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Biology and Biochemistry

D-Index
63
Citations
13254
World Ranking
10279
National Ranking
266

Overview

Rob C. Hoeben is affiliated with Leiden University Medical Center in the Netherlands. Their research activity spans multiple fields within the life sciences, with a primary focus on biochemistry, genetics, and molecular biology as well as medicine.

Their work explores several subfields, including:

  • Genetics
  • Molecular Biology
  • Oncology
  • Immunology
  • Infectious Diseases

Key topics covered in their research include:

  • Virus-based gene therapy research
  • CAR-T cell therapy research
  • Viral gastroenteritis research and epidemiology
  • Cancer Research and Treatments
  • CRISPR and Genetic Engineering
  • RNA Interference and Gene Delivery
  • Immune Cell Function and Interaction

Rob C. Hoeben has published extensively, with notable papers including:

  • Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components, 2020, Gene Therapy
  • Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy, 2020, Journal for ImmunoTherapy of Cancer
  • NanoBiT System and Hydrofurimazine for Optimized Detection of Viral Infection in Mice-A Novel in Vivo Imaging Platform, 2020, International Journal of Molecular Sciences
  • The stability of envelope-pseudotyped lentiviral vectors, 2020, Gene Therapy
  • Adenovirus Receptor Expression in Cancer and Its Multifaceted Role in Oncolytic Adenovirus Therapy, 2020, International Journal of Molecular Sciences

Their frequent collaborators include:

  • Diana J.M. van den Wollenberg
  • Gabri van der Pluijm
  • Selas T. F. Bots
  • Vera Kemp
  • Nadine van Montfoort

Rob C. Hoeben's publications often appear in specific journals, with multiple papers published in:

  • International Journal of Molecular Sciences
  • European Urology Open Science
  • Cancer Gene Therapy
  • Cancer Research
  • Gene Therapy

Best Publications

  • New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses.

    Frits J. Fallaux;Abraham Bout;Ietje van der Velde;Diana J. M. van den Wollenberg

  • Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors.

    Frits J. Fallaux;Onno Kranenburg;Steve J. Cramer;Ada Houweling

  • Packaging systems for human recombinant adenovirus to be used in gene therapy

    Frits Jacobus Fallaux;Robert Cornelis Hoeben;Alex Jan Van der Eb;Abraham Bout

  • Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle.

    M H Noteborn;G F de Boer;D J van Roozelaar;C Karreman

  • Induction of Atherosclerotic Plaque Rupture in Apolipoprotein E−/− Mice After Adenovirus-Mediated Transfer of p53

    Jan H. Von Der Thüsen;Bart J. M. Van Vlijmen;Rob C. Hoeben;Mark M. Kockx

  • Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development.

    Heleen Lie-Venema;Nynke M S van den Akker;Noortje A M Bax;Elizabeth M Winter

  • Highly efficient transduction of human monocyte-derived dendritic cells with subgroup B fiber-modified adenovirus vectors enhances transgene-encoded antigen presentation to cytotoxic T cells.

    Delphine Rea;Menzo J. E. Havenga;Maayke van den Assem;Roger P. M. Sutmuller

  • Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis

    Yoann Rombouts;Annemiek Willemze;Joyce J B C van Beers;Jing Shi

  • Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

    Maria J L Kracht;Menno van Lummel;Tatjana Nikolic;Antoinette M Joosten

  • Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity.

    Alexandra Chadt;Katja Leicht;Atul Deshmukh;Lake Q. Jiang

  • Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position.

    R. C. Hoeben;A. A. J. Migchielsen;R. C. M. Van Der Jagt;H. Van Ormondt

  • Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes.

    Françoise Carlotti;Merlijn Bazuine;Tuija Kekarainen;Jurgen Seppen

  • Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration.

    MM van der Eb;SJ Cramer;Y Vergouwe;Fhe Schagen

  • Adenoviruses Activate Human Dendritic Cells without Polarization toward a T-Helper Type 1-Inducing Subset

    Delphine Rea;Frederik H. E. Schagen;Rob C. Hoeben;Majid Mehtali

  • Specific tumor-cell killing with adenovirus vectors containing the apoptin gene

    A M Pietersen;M M van der Eb;H J Rademaker;D J M van den Wollenberg

  • The adenovirus capsid: major progress in minor proteins.

    Jort Vellinga;Stephanie Van der Heijdt;Rob C. Hoeben

  • p16INK4a Is Required for hSNF5 Chromatin Remodeler-induced Cellular Senescence in Malignant Rhabdoid Tumor Cells

    Igor Oruetxebarria;Francesca Venturini;Tuija Kekarainen;Ada Houweling

  • Conversion of mature human β-cells into glucagon-producing α-cells

    H. Siebe Spijker;Raimond B.G. Ravelli;A. Mieke Mommaas-Kienhuis;Aart A. van Apeldoorn

  • Protective anti-tumor immunity induced by vaccination with recombinant adenoviruses encoding multiple tumor-associated cytotoxic T lymphocyte epitopes in a string-of-beads fashion

    René E. M. Toes;Rob C. Hoeben;Ellen I. H. van der Voort;Maaike E. Ressing

  • Adenovirus DNA Replication

    Rob C. Hoeben;Taco G. Uil

Frequent Co-Authors

A. J. Van Der Eb
A. J. Van Der Eb Leiden University
Emmanuel J. H. J. Wiertz
Emmanuel J. H. J. Wiertz Utrecht University
René E. M. Toes
René E. M. Toes Leiden University Medical Center
Rob G. H. H. Nelissen
Rob G. H. H. Nelissen Leiden University Medical Center
Onno Kranenburg
Onno Kranenburg Utrecht University
Bart O. Roep
Bart O. Roep Leiden University Medical Center
Rienk Offringa
Rienk Offringa German Cancer Research Center
Frank J.T. Staal
Frank J.T. Staal Leiden University Medical Center
Joost Verhaagen
Joost Verhaagen Netherlands Institute for Neuroscience
Tom W. J. Huizinga
Tom W. J. Huizinga Leiden University Medical Center

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