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D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
22370
World Ranking
15892
National Ranking
6600

Overview

Keisuke Kuida is a researcher affiliated with Takeda (United States) and has contributed extensively to the field of medicine, particularly within hematology, genetics, and molecular biology. Their work spans various subfields including hematology, genetics, molecular biology, reproductive medicine, and pulmonary and respiratory medicine.

The scientist has coauthored multiple research papers with frequent collaborators such as Haroun Achour, Filip Janků, Christina Chu, John L. Hays, and Rebecca C. Arend. Their publications have appeared primarily in prominent journals including the Journal of Clinical Oncology, Annals of Oncology, Leukemia, and Leukemia Research.

Key topics covered in Kuida's research include:

  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Chronic Myeloid Leukemia Treatments
  • Acute Myeloid Leukemia Research
  • Blood disorders and treatments
  • Kruppel-like factors research
  • Endometriosis Research and Treatment
  • Chronic Lymphocytic Leukemia Research

Notable recent papers authored or coauthored by Kuida are:

  • Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms, 2021, Leukemia
  • Open-label, multicenter, phase 1b/2 study of rebastinib in combination with paclitaxel to assess safety and efficacy in patients with advanced or metastatic endometrial cancer, 2021, Journal of Clinical Oncology
  • 558P A phase I study of rebastinib and carboplatin in patients with metastatic solid tumours, 2020, Annals of Oncology
  • Phase 1 first-in-human dose-expansion study of the oral SF3B1 modulator H3B-8800 in lower-risk myelodysplastic syndrome, 2025, Leukemia Research
  • 839P A phase Ib/II study of rebastinib and paclitaxel in advanced or metastatic platinum-resistant ovarian cancer, 2020, Annals of Oncology

The concentration of Kuida's work on hematological malignancies and targeted therapies reflects ongoing engagement with chronic and acute myeloid leukemia, as well as other blood-related disorders. The research also includes clinical trials involving drug combinations such as rebastinib with paclitaxel or carboplatin, relating to cancer treatments.

Best Publications

  • Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

    Keisuke Kuida;Timothy S. Zheng;Songqing Na;Chia-Yi Kuan

  • Reduced Apoptosis and Cytochrome c-Mediated Caspase Activation in Mice Lacking Caspase 9

    Keisuke Kuida;Tarik F Haydar;Chia-Yi Kuan;Yong Gu

  • Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

    Keisuke Kuida;Judith A. Lippke;George Ku;Matthew W. Harding

  • Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

    Yong Gu;Keisuke Kuida;Hiroko Tsutsui;George Ku

  • Caspases 3 and 7: key mediators of mitochondrial events of apoptosis.

    Saquib A. Lakhani;Ali Masud;Keisuke Kuida;George A. Porter

  • Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

    Vanessa S. Marsden;Liam O'Connor;Liam O'Connor;Lorraine A. O'Reilly;John Silke

  • Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis.

    Y E Chin;M Kitagawa;K Kuida;R A Flavell

  • The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.

    Dario S Zamboni;Koichi S Kobayashi;Koichi S Kobayashi;Tiana Kohlsdorf;Yasunori Ogura

  • Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury.

    Masato Koike;Masahiro Shibata;Masao Tadakoshi;Kunihito Gotoh

  • Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

    K Nakayama;I Negishi;K Kuida;H Sawa

  • Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice.

    Kei Ichi Nakayama;Keiko Nakayama;Izumi Negishi;Keisuke Kuida

  • Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation

    Takiko Hatai;Atsushi Matsuzawa;Seiji Inoshita;Yoshiyuki Mochida

  • Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation

    Yao Yao;Wei Li;Junwei Wu;Ursula A. Germann

  • Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation

    Dean A. Le;Yongqin Wu;Zhihong Huang;Kohji Matsushita

  • Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation.

    Timothy S. Zheng;Stéphane Hunot;Keisuke Kuida;Takashi Momoi

  • Bcl-2 Lies Downstream of Parathyroid Hormone–related Peptide in a Signaling Pathway That Regulates Chondrocyte Maturation during Skeletal Development

    Michael Amling;Lynn Neff;Sakae Tanaka;Daisuke Inoue

  • Caspase knockouts: matters of life and death.

    TS Zheng;S Hunot;K Kuida;RA Flavell

  • Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice.

    Hiroko Tsutsui;Nobuhiko Kayagaki;Keisuke Kuida;Hiroki Nakano

  • (S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18

    Woods Wannamaker;Robert Davies;Mark Namchuk;John Pollard

  • Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects.

    Christopher P. Regan;Wei Li;Diane M. Boucher;Stephen Spatz

Frequent Co-Authors

Richard A. Flavell
Richard A. Flavell Yale University
Masayuki Miyasaka
Masayuki Miyasaka Osaka University
Hajime Karasuyama
Hajime Karasuyama Tokyo Medical and Dental University
Hiroko Tsutsui
Hiroko Tsutsui Hyogo College of Medicine
Toshiyuki Tanaka
Toshiyuki Tanaka Hyogo University of Health Sciences
Kenji Nakanishi
Kenji Nakanishi Hyogo College of Medicine
Masayuki Miura
Masayuki Miura University of Tokyo
Shin Yonehara
Shin Yonehara Kyoto University
Yasuo Uchiyama
Yasuo Uchiyama Juntendo University
Pasko Rakic
Pasko Rakic Yale University

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