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Biology and Biochemistry

D-Index
63
Citations
12097
World Ranking
10383
National Ranking
4509

Overview

Héctor H. Valdivia is affiliated with the University of Wisconsin-Madison in the United States. Their research focuses predominantly on fields within medicine and biochemistry, genetics, and molecular biology. The scientist's work spans multiple subfields including cardiology and cardiovascular medicine, molecular biology, physiology, genetics, and oncology.

The main topics addressed in their research include:

  • Cardiac electrophysiology and arrhythmias
  • Ion channel regulation and function
  • Cardiovascular effects of exercise
  • Receptor mechanisms and signaling
  • Nicotinic acetylcholine receptors study
  • Adipose tissue and metabolism
  • Venomous animal envenomation and studies

Valdivia has published extensively in multiple academic venues, with a frequent presence in:

  • Biophysical Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Circulation Research
  • Journal of Molecular and Cellular Cardiology
  • Circulation

Their recent publications include:

  • "Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation" (2021), Circulation Research
  • "Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation" (2023), Science Advances
  • "Mechanisms of ryanodine receptor 2 dysfunction in heart failure" (2020), Nature Reviews Cardiology
  • "Sorcin promotes migration in cancer and regulates the EGF-dependent EGFR signaling pathways" (2023), Cellular and Molecular Life Sciences
  • "Tetrodotoxin-Sensitive Neuronal-Type Na + Channels: A Novel and Druggable Target for Prevention of Atrial Fibrillation" (2020), Journal of the American Heart Association

Frequent collaborators in their work include Carmen R. Valdivia, Francisco Alvarado, Wenxuan Cai, Filip Van Petegem, and Holly Dooge. These coauthors have published multiple papers alongside Héctor H. Valdivia, contributing to research on cardiac and molecular physiology topics.

Best Publications

  • Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure.

    A. M. Gómez;H. H. Valdivia;H. Cheng;Miriam R. Lederer

  • The brain ryanodine receptor: a caffeine-sensitive calcium release channel

    Peter S. McPhersonx;Young Kee Kim;Hector Valdivia;C. Michael Knudson

  • Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation

    H. H. Valdivia;J. H. Kaplan;G. C. R. Ellis-Davies;W. J. Lederer

  • Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: A molecular autopsy of 49 medical examiner/coroner's cases

    David J. Tester;Daniel B. Spoon;Hector H. Valdivia;Jonathan C. Makielski

  • Abnormal Ca2+ Release, but Normal Ryanodine Receptors, in Canine and Human Heart Failure

    Ming Tao Jiang;Andrew J. Lokuta;Emily F. Farrell;Matthew R. Wolff

  • Scorpion venom components that affect ion-channels function.

    V. Quintero-Hernández;J.M. Jiménez-Vargas;G.B. Gurrola;G.B. Gurrola;H.H.F. Valdivia

  • Luminal Ca2+ Controls Termination and Refractory Behavior of Ca2+-Induced Ca2+ Release in Cardiac Myocytes

    Dmitry Terentyev;Serge Viatchenko-Karpinski;Héctor H. Valdivia;Ariel L. Escobar

  • Nitroxyl Improves Cellular Heart Function by Directly Enhancing Cardiac Sarcoplasmic Reticulum Ca2+ Cycling

    Carlo G. Tocchetti;Wang Wang;Jeffrey P. Froehlich;Sabine Huke

  • Modulation of cardiac ryanodine receptors of swine and rabbit by a phosphorylation-dephosphorylation mechanism.

    A J Lokuta;T B Rogers;W J Lederer;H H Valdivia

  • The immunophilin FK506-binding protein modulates Ca2+ release channel closure in rat heart.

    Rui Ping Xiao;Hector H. Valdivia;Konstantin Bogdanov;Carmen Valdivia

  • Depletion of T-tubules and specific subcellular changes in sarcolemmal proteins in tachycardia-induced heart failure

    Ravi C. Balijepalli;Andrew J. Lokuta;Nathan A. Maertz;Jennifer M. Buck

  • Modulation of Cardiac Ryanodine Receptors by Sorcin

    Andrew J. Lokuta;Marian B. Meyers;Paul R. Sander;Glenn I. Fishman

  • Scorpion toxins targeted against the sarcoplasmic reticulum Ca(2+)-release channel of skeletal and cardiac muscle

    H H Valdivia;M S Kirby;W J Lederer;R Coronado

  • Increased Nitration of Sarcoplasmic Reticulum Ca2+-ATPase in Human Heart Failure

    Andrew J. Lokuta;Nathan A. Maertz;Sivan Vadakkadath Meethal;Katherine T. Potter

  • Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm

    Marina Cerrone;Jerome Montnach;Xianming Lin;Yan Ting Zhao

  • Sorcin inhibits calcium release and modulates excitation-contraction coupling in the heart.

    Emily F. Farrell;Anaid Antaramian;Angelica Rueda;Ana M. Gómez

  • Intact β-Adrenergic Response and Unmodified Progression Toward Heart Failure in Mice With Genetic Ablation of a Major Protein Kinase A Phosphorylation Site in the Cardiac Ryanodine Receptor

    Nancy A. Benkusky;Craig S. Weber;Joseph A. Scherman;Emily F. Farrell

  • The Mechanism of Inhibition of Ryanodine Receptor Channels by Imperatoxin I, a Heterodimeric Protein from the Scorpion Pandinus imperator

    Fernando Z. Zamudio;Renaud Conde;Carolina Arévalo;Baltazar Becerril

  • Hyperphosphorylation of the Cardiac Ryanodine Receptor at Serine 2808 Is Not Involved in Cardiac Dysfunction After Myocardial Infarction

    Hongyu Zhang;Catherine A. Makarewich;Hajime Kubo;Wei Wang

  • Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis.

    Jinhua Shen;Wen Mei Yu;Marco Brotto;Joseph A. Scherman

Frequent Co-Authors

Lourival D. Possani
Lourival D. Possani National Autonomous University of Mexico
Richard L. Moss
Richard L. Moss University of Wisconsin–Madison
José Jalife
José Jalife University of Michigan–Ann Arbor
Timothy J. Kamp
Timothy J. Kamp University of Wisconsin–Madison
W. J. Lederer
W. J. Lederer University of Maryland, Baltimore
Heping Cheng
Heping Cheng Peking University
Donald M. Bers
Donald M. Bers University of California, Davis
Xander H.T. Wehrens
Xander H.T. Wehrens Baylor College of Medicine
Clara Franzini-Armstrong
Clara Franzini-Armstrong University of Pennsylvania

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