

  • The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation, 2020, Nature Communications
  • Implementation of liquid chromatography-high resolution mass spectrometry methods for untargeted metabolomic analyses of biological samples: A tutorial, 2020, Analytica Chimica Acta
  • Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy, 2020, Cell Reports
  • The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis, 2020, BMC Biology
  • Cytosolic Hsp90 Isoform-Specific Functions and Clinical Significance, 2022, Biomolecules

Frequent coauthors working alongside Picard include Kaushik Bhattacharya, Dina Hany, Lilia Bernasconi, Diana Wider, and Samarpan Maiti.

Their research findings have been published in a variety of scientific venues with multiple contributions in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • eLife
  • Biomolecules
  • Cellular and Molecular Life Sciences

In addition to research articles, Picard has authored a book titled Heat Shock Proteins of Malaria, published by Springer Nature in 2021.

Best Publications

  • Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

    Giuseppe Bunone;Pierre André Briand;Richard J. Miksicek;Didier Picard

  • Reduced levels of hsp90 compromise steroid receptor action in vivo

    Didier Picard;Bushra Khursheed;Michael J. Garabedian;Marc G. Fortin;Marc G. Fortin

  • Heat-shock protein 90, a chaperone for folding and regulation.

    Didier Picard

  • Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

    M Eilers;D Picard;K R Yamamoto;J M Bishop

  • The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.

    Marcello Maggiolini;Adele Vivacqua;Giovanna Fasanella;Anna Grazia Recchia

  • The glucocorticoid responses are shaped by molecular chaperones.

    Iwona Grad;Didier Picard

  • The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo

    Daniel L. Riggs;Patricia J. Roberts;Samantha C. Chirillo;Joyce Cheung-Flynn

  • The unfolding stories of GPR30, a new membrane-bound estrogen receptor

    Marcello Maggiolini;Didier Picard

  • The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.

    Adele Vivacqua;Daniela Bonofiglio;Anna Grazia Recchia;Anna Maria Musti

  • RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase

    Olivier Donzé;Didier Picard

  • Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF

    Deo Prakash Pandey;Rosamaria Lappano;Lidia Albanito;Antonio Madeo

  • 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30.

    Adele Vivacqua;Daniela Bonofiglio;Lidia Albanito;Antonio Madeo

  • miR-22 Inhibits Estrogen Signaling by Directly Targeting the Estrogen Receptor α mRNA

    Deo Prakash Pandey;Didier Picard

  • Vectors for constitutive and inducible gene expression in yeast.

    Mark Schena;Didier Picard;Keith R. Yamamoto

  • Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells.

    Marcello Maggiolini;Daniela Bonofiglio;Stefania Marsico;Maria Luisa Panno

  • Fusion of GAL4-VP16 to a steroid-binding domain provides a tool for gratuitous induction of galactose-responsive genes in yeast.

    Jean-François Louvion;Biserka Havaux-Copf;Didier Picard

  • Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility

    Pablo Christian Echeverria;Didier Picard

  • An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine.

    Pablo Christian Echeverria;Andreas Bernthaler;Pierre Marcel Jean Dupuis;Bernd Mayer

  • Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

    Soichiro Yoshida;Shinji Tsutsumi;Guillaume Muhlebach;Carole Sourbier

  • Chaperoning steroid hormone action

    Didier Picard

Frequent Co-Authors

Marcello Maggiolini
Marcello Maggiolini University of Calabria
Sebastiano Andò
Sebastiano Andò University of Calabria
Leonard M. Neckers
Leonard M. Neckers National Institutes of Health
Jane B. Trepel
Jane B. Trepel National Institutes of Health
Serge Nef
Serge Nef University of Geneva
Pascal Mäser
Pascal Mäser Swiss Tropical and Public Health Institute
Katja Schenke-Layland
Katja Schenke-Layland University of Tübingen
Rejko Krüger
Rejko Krüger University of Luxembourg
Keith R. Yamamoto
Keith R. Yamamoto University of California, San Francisco
Nadia Naffakh
Nadia Naffakh Institut Pasteur

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