World's Best Scientists 2026 revealed!

Overview

Igor Dmitriev is affiliated with Washington University in St. Louis in the United States. Their research spans multiple fields primarily within Medicine and Biochemistry, Genetics and Molecular Biology. Their work notably covers Infectious Diseases, Molecular Biology, Genetics, Immunology, and Epidemiology as key subfields.

The focus of their scientific contributions includes virus-based gene therapy research, SARS-CoV-2 and COVID-19 research, RNA interference and gene delivery, COVID-19 clinical research studies, viral gastroenteritis research and epidemiology, viral infectious diseases and gene expression in insects, and immunotherapy and immune responses.

Frequent coauthors who have collaborated with Dmitriev include David T. Curiel, Elena A. Kashentseva, Zhi Hong Lu, Michael Diamond, and Baoling Ying.

Their publications often appear in venues such as bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, Nature Immunology, Molecular Therapy, and Gastroenterology.

Selected recent papers highlight the scope and focus of their research:

  • A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2 (2020, Cell)
  • An intranasal vaccine durably protects against SARS-CoV-2 variants in mice (2021, Cell Reports)
  • Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection (2024, Nature Immunology)
  • Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB.1.16 infection in nonhuman primates (2024, Nature Immunology)
  • Efficient Genome Editing Achieved via Plug-and-Play Adenovirus Piggyback Transport of Cas9/gRNA Complex on Viral Capsid Surface (2022, ACS Nano)

Best Publications

  • An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism.

    Igor Dmitriev;Victor Krasnykh;C. Ryan Miller;Minghui Wang

  • A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.

    Ahmed O. Hassan;Natasha M. Kafai;Igor P. Dmitriev;Julie M. Fox

  • Characterization of an Adenovirus Vector Containing a Heterologous Peptide Epitope in the HI Loop of the Fiber Knob

    Victor Krasnykh;Igor Dmitriev;Galina Mikheeva;C. Ryan Miller

  • Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells.

    Igor Dmitriev;Elena Kashentseva;Buck E. Rogers;Victor Krasnykh

  • Targeting Mcl-1 for the therapy of cancer

    Bridget A Quinn;Rupesh Dash;Belal Azab;Siddik Sarkar

  • Engineering of Adenovirus Vectors Containing Heterologous Peptide Sequences in the C Terminus of Capsid Protein IX

    Igor P. Dmitriev;Elena A. Kashentseva;David T. Curiel

  • Treatment of ovarian cancer with a tropism modified oncolytic adenovirus.

    Gerd J. Bauerschmitz;John T. Lam;Anna Kanerva;Kaori Suzuki

  • Double modification of adenovirus fiber with RGD and polylysine motifs improves coxsackievirus-adenovirus receptor-independent gene transfer efficiency

    Hongju Wu;Toshiro Seki;Igor Dmitriev;Taco Uil

  • A system for the propagation of adenoviral vectors with genetically modified receptor specificities.

    Joanne T. Douglas;C. Ryan Miller;Myunghee Kim;Igor Dmitriev

  • Construction and Characterization of Adenovirus Serotype 5 Packaged by Serotype 3 Hexon

    Hongju Wu;Igor Dmitriev;Elena Kashentseva;Toshiro Seki

  • Adenoviral gene therapy for renal cancer requires retargeting to alternative cellular receptors.

    Yosef S. Haviv;Yosef S. Haviv;Jerry L. Blackwell;Jerry L. Blackwell;Anna Kanerva;Anna Kanerva;Peter Nagi;Peter Nagi

  • Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain.

    Elena A Kashentseva;Toshiro Seki;David T Curiel;Igor P Dmitriev

  • Improved gene transfer efficiency to primary and established human pancreatic carcinoma target cells via epidermal growth factor receptor and integrin-targeted adenoviral vectors

    J. G. Wesseling;P. J. Bosma;Victor Krasnykh;E. A. Kashentseva

  • Identification of Sites in Adenovirus Hexon for Foreign Peptide Incorporation

    Hongju Wu;Tie Han;Natalya Belousova;Victor Krasnykh

  • Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity

    Rupesh Dash;Belal Azab;Bridget A. Quinn;Xuening Shen

  • mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.

    Rupesh Dash;Sujit K. Bhutia;Belal Azab;Zhao zhong Su

  • mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review).

    Irina V. Lebedeva;Luni Emdad;Zao Zhong Su;Pankaj Gupta

  • Fluorescently labeled adenovirus with pIX-EGFP for vector detection.

    Long P. Le;Maaike Everts;Igor P. Dmitriev;Julia G. Davydova

  • An intranasal vaccine durably protects against SARS-CoV-2 variants in mice.

    Ahmed O. Hassan;Swathi Shrihari;Matthew J. Gorman;Baoling Ying

  • Targeting oncolytic adenoviral agents to the epidermal growth factor pathway with a secretory fusion molecule.

    Akseli Hemminki;Igor Dmitriev;Bin Liu;Renee A. Desmond

Frequent Co-Authors

David T. Curiel
David T. Curiel Washington University in St. Louis
Victor Krasnykh
Victor Krasnykh The University of Texas MD Anderson Cancer Center
Paul B. Fisher
Paul B. Fisher Virginia Commonwealth University
Paul Dent
Paul Dent Virginia Commonwealth University
Devanand Sarkar
Devanand Sarkar Virginia Commonwealth University
Steven Grant
Steven Grant Virginia Commonwealth University
Akseli Hemminki
Akseli Hemminki University of Helsinki
Adly Yacoub
Adly Yacoub Virginia Commonwealth University
John C. Reed
John C. Reed Johnson & Johnson (United States)
Sujit K. Bhutia
Sujit K. Bhutia National Institute of Technology Rourkela

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