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Biology and Biochemistry

D-Index
71
Citations
29739
World Ranking
6507
National Ranking
463

Overview

Manu Sharma is affiliated with the University of Tübingen in Germany. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with notable contributions in the subfields of Neurology, Molecular Biology, Genetics, Cellular and Molecular Neuroscience, and Immunology.

The scientist has contributed to research centered on several key topics including:

  • Parkinson's Disease Mechanisms and Treatments
  • RNA regulation and disease
  • Neurological diseases and metabolism
  • Genetic Associations and Epidemiology
  • Nuclear Receptors and Signaling
  • Neurological disorders and treatments
  • Lysosomal Storage Disorders Research

Manu Sharma's recent published papers include:

  • "Finding genetically-supported drug targets for Parkinson's disease using Mendelian randomization of the druggable genome" (2021, Nature Communications)
  • "Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets" (2021, JAMA Neurology)
  • "Genome-wide Association Analysis of Parkinson's Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci" (2020, Biological Psychiatry)
  • "RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses" (2024, The Lancet Neurology)
  • "Fine mapping of the HLA locus in Parkinson's disease in Europeans" (2021, npj Parkinson s Disease)

The scientist has frequently collaborated with other researchers, including:

  • Thomas Gasser
  • Ashwin Ashok Kumar Sreelatha
  • Rejko Krüger
  • Alexis Brice
  • Andrew Singleton

Manu Sharma publishes regularly in several scientific venues with repeated contributions in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Movement Disorders
  • npj Parkinson s Disease
  • Annals of Neurology
  • Zenodo (CERN European Organization for Nuclear Research)

Best Publications

  • Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

    Ellen Sidransky;Michael A. Nalls;Jan O. Aasly;Judith Aharon-Peretz

  • Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

    Mike A Nalls;Cornelis Blauwendraat;Costanza L Vallerga;Karl Heilbron

  • Genome-wide association study reveals genetic risk underlying Parkinson's disease

    Javier Simón-Sánchez;Claudia Schulte;Jose M Bras;Jose M Bras;Manu Sharma

  • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

    Mike A Nalls;Nathan Pankratz;Christina M. Lill;Chuong B. Do

  • α-Synuclein promotes SNARE-complex assembly in vivo and in vitro

    Jacqueline Burre;Manu Sharma;Theodoros Tsetsenis;Vladimir L. Buchman

  • Analysis of shared heritability in common disorders of the brain

    Verneri Anttila;Verneri Anttila;Brendan Bulik-Sullivan;Brendan Bulik-Sullivan;Hilary K. Finucane;Raymond K. Walters;Raymond K. Walters

  • Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study.

    Rachael A Evans;Hamish McAuley;Ewen M Harrison;Aarti Shikotra

  • Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: the PDGene database.

    Christina M. Lill;Johannes T. Roehr;Johannes T. Roehr;Matthew B. McQueen;Fotini K. Kavvoura;Fotini K. Kavvoura;Fotini K. Kavvoura

  • α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

    Jacqueline Burré;Manu Sharma;Thomas C. Südhof

  • Cell Biology and Pathophysiology of α-Synuclein.

    Jacqueline Burré;Manu Sharma;Thomas C. Südhof

  • Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy.

    Suzanne Lesage;Valérie Drouet;Elisa Majounie;Vincent Deramecourt

  • The ΔF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR

    Kai Du;Manu Sharma;Gergely L Lukacs

  • Misfolding diverts CFTR from recycling to degradation quality control at early endosomes

    Manu Sharma;Francesca Pampinella;Csilla Nemes;Mohamed Benharouga

  • Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function.

    Mark Etherton;Csaba Földy;Manu Sharma;Katsuhiko Tabuchi

  • Properties of native brain α-synuclein

    Jacqueline Burré;Sandro Vivona;Jiajie Diao;Manu Sharma

  • Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

    Jiajie Diao;Jacqueline Burré;Sandro Vivona;Daniel J Cipriano

  • Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.

    Owen A. Ross;Alexandra I. Soto-Ortolaza;Michael G. Heckman;Jan O. Aasly

  • Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.

    Cornelis Blauwendraat;Karl Heilbron;Costanza L. Vallerga;Sara Bandres-Ciga

  • SNCA Variants Are Associated with Increased Risk for Multiple System Atrophy

    Sonja W. Scholz;Sonja W. Scholz;Henry Houlden;Claudia Schulte;Manu Sharma

  • CASK Functions as a Mg2+-Independent Neurexin Kinase

    Konark Mukherjee;Manu Sharma;Henning Urlaub;Gleb P. Bourenkov

Frequent Co-Authors

Thomas Gasser
Thomas Gasser University of Tübingen
Alexis Brice
Alexis Brice Institut du Cerveau
Peter Heutink
Peter Heutink German Center for Neurodegenerative Diseases
Rejko Krüger
Rejko Krüger University of Luxembourg
Andrew B. Singleton
Andrew B. Singleton National Institutes of Health
Nicholas W. Wood
Nicholas W. Wood University College London
John Hardy
John Hardy University College London
Dena G. Hernandez
Dena G. Hernandez National Institutes of Health
Thomas C. Südhof
Thomas C. Südhof Stanford University
J. Raphael Gibbs
J. Raphael Gibbs National Institutes of Health

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