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Overview

Mechelle M. Lewis is affiliated with Penn State Milton S. Hershey Medical Center in the United States. Their research primarily focuses on the field of Medicine, with a strong emphasis on subfields such as Neurology, Cellular and Molecular Neuroscience, Cognitive Neuroscience, Radiology, Nuclear Medicine and Imaging, and Psychiatry and Mental Health.

Their work covers several central topics, including:

  • Parkinson's Disease Mechanisms and Treatments
  • Neurological disorders and treatments
  • Advanced Neuroimaging Techniques and Applications
  • Trace Elements in Health
  • Heavy Metal Exposure and Toxicity
  • Genetic Neurodegenerative Diseases
  • Cerebrospinal fluid and hydrocephalus

Mechelle M. Lewis has published extensively, with notable papers including:

  • "Tryptophan Metabolites Are Associated With Symptoms and Nigral Pathology in Parkinson's Disease" (2020) in Movement Disorders
  • "Decoupling of Global Brain Activity and Cerebrospinal Fluid Flow in Parkinson's Disease Cognitive Decline" (2021) in Movement Disorders
  • "Synergic control of action in levodopa-naïve Parkinson's disease patients: II. Multi-muscle synergies stabilizing vertical posture" (2020) in Experimental Brain Research
  • "Dynamics of Nigral Iron Accumulation in Parkinson's Disease: From Diagnosis to Late Stage" (2022) in Movement Disorders
  • "Multi-muscle synergies in preparation for gait initiation in Parkinson's disease" (2023) in Clinical Neurophysiology

Their frequent co-authors reflect sustained collaborations within the field and include Xuemei Huang, Lan Kong, Richard B. Mailman, Guangwei Du, and Paul J. Eslinger.

Mechelle M. Lewis has published in various venues, with multiple contributions to:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Movement Disorders
  • Journal of Parkinson's Disease
  • Parkinsonism & Related Disorders

The scope of their research involves both clinical and molecular approaches to neurological diseases, especially Parkinson's disease, addressing aspects from disease mechanisms to neuroimaging and toxicological impacts of trace elements.

Best Publications

  • Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes.

    Cindy P Lawler;Cassandra Prioleau;Mechelle M Lewis;Chun Mak

  • Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease

    Guangwei Du;Mechelle M. Lewis;Martin Styner;Michele L. Shaffer

  • Changes in multifinger interaction and coordination in Parkinson's disease

    Jaebum Park;Yen Hsun Wu;Mechelle M. Lewis;Xuemei Huang

  • Task specific influences of Parkinson’s disease on the striato-thalamo-cortical and cerebello-thalamo-cortical motor circuitries

    M.M. Lewis;C.G. Slagle;A.B. Smith;Y. Truong

  • Quantitative Susceptibility Mapping of the Midbrain in Parkinson’s Disease

    Guangwei Du;Tian Liu;Mechelle M. Lewis;Lan Kong

  • Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

    Souvarish Sarkar;Dharmin Rokad;Emir Malovic;Jie Luo

  • Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor-and akinetic/rigid-predominant Parkinson's disease

    Mechelle M. Lewis;Guangwei Du;Suman Sen;Suman Sen;Atsushi Kawaguchi

  • Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

    Dilshan S. Harischandra;Dharmin Rokad;Matthew L. Neal;Shivani Ghaisas

  • Functional Selectivity of Dopamine Receptor Agonists. I. Selective Activation of Postsynaptic Dopamine D2 Receptors Linked to Adenylate Cyclase

    David M. Mottola;Jason D. Kilts;Mechelle M. Lewis;Hilary S. Connery

  • Dynamic changes in cerebello-thalamo-cortical motor circuitry during progression of Parkinson's disease.

    Suman Sen;Atsushi Kawaguchi;Young Truong;Mechelle M. Lewis

  • Imaging nigral pathology and clinical progression in Parkinson's disease

    Guangwei Du;Mechelle M. Lewis;Suman Sen;Jianli Wang

  • Homologous Desensitization of the D1A Dopamine Receptor: Efficacy in Causing Desensitization Dissociates from Both Receptor Occupancy and Functional Potency

    Mechelle M. Lewis;Val J. Watts;Val J. Watts;Cindy P. Lawler;David E. Nichols

  • Functional Selectivity of Dopamine Receptor Agonists. II. Actions of Dihydrexidine in D2L Receptor-Transfected MN9D Cells and Pituitary Lactotrophs

    Jason D. Kilts;Hilary S. Connery;Elaine G. Arrington;Mechelle M. Lewis

  • Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study.

    Derek B Archer;Justin T Bricker;Winston T Chu;Roxana G Burciu

  • Tryptophan Metabolites Are Associated With Symptoms and Nigral Pathology in Parkinson's Disease.

    Patrick L. Heilman;Ernest W. Wang;Mechelle M. Lewis;Stanislaw Krzyzanowski

  • Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database

    Guodong Liu;Nicholas W. Sterling;Lan Kong;Mechelle M. Lewis

  • Effects of olivo-ponto-cerebellar atrophy (OPCA) on finger interaction and coordination

    Jaebum Park;Mechelle M. Lewis;Xuemei Huang;Mark L. Latash

  • Impaired synergic control of posture in Parkinson's patients without postural instability.

    Ali Falaki;Xuemei Huang;Mechelle M. Lewis;Mark L. Latash

  • Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders

    Sireesha Manne;Naveen Kondru;Monica Hepker;Huajun Jin

  • Shape (but not volume) changes in the thalami in Parkinson disease

    Martin J McKeown;Ashish Uthama;Rafeef Abugharbieh;Samantha Palmer

  • Sleep Disturbance Following Concussion Is a Risk Factor for a Prolonged Recovery.

    Harry Bramley;Alyssa Henson;Mechelle M. Lewis;Lan Kong

  • Higher iron in the red nucleus marks Parkinson's dyskinesia.

    Mechelle M. Lewis;Guangwei Du;Michal Kidacki;Nisargkumar Patel

  • Striatal shape in Parkinson's disease

    Nicholas W. Sterling;Guangwei Du;Mechelle M. Lewis;Christopher Dimaio

  • Free water improves detection of changes in the substantia nigra in parkinsonism: A multisite study

    Edward Ofori;Florian Krismer;Roxana G. Burciu;Ofer Pasternak

  • Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients

    Guangwei Du;Mechelle M. Lewis;Christopher Sica;Lu He

Frequent Co-Authors

Xuemei Huang
Xuemei Huang Pennsylvania State University
Richard B. Mailman
Richard B. Mailman Pennsylvania State University
Paul J. Eslinger
Paul J. Eslinger Penn State Milton S. Hershey Medical Center
Mark L. Latash
Mark L. Latash Pennsylvania State University
Martin J. McKeown
Martin J. McKeown University of British Columbia
Alexander I. Tröster
Alexander I. Tröster Barrow Neurological Institute
Sara R. Jones
Sara R. Jones Wake Forest University
Michael S. Okun
Michael S. Okun University of Florida
Ofer Pasternak
Ofer Pasternak Brigham and Women's Hospital
David E. Vaillancourt
David E. Vaillancourt University of Florida

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