World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
95
Citations
27792
World Ranking
915
National Ranking
504

Medicine

D-Index
95
Citations
27757
World Ranking
10189
National Ranking
5237

Overview

What is he best known for?

The fields of study he is best known for:

  • Cancer
  • Gene
  • Virus

Tzyy Choou Wu mainly focuses on Antigen, Virology, DNA vaccination, CD8 and Immunology. His studies in Antigen integrate themes in fields like Vaccinia, Immune system, Antigen presentation and Cancer research. The various areas that he examines in his Virology study include Antigen Gene, Replicon and Vaccine Potency.

His study looks at the relationship between DNA vaccination and topics such as Potency, which overlap with Recombinant DNA. His studies deal with areas such as Molecular biology and Immunotherapy, Cancer immunotherapy as well as CD8. He has included themes like Lesion, Cervical intraepithelial neoplasia, In vivo and Confidence interval in his Immunology study.

His most cited work include:

  • Treatment of Established Tumors with a Novel Vaccine That Enhances Major Histocompatibility Class II Presentation of Tumor Antigen (889 citations)
  • Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. (390 citations)
  • Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene. (351 citations)

What are the main themes of his work throughout his whole career to date?

Immune system, Immunology, Antigen, DNA vaccination and Virology are his primary areas of study. His Immune system study combines topics from a wide range of disciplines, such as Cytotoxic T cell and Cancer research. His study in Immunology is interdisciplinary in nature, drawing from both Cervical cancer and HPV vaccines.

His Antigen research integrates issues from Molecular biology, Naked DNA and Antigen presentation. His DNA vaccination research includes elements of Genetic enhancement, Transfection and Immunogenicity. His Virology research is multidisciplinary, incorporating elements of Vaccinia and Replicon.

He most often published in these fields:

  • Immune system (36.49%)
  • Immunology (36.49%)
  • Antigen (32.88%)

What were the highlights of his more recent work (between 2014-2021)?

  • Cancer research (22.07%)
  • Immune system (36.49%)
  • DNA vaccination (30.18%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Cancer research, Immune system, DNA vaccination, Cancer and Immunology. His biological study spans a wide range of topics, including Cytotoxic T cell, Prospective cohort study, Biopsy and Antigen. His research in Antigen intersects with topics in Antibody, Combination therapy and Capsid.

His DNA vaccination research is multidisciplinary, incorporating elements of T cell, Calreticulin and Virology, Vaccination. His Cancer research includes elements of Oncology and Ascites. His Immunology research includes themes of HPV vaccines and Papillomavirus Vaccines.

Between 2014 and 2021, his most popular works were:

  • Perspectives for therapeutic HPV vaccine development (82 citations)
  • Immunotherapy for human papillomavirus-associated disease and cervical cancer: review of clinical and translational research (58 citations)
  • A pilot study of pNGVL4a-CRT/E7(detox) for the treatment of patients with HPV16 + cervical intraepithelial neoplasia 2/3 (CIN2/3) (58 citations)

In his most recent research, the most cited papers focused on:

  • Cancer
  • Gene
  • Virus

Tzyy Choou Wu mostly deals with Immunology, Cervical cancer, Cancer, Human papillomavirus and HPV vaccines. His Immunology research integrates issues from Pharmacology and In vivo. His research integrates issues of Radiation therapy, Chemotherapy, Reprogramming, Cytotoxic T cell and Epigenetics in his study of Cancer.

Tzyy Choou Wu combines subjects such as Virology, Hpv types, Therapeutic vaccine, DNA vaccination and Uterine cervix with his study of Human papillomavirus. His HPV vaccines study combines topics from a wide range of disciplines, such as Clinical trial, Cervix, Cervarix, Gardasil and Papillomavirus Vaccines. His Papillomavirus Vaccines research incorporates elements of Oncology, HPV infection and Vaccination.

Best Publications

  • Treatment of Established Tumors with a Novel Vaccine That Enhances Major Histocompatibility Class II Presentation of Tumor Antigen

    Ken Yu Lin;Frank G. Guarnieri;Kevin F. Staveley-O'Carroll;Hyam I. Levitsky

  • Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion.

    Kenneth D. Chavin;ShiQi Yang;Hui Zhi Lin;John Chatham

  • Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes.

