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Immunology

D-Index
47
Citations
11149
World Ranking
4485
National Ranking
178

Overview

Toos Daemen is affiliated with the University Medical Center Groningen in the Netherlands. Their research spans multiple fields, mainly focusing on Biochemistry, Genetics and Molecular Biology, with 33 publications, as well as Medicine, with 23 publications. Within these domains, Daemen's subfields of study include Molecular Biology, Genetics, Immunology, Epidemiology, and Oncology.

Their work centers around several key topics that have shaped Daemen's publication record. These topics are:

  • Virus-based gene therapy research
  • CAR-T cell therapy research
  • Immune cells in cancer
  • Cancer, Hypoxia, and Metabolism
  • RNA Interference and Gene Delivery
  • Viral Infectious Diseases and Gene Expression in Insects
  • Animal Virus Infections Studies

Daemen has contributed papers to a variety of scientific venues. The most frequent publication platforms include:

  • Vaccines
  • Scientific Reports
  • iScience
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Therapy

Among recent papers authored or co-authored by Daemen, the following are notable:

  • "First-in-Human Phase I Clinical Trial of an SFV-Based RNA Replicon Cancer Vaccine against HPV-Induced Cancers," 2020, Molecular Therapy
  • "Re-polarization of immunosuppressive macrophages to tumor-cytotoxic macrophages by repurposed metabolic drugs," 2021, OncoImmunology
  • "Resistance Mechanisms Influencing Oncolytic Virotherapy, a Systematic Analysis," 2021, Vaccines
  • "Therapeutic Vaccines and Cancer Immunotherapy," 2020, Vaccines
  • "Hepatitis C Virus Proteins Core and NS5A Are Highly Sensitive to Oxidative Stress-Induced Degradation after eIF2α/ATF4 Pathway Activation," 2020, Viruses

In their collaborations, Daemen frequently works with several co-authors, including:

  • Darshak Bhatt
  • Franz J. Weissing
  • Baukje Nynke Hoogeboom
  • Thijs Janzen
  • Annemarie Boerma

Best Publications

  • The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis

    Marloes Gooden;de Truuske Bock;Ninke Leffers;Toos Daemen

  • Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system

    Gert Storm;Sheila O. Belliot;Toos Daemen;Danilo D. Lasic

  • Liposomes in the Therapy of Infectious Disease and Cancer

    Toos Daemen;M Hardonk;J Koudstaal;W oosterhuis

  • Cells of the hepatic sinusoid

    Toos Daemen;J Koudstaal;GL Scherphof;M Hardonk

  • Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer.

    Ninke Leffers;Marloes J. M. Gooden;Renske A. de Jong;Baukje-Nynke Hoogeboom

  • A potential role of macrophage activation in the treatment of cancer.

    AH Klimp;de Elisabeth G. E. Vries;GL Scherphof;Toos Daemen

  • The virosome concept for influenza vaccines

    Anke Huckriede;Laura Bungener;Toon Stegmann;Toos Daemen

  • Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy

    Oana Draghiciu;Joyce Lubbers;Hans W Nijman;Toos Daemen

  • Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Human Ovarian Tumors and Tumor-associated Macrophages

    Alida H. Klimp;Harry Hollema;Claudia Kempinga;Ate G. J. van der Zee

  • Liposomal doxorubicin-induced toxicity: depletion and impairment of phagocytic activity of liver macrophages

    Toos Daemen;Gert Hofstede;Marian T. Ten Kate;Irma A. J. M. Bakker-Woudenberg

  • Immunization with a P53 synthetic long peptide vaccine induces P53‐specific immune responses in ovarian cancer patients, a phase II trial

    Ninke Leffers;Annechien J. A. Lambeck;Marloes J. M. Gooden;Baukje-Nynke Hoogeboom

  • Virosome-mediated delivery of protein antigens to dendritic cells.

    Laura Bungener;Karine Serre;Liesbeth Bijl;Lee Leserman

  • Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response

    Mariëtte I E van Poelgeest;Marij J P Welters;Renee Vermeij;Linda F M Stynenbosch

  • CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer.

    Fenne L. Komdeur;Thalina M. Prins;Stephanie van de Wall;Annechien Plat

  • Frequencies and role of regulatory T cells in patients with (pre)malignant cervical neoplasia.

    Jeroen Visser;Hans Nijman;B.-N. Hoogenboom;P. Jager

  • Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication

    Oana Draghiciu;Hans W Nijman;Baukje Nynke Hoogeboom;Tjarko Meijerhof

  • Virosomes for antigen and DNA delivery

    Toos Daemen;Arjan de Mare;Laura Bungener;Jørgen de Jonge

  • Serum Cytokine Profiling as a Diagnostic and Prognostic Tool in Ovarian Cancer: A Potential Role for Interleukin 7

    Annechien J. A. Lambeck;Anne P. G. Crijns;Ninke Leffers;Wim J. Sluiter

  • Induction of cytotoxic T lymphocyte activity by fusion-active peptide-containing virosomes.

    Annemarie Arkema;Anke Huckriede;Pieter Schoen;Jan Wilschut

  • Virosome-mediated delivery of protein antigens in vivo: efficient induction of class I MHC-restricted cytotoxic T lymphocyte activity

    Laura Bungener;Anke Huckriede;Arjan de Mare;Jacqueline de Vries-Idema

  • Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer: A single-arm phase II study

    Renee Vermeij;Ninke Leffers;Baukje-Nynke Hoogeboom;Ineke L. E. Hamming

Frequent Co-Authors

Jan Wilschut
Jan Wilschut University Medical Center Groningen
Gerrit L. Scherphof
Gerrit L. Scherphof University of Groningen
Harry Hollema
Harry Hollema University Medical Center Groningen
Anke Huckriede
Anke Huckriede University Medical Center Groningen
Maarten J. Postma
Maarten J. Postma University of Groningen
Cornelis J. M. Melief
Cornelis J. M. Melief ISA Pharmaceuticals (Netherlands)
Sjoerd H. van der Burg
Sjoerd H. van der Burg Leiden University Medical Center
Ed Schuuring
Ed Schuuring University Medical Center Groningen
Jan Kornelis Dijkstra
Jan Kornelis Dijkstra University of Groningen

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