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Stephane Angers

Stephane Angers

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
21656
World Ranking
10002
National Ranking
341

Overview

Stephane Angers is affiliated with the University of Toronto in Canada. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with a total of 140 publications. Within these broad fields, their subfields of study include molecular biology, oncology, cell biology, genetics, and neurology.

Angers has contributed extensively to key research topics such as RNA research and splicing, Wnt/β-catenin signaling in development and cancer, cancer-related gene regulation, RNA modifications and cancer, glioma diagnosis and treatment, microtubule and mitosis dynamics, and ubiquitin and proteasome pathways.

Their body of work includes publications in several high-impact venues. Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory) with 18 publications, Cell Reports and Science Advances with 4 publications each, Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature with 4 publications, and Nature Communications with 3 publications.

Notable recent papers authored or co-authored by Angers consist of:

  • Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer, 2020, Nature Communications
  • Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity, 2021, Nature Cancer
  • Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma, 2020, Cell
  • Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival, 2021, eLife
  • Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b, 2022, Cell Reports Medicine

Frequent collaborators in their research include Graham MacLeod, Sichun Lin, Shana O. Kelley, Peter B. Dirks, and Sachdev S. Sidhu, reflecting collaborative efforts spanning various projects in their domains of expertise.

Best Publications

  • High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

    Traver Hart;Megha Chandrashekhar;Michael Aregger;Zachary Steinhart

  • Proximal events in Wnt signal transduction

    Stephane Angers;Randall T. Moon

  • Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET).

    Stephane Angers;Ali Salahpour;Eric Joly;Sandrine Hilairet

  • Gli Proteins in Development and Disease

    Chi-chung Hui;Stephane Angers

  • Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function.

    Stephane Angers;Ali Salahpour;Michel Bouvier

  • Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

    Stephane Angers;Ti Li;Xianhua Yi;Michael J. MacCoss

  • High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies

    Ji-Young Youn;Wade H. Dunham;Seo Jung Hong;James D.R. Knight

  • Wnt signaling in development and tissue homeostasis.

    Zachary Steinhart;Stephane Angers

  • Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

    Jean-Pierre Morello;Ali Salahpour;André Laperrière;Virginie Bernier

  • β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

    Mounia Azzi;Pascale G. Charest;Stéphane Angers;Guy Rousseau

  • Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer

    Jean-François Mercier;Ali Salahpour;Stéphane Angers;Andreas Breit

  • Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

    Henner F Farin;Ingrid Jordens;Mohammed H Mosa;Mohammed H Mosa;Onur Basak

  • Wilms Tumor Suppressor WTX Negatively Regulates WNT/β-Catenin Signaling

    Michael B. Major;Nathan D. Camp;Jason D. Berndt;Xianhua Yi

  • The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-β-catenin pathway by targeting Dishevelled for degradation

    Stephane Angers;Chris J. Thorpe;Travis L. Biechele;Seth J. Goldenberg

  • YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

    Africa Fernandez-L;Paul A. Northcott;James Dalton;Charles Fraga

  • CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

    Michal Zimmermann;Olga Murina;Martin A. M. Reijns;Angelo Agathanggelou

  • MONITORING OF LIGAND-INDEPENDENT DIMERIZATION AND LIGAND- INDUCED CONFORMATIONAL CHANGES OF MELATONIN RECEPTORS IN LIVING CELLS BY BIOLUMINESCENCE RESONANCE ENERGY TRANSFER

    Mohammed A. Ayoub;Cyril Couturier;Estelle Lucas-Meunier;Stephane Angers

  • Glutamate Transporter Coupling to Na,K-ATPase

    Erin M. Rose;Joseph C. P. Koo;Jordan E. Antflick;Syed M. Ahmed

  • Homodimerization of the β2-Adrenergic Receptor as a Prerequisite for Cell Surface Targeting *

    Ali Salahpour;Stéphane Angers;Jean-François Mercier;Monique Lagacé

  • Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

    Zachary Steinhart;Zvezdan Pavlovic;Megha Chandrashekhar;Traver Hart

Frequent Co-Authors

Jason Moffat
Jason Moffat University of Toronto
Sachdev S. Sidhu
Sachdev S. Sidhu University of Waterloo
Peter B. Dirks
Peter B. Dirks University of Toronto
Michel Bouvier
Michel Bouvier University of Montreal
Mathieu Lupien
Mathieu Lupien Princess Margaret Cancer Centre
Daniel Durocher
Daniel Durocher Lunenfeld-Tanenbaum Research Institute
Michael D. Taylor
Michael D. Taylor University of Toronto
Samuel Weiss
Samuel Weiss University of Calgary
Randall T. Moon
Randall T. Moon University of Washington
Stefano Marullo
Stefano Marullo Université Paris Cité

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