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D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
20737
World Ranking
8502
National Ranking
150

Overview

Martin Irmler is affiliated with the University of Lausanne in Switzerland. Their research spans multiple domains within biomedical sciences, with a focus on molecular biology, physiology, immunology, pulmonary and respiratory medicine, and genetics. The scientist's work contributes notably to the fields of medicine and biochemistry, genetics, and molecular biology.

Irmler's recent publications highlight active investigation in cellular regeneration, metabolism, and pancreatic function. Significant papers include:

  • Inhibition of LTβR signalling activates WNT-induced regeneration in lung (2020, Nature)
  • Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice (2021, Nature Metabolism)
  • Generation of pancreatic β cells from CD177+ anterior definitive endoderm (2020, Nature Biotechnology)
  • Epithelial cell plasticity drives endoderm formation during gastrulation (2021, Nature Cell Biology)
  • Inceptor counteracts insulin signalling in β-cells to control glycaemia (2021, Nature)

The research topics that Irmler covers reflect a diverse interest in metabolic processes and immune function, with particular attention to the following:

  • Adipose Tissue and Metabolism
  • Metabolism, Diabetes, and Cancer
  • Pancreatic function and diabetes
  • Diet and metabolism studies
  • Air Quality and Health Impacts
  • T-cell and B-cell Immunology
  • Muscle metabolism and nutrition

Among the frequent coauthors collaborating with Irmler are Johannes Beckers, Martin Hrabé de Angelis, Andreas L. Birkenfeld, Cora Weigert, and Oliver Eickelberg. This collaboration indicates interdisciplinary work across various subfields of biology and medicine.

Irmler's publication record also includes numerous contributions to several prominent scientific journals and platforms. Notable venues where their work appears include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Nature Cell Biology
  • Molecular Metabolism
  • Cells

The scientist's subfields of interest emphasize the mechanisms underlying molecular biology processes, physiological responses, immune system function, respiratory health, and genetic factors. This multi-dimensional focus supports a comprehensive approach for understanding health and disease at molecular and cellular levels.

Best Publications

  • Inhibition of death receptor signals by cellular FLIP

    Martin Irmler;Margot Thome;Michael Hahne;Pascal Schneider

  • ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

    Sebastian Doll;Bettina Proneth;Yulia Y Tyurina;Elena Panzilius

  • Inhibition of Fas death signals by FLIPs

    Jürg Tschopp;Martin Irmler;Margot Thome

  • APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth

    Michael Hahne;Takao Kataoka;Michael Schröter;Kay Hofmann

  • The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways

    T. Kataoka;R.C. Budd;R.C. Budd;N. Holler;M. Thome

  • In Vivo Fate Mapping and Expression Analysis Reveals Molecular Hallmarks of Prospectively Isolated Adult Neural Stem Cells

    Ruth Beckervordersandforth;Pratibha Tripathi;Jovica Ninkovic;Efil Bayam

  • Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

    Sergio Gascón;Elisa Murenu;Giacomo Masserdotti;Felipe Ortega;Felipe Ortega;Felipe Ortega

  • Identification of proliferative and mature β-cells in the islets of Langerhans

    Erik Bader;Adriana Migliorini;Moritz Gegg;Noah Moruzzi

  • FLIP Prevents Apoptosis Induced by Death Receptors But Not by Perforin/Granzyme B, Chemotherapeutic Drugs, and Gamma Irradiation

    Takao Kataoka;Michael Schröter;Michael Hahne;Pascal Schneider

  • Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

    R. Sadoul;P. A. Fernandez;A. L. Quiquerez;I. Martinou

  • Targeted estrogen delivery reverses the metabolic syndrome

    Brian Finan;Bin Yang;Nickki Ottaway;Kerstin Stemmer

  • Trnp1 Regulates Expansion and Folding of the Mammalian Cerebral Cortex by Control of Radial Glial Fate

    Ronny Stahl;Ronny Stahl;Tessa Walcher;Camino De Juan Romero;Gregor Alexander Pilz

  • Activated B cells express functional Fas ligand

    Michael Hahne;Toufic Renno;Michael Schroeter;Martin Irmler

  • Granzyme A is an interleukin 1 beta-converting enzyme.

    M Irmler;S Hertig;H R MacDonald;R Sadoul

  • The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.

    Christoph Borner;Isabelle Martinou;Chantal Mattmann;Martin Irmler

  • Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and Genome-wide expression analysis

    Magdalena Götz;Swetlana Sirko;Johannes Beckers;Martin Irmler

  • The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network

    Jovica Ninkovic;Andrea Steiner-Mezzadri;Melanie Jawerka;Umut Akinci

  • Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

    Giacomo Masserdotti;Sébastien Gillotin;Sébastien Gillotin;Bernd Sutor;Daniela Drechsel

  • Stem-Cell-like Properties and Epithelial Plasticity Arise as Stable Traits after Transient Twist1 Activation

    Johanna M. Schmidt;Elena Panzilius;Harald S. Bartsch;Martin Irmler

  • Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance.

    Elisa Álvarez Hernández;Sabine Kahl;Anett Seelig;Paul Begovatz

Frequent Co-Authors

Johannes Beckers
Johannes Beckers Technical University of Munich
Oliver Eickelberg
Oliver Eickelberg University of Pittsburgh
Magdalena Götz
Magdalena Götz Ludwig-Maximilians-Universität München
Martin Hrabé de Angelis
Martin Hrabé de Angelis Technical University of Munich
Jürg Tschopp
Jürg Tschopp University of Lausanne
Hans-Ulrich Häring
Hans-Ulrich Häring University of Tübingen
Fabian J. Theis
Fabian J. Theis Technical University of Munich
Michael Hahne
Michael Hahne Centre national de la recherche scientifique, CNRS
Wolfgang Wurst
Wolfgang Wurst German Center for Neurodegenerative Diseases
Helmut Fuchs
Helmut Fuchs Helmholtz Zentrum München

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