World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
62
Citations
13694
World Ranking
8820
National Ranking
2521

Overview

James D. Lear is affiliated with the University of Pennsylvania in the United States. Their research contributions span the fields of Biochemistry, Genetics and Molecular Biology as well as Neuroscience. Within these broader fields, they have focused on subfields including Cell Biology and Cellular and Molecular Neuroscience.

Their scientific work centers primarily on topics related to microtubule and mitosis dynamics, cellular transport and secretion, and photoreceptor and optogenetics research.

James D. Lear has published in the following venues:

  • PLoS ONE

One recent publication by Lear is titled "Correction: Dynein and Dynactin Leverage Their Bivalent Character to Form a High-Affinity Interaction," published in 2024 in PLoS ONE.

Collaborations feature a range of frequent co-authors, including:

  • Amanda E. Siglin
  • Shangjin Sun
  • Jeffrey K. Moore
  • Sarah Tan
  • Martin Poenie

Best Publications

  • Synthetic amphiphilic peptide models for protein ion channels

    JD Lear;ZR Wasserman;WF DeGrado

  • Protein design, a minimalist approach

    William F. DeGrado;Zelda R. Wasserman;James D. Lear

  • Design and synthesis of multi-haem proteins

    D E Robertson;R S Farid;C C Moser;J L Urbauer

  • A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity.

    Lawrence H. Pinto;Gregg R. Dieckmann;Chris S. Gandhi;Carol G. Papworth

  • Induction of peptide conformation at apolar water interfaces. 1. A study with model peptides of defined hydrophobic periodicity

    W. F. DeGrado;J. D. Lear

  • Asparagine-mediated self-association of a model transmembrane helix

    Christin Choma;Christin Choma;Holly Gratkowski;James D. Lear;William F. DeGrado

  • Polar side chains drive the association of model transmembrane peptides.

    Holly Gratkowski;James D. Lear;William F. DeGrado

  • Activation of Integrin αIIbß3 by Modulation of Transmembrane Helix Associations

    Renhao Li;Neal Mitra;Holly Gratkowski;Gaston Vilaire

  • Helical beta-peptide inhibitors of the p53-hDM2 interaction.

    Joshua A. Kritzer;James D. Lear;Michael E. Hodsdon;Alanna Schepartz

  • Membrane binding and conformational properties of peptides representing the NH2 terminus of influenza HA-2.

    J D Lear;W F DeGrado

  • Design of a heme-binding four-helix bundle

    Christin T. Choma;James D. Lear;Mark J. Nelson;P. Leslie Dutton

  • Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization.

    Michael W. Pantoliano;Robert A. Horlick;Barry A. Springer;Drew E. Van Dyk

  • Computational design of peptides that target transmembrane helices.

    Hang Yin;Joanna S. Slusky;Bryan W. Berger;Robin S. Walters

  • Phospholipid interactions of synthetic peptides representing the N-terminus of HIV gp41.

    Rafalski M;Lear Jd;DeGrado Wf

  • Synthetic peptides as models for ion channel proteins

    Karin S. Akerfeldt;Jim D. Lear;Zelda R. Wasserman;Laura A. Chung

  • Total Chemical Synthesis of the Integral Membrane Protein Influenza A Virus M2: Role of Its C-Terminal Domain in Tetramer Assembly†

    Gerd G. Kochendoerfer;David Salom;James D. Lear;Rosemarie Wilk-Orescan

  • How do helix–helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles

    William F. DeGrado;Holly Gratkowski;James D. Lear

  • Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains.

    Renhao Li;Charles R. Babu;James D. Lear;A. Joshua Wand

  • Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers

    Lidia Cristian;James D. Lear;William F. DeGrado

  • Tetraphilin : a four-helix proton channel built on a tetraphenylporphyrin framework

    Karin S. Akerfeldt;Ronald M. Kim;Daniel Camac;John T. Groves

Frequent Co-Authors

William F. DeGrado
William F. DeGrado University of California, San Francisco
Joel S. Bennett
Joel S. Bennett University of Pennsylvania
Robert A. Lamb
Robert A. Lamb Northwestern University
Lawrence H. Pinto
Lawrence H. Pinto Northwestern University
A. Joshua Wand
A. Joshua Wand University of Pennsylvania
Hang Yin
Hang Yin Tsinghua University
Peter N. Walsh
Peter N. Walsh Temple University
Michelle R. Arkin
Michelle R. Arkin University of California, San Francisco
Barry S. Cooperman
Barry S. Cooperman University of Pennsylvania
Andrew Pekosz
Andrew Pekosz Johns Hopkins University

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