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Chemistry

D-Index
58
Citations
13511
World Ranking
10527
National Ranking
2908

Overview

Kenneth L. Kirk is affiliated with the National Institutes of Health in the United States. Their research spans several interconnected fields, including Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Within these disciplines, key subfields of their work include Parasitology, Infectious Diseases, Virology, Molecular Biology, and Public Health, Environmental and Occupational Health.

They have contributed to a range of topics, particularly focused on infectious agents and disease treatment strategies. Main topics of their work include:

  • Toxoplasma gondii Research Studies
  • HIV/AIDS Drug Development and Treatment
  • HIV Research and Treatment
  • Polyamine Metabolism and Applications
  • Malaria Research and Control
  • Pneumocystis jirovecii Pneumonia Detection and Treatment
  • Computational Drug Discovery Methods

Their peer-reviewed publications have appeared in frequent venues such as PLoS Pathogens, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Scientific Reports, and the Journal of Medicinal Chemistry.

Selected recent publications include:

  • "A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin" (2022, Nature Communications)
  • "Identifying the major lactate transporter of Toxoplasma gondii tachyzoites" (2021, Scientific Reports)
  • "Substrate-mediated regulation of the arginine transporter of Toxoplasma gondii" (2021, PLoS Pathogens)
  • "An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials" (2021, Journal of Medicinal Chemistry)
  • "Coordinated action of multiple transporters in the acquisition of essential cationic amino acids by the intracellular parasite Toxoplasma gondii" (2021, PLoS Pathogens)

Kirk has collaborated frequently with several researchers, including:

  • Giel G. van Dooren
  • Adele M. Lehane
  • Esther Rajendran
  • Birte Steinhöfel
  • Deyun Qiu

Their work involves detailed investigation of parasitic protozoa such as Toxoplasma gondii and Plasmodium falciparum, focusing on mechanisms of drug resistance, transporter regulation, and amino acid acquisition by parasites. They have also engaged in computational approaches to drug discovery alongside experimental validation in antimalarial compounds.

Best Publications

  • Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

    Kenneth L. Kirk

  • Fluorine in medicinal chemistry: Recent therapeutic applications of fluorinated small molecules

    Kenneth L. Kirk

  • Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.

    Qi Chen;Michael Graham Espey;Andrew Y. Sun;Chaya Pooput

  • Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.

    Qi Chen;Michael Graham Espey;Andrew Y. Sun;Je-Hyuk Lee

  • Simultaneous determination of 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, and homovanillic acid in cerebrospinal fluid with high-performance liquid chromatography using electrochemical detection

    Mika Scheinin;Wen-Ho Chang;Kenneth L. Kirk;Markku Linnoila

  • Accumulation of Vitamin C (Ascorbate) and Its Oxidized Metabolite Dehydroascorbic Acid Occurs by Separate Mechanisms

    Richard W. Welch;Yaohui Wang;Arthur Crossman;Jae B. Park

  • 6-Fluorocatecholamines as false adrenergic neurotransmitters.

    C C Chiueh;Z Zukowska-Grojec;K L Kirk;I J Kopin

  • Fluoronorepinephrines: specific agonists for the activation of alpha and beta adrenergic-sensitive cyclic AMP-generating systems in brain slices.

    J W Daly;W Padgett;Y Nimitkitpaisan;C R Creveling

  • Selective Fluorination in Drug Design and Development: An Overview of Biochemical Rationales

    Kenneth L Kirk

  • Positron emission tomographic imaging of cardiac sympathetic innervation and function.

    D S Goldstein;P C Chang;G Eisenhofer;R Miletich

  • Cyclic AMP-generating systems: regional differences in activation by adrenergic receptors in rat brain

    JW Daly;W Padgett;CR Creveling;D Cantacuzene

  • 3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells.

    Itschak Lamensdorf;Graeme Eisenhofer;Judith Harvey-White;Amotz Nechustan

  • Species differences in structure-activity relationships of adenosine agonists and xanthine antagonists at brain A1 adenosine receptors

    Dieter Ukena;Kenneth A. Jacobson;William L. Padgett;Cristina Ayala

  • Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors.

    Kenneth A. Jacobson;Kenneth L. Kirk;William L. Padgett;John W. Daly

  • [3H]xanthine amine congener of 1,3-dipropyl-8-phenylxanthine: an antagonist radioligand for adenosine receptors.

    Kenneth A. Jacobson;Dieter Ukena;Kenneth L. Kirk;John W. Daly

  • Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity.

    Hideko Nagasawa;Yoshihiro Uto;Hideyuki Sasaki;Natsuko Okamura

  • Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4-dihydroxyphenylacetaldehyde.

    I. Lamensdorf;G. Eisenhofer;J. Harvey-White;Y. Hayakawa

  • Identification of arsenic-binding proteins in human breast cancer cells

    Xinyan Zhang;Fan Yang;Joong-Youn Shim;Kenneth L. Kirk

  • Facile synthesis of 2-substituted imidazoles

    Kenneth L. Kirk

  • Enantioselective Fluorination Mediated by N-Fluoroammonium Salts of Cinchona Alkaloids: First Enantioselective Synthesis of BMS-204352 (MaxiPost)

    Norio Shibata;Takehisa Ishimaru;Emiko Suzuki;Kenneth L Kirk

Frequent Co-Authors

Kenneth A. Jacobson
Kenneth A. Jacobson National Institutes of Health
John W. Daly
John W. Daly National Institutes of Health
Irwin J. Kopin
Irwin J. Kopin National Institutes of Health
Norio Shibata
Norio Shibata Nagoya Institute of Technology
Markku Linnoila
Markku Linnoila University of Helsinki
David S. Goldstein
David S. Goldstein National Institutes of Health
David C. Klein
David C. Klein National Institutes of Health
Robert S. Phillips
Robert S. Phillips University of Georgia
Roland Fröhlich
Roland Fröhlich University of Münster

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