    Christopher M. Heaphy;Andrea P. Subhawong;Seung Mo Hong;Michael G. Goggins

  • Prospects of RNA interference therapy for cancer.

    Pai Si;Lin Yy;Macaes B;Meneshian A

  • Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene.

    Chien Hung Chen;Tian Li Wang;Chien Fu Hung;Yanqin Yang

  • ENGINEERING AN INTRACELLULAR PATHWAY FOR MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II PRESENTATION OF ANTIGENS

    Tzyy-Choou Wu;F. G. Guarnieri;K. F. Staveley-O'carroll;R. P. Viscidi

  • Coronavirus vaccine development: from SARS and MERS to COVID-19.

    Yen Der Li;Wei Yu Chi;Jun Han Su;Louise Ferrall

  • How will HPV vaccines affect cervical cancer

    Richard Roden;T.-C. Wu

  • Cervical cancer immunotherapy: Facts and hopes

    Louise Ferrall;Ken Y. Lin;Richard B.S. Roden;Chien Fu Hung

  • Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen.

    Wen Fang Cheng;Chien Fu Hung;Chee Yin Chai;Keng Fu Hsu

  • Detection of EBV gene expression in Reed-Sternberg cells of Hodgkin's disease

    Tzyy Choou Wu;R. B. Mann;P. Charache;S. D. Hayward

  • Two Listeria monocytogenes Vaccine Vectors That Express Different Molecular Forms of Human Papilloma Virus-16 (HPV-16) E7 Induce Qualitatively Different T Cell Immunity That Correlates with Their Ability to Induce Regression of Established Tumors Immortalized by HPV-16

    George R. Gunn;Abba Zubair;Christian Peters;Zhen-Kun Pan

  • Spontaneous regression of high-grade cervical dysplasia: effects of human papillomavirus type and HLA phenotype.

    Cornelia L Trimble;Steven Piantadosi;Patti Gravitt;Brigitte Ronnett

  • Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis.

    Robert J. Kurman;Kala Visvanathan;Richard Roden;T. C. Wu

  • DNA vaccine for cancer immunotherapy

    Benjamin Yang;Jessica Jeang;Andrew Yang;T. C. Wu

  • Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver

    Asif Rashid;Tzyy Choou Wu;Chao Cheng Huang;Chien Hung Chen

  • The DCC gene product in cellular differentiation and colorectal tumorigenesis.

    Lora Hedrick;Kathleen R. Cho;Eric R. Fearon;Tzyy Choou Wu

  • Abundant expression of EBER1 small nuclear RNA in nasopharyngeal carcinoma. A morphologically distinctive target for detection of Epstein-Barr virus in formalin-fixed paraffin-embedded carcinoma specimens

    Tzyy-Choou Wu;R. B. Mann;J. I. Epstein;E. Macmahon

  • Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions.

    Leonel Maldonado;Jessica E. Teague;Matthew P. Morrow;Iveta Jotova

  • Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe

    Cornelia Trimble;Cheng Tao Lin;Cheng Tao Lin;Chien Fu Hung;Sara Pai

  • Therapeutic human papillomavirus vaccines: current clinical trials and future directions

    Chien Fu Hung;Barbara Ma;Archana Monie;Shaw Wei Tsen

  • Mycarditis and cardiotropic viral infection associated with severe left ventricular dysfunction in late-stage infection with human immunodeficiency virus

    Ahvie Herskowitz;Tzyy Choou Wu;Sharon B. Willoughby;David Vlahov

Frequent Co-Authors

Chien-Fu Hung
Chien-Fu Hung Johns Hopkins University
Richard B.S. Roden
Richard B.S. Roden Johns Hopkins University
Robert J. Kurman
Robert J. Kurman Johns Hopkins University
Ralph H. Hruban
Ralph H. Hruban Johns Hopkins University School of Medicine
Drew M. Pardoll
Drew M. Pardoll Johns Hopkins University School of Medicine
Ronald D. Alvarez
Ronald D. Alvarez Vanderbilt University Medical Center
Tian Li Wang
Tian Li Wang Johns Hopkins University
Raphael P. Viscidi
Raphael P. Viscidi Johns Hopkins University
Grover M. Hutchins
Grover M. Hutchins Johns Hopkins University
Patti E. Gravitt
Patti E. Gravitt National Institutes of Health

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