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Biology and Biochemistry

D-Index
64
Citations
11305
World Ranking
9898
National Ranking
4334

Overview

R. Stephen Lloyd is affiliated with Oregon Health & Science University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions in agricultural and biological sciences.

Their work spans several subfields, including molecular biology, plant science, cancer research, genetics, and epidemiology. Key research topics include DNA repair mechanisms, mycotoxins in agriculture and food, carcinogens and genotoxicity assessment, plant pathogens and resistance, molecular biology techniques and applications, cancer therapeutics and mechanisms, and epigenetics and DNA methylation.

They have published extensively in scientific journals, with frequent contributions in venues such as DNA repair, Chemical Research in Toxicology, Environmental and Molecular Mutagenesis, PLoS ONE, and Proceedings of the National Academy of Sciences.

Frequent coauthors collaborating with R. Stephen Lloyd include:

  • Irina G. Minko
  • Amanda K. McCullough
  • Vladimir L. Vartanian
  • Paweł Jaruga
  • Miral Dizdaroğlu

Notable recent papers authored or coauthored by R. Stephen Lloyd include:

  • "OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model," 2020, published in PLoS ONE
  • "Enhanced cytarabine-induced killing in OGG1-deficient acute myeloid leukemia cells," 2021, published in Proceedings of the National Academy of Sciences
  • "DNA Sequence Modulates the Efficiency of NEIL1-Catalyzed Excision of the Aflatoxin B1-Induced Formamidopyrimidine Guanine Adduct," 2021, published in Chemical Research in Toxicology
  • "Complex Roles of NEIL1 and OGG1: Insights Gained from Murine Knockouts and Human Polymorphic Variants," 2022, published in DNA
  • "Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase," 2023, published in Nucleic Acids Research

Best Publications

  • MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily

    Yue Guan;Raymond C. Manuel;Andrew S. Arvai;Sudip S. Parikh

  • The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame.

    K E Hill;R S Lloyd;J G Yang;R Read

  • The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase

    Vladimir Vartanian;Brian Lowell;Irina G. Minko;Thomas G. Wood

  • Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA.

    K E Hill;R S Lloyd;R F Burk

  • Evidence for an Imino Intermediate in the DNA Polymerase β Deoxyribose Phosphate Excision Reaction

    Colleen E. Piersen;Rajendra Prasad;Samuel H. Wilson;R. Stephen Lloyd

  • Interstrand DNA Cross-links Induced by α,β-Unsaturated Aldehydes Derived from Lipid Peroxidation and Environmental Sources

    Michael P. Stone;Young-Jin Cho;Hai Huang;Hye-Young Kim

  • hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs

    Istvan Boldogh;Daun Milligan;Myung Soog Lee;Heather Bassett

  • 1,N 2-Deoxyguanosine Adducts of Acrolein, Crotonaldehyde, and trans-4-Hydroxynonenal Cross-link to Peptides via Schiff Base Linkage

    Andrew J. Kurtz;R. Stephen Lloyd

  • Studies on the Catalytic Mechanism of Five DNA Glycosylases PROBING FOR ENZYME-DNA IMINO INTERMEDIATES

    Bin Sun;Katherine A. Latham;M.L. Dodson;R. Stephen Lloyd

  • Chemistry and Biology of DNA Containing 1,N2-Deoxyguanosine Adducts of the α,β-Unsaturated Aldehydes Acrolein, Crotonaldehyde, and 4-Hydroxynonenal

    Irina G. Minko;Ivan D. Kozekov;Thomas M. Harris;Carmelo J. Rizzo

  • Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity.

    R W Bork;T Muto;P H Beaune;P K Srivastava

  • Role for DNA Polymerase κ in the Processing of N2-N2-Guanine Interstrand Cross-links

    Irina G. Minko;Michael B. Harbut;Ivan D. Kozekov;Albena Kozekova

  • Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.

    C. Ged;D. R. Umbenhauer;T. M. Bellew;R. W. Bork

  • Efficient and Error-Free Replication Past a Minor-Groove DNA Adduct by the Sequential Action of Human DNA Polymerases ι and κ

    M. Todd Washington;M. Todd Washington;Irina G. Minko;Robert E. Johnson;William T. Wolfle

  • 8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

    Harini Sampath;Vladimir Vartanian;M. Rick Rollins;Kunihiko Sakumi

  • Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli

    Tapas K. Hazra;James G. Muller;Raymond C. Manuel;Cynthia J. Burrows

  • AP lyases and dRPases : commonality of mechanism

    Colleen E Piersen;Amanda K McCullough;R.Stephen Lloyd

  • Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.

    Michael K. Chan;Maria T. Ocampo-Hafalla;Vladimir Vartanian;Pawel Jaruga;Pawel Jaruga

  • Incision of DNA–protein crosslinks by UvrABC nuclease suggests a potential repair pathway involving nucleotide excision repair

    Irina G. Minko;Yue Zou;R. Stephen Lloyd

  • Polymorphism of human cytochrome P-450

    F. P. Guengerich;D. R. Umbenhauer;P. F. Churchill;P. H. Beaune

Frequent Co-Authors

Thomas M. Harris
Thomas M. Harris Vanderbilt University
Pawel Jaruga
Pawel Jaruga National Institute of Standards and Technology
Miral Dizdaroglu
Miral Dizdaroglu National Institute of Standards and Technology
Satya Prakash
Satya Prakash The University of Texas Medical Branch at Galveston
Louise Prakash
Louise Prakash The University of Texas Medical Branch at Galveston
Martin Egli
Martin Egli Vanderbilt University
Anton Simeonov
Anton Simeonov National Institutes of Health
Thomas G. Wood
Thomas G. Wood The University of Texas Medical Branch at Galveston
Samuel H. Wilson
Samuel H. Wilson National Institutes of Health
Ajit Jadhav
Ajit Jadhav Pfizer (Germany)

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