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H G Khorana

H G Khorana

D-Index & Metrics

Biology and Biochemistry

D-Index
119
Citations
44448
World Ranking
681
National Ranking
430

Research.com Recognitions

  • 1987 - US President's National Medal of Science "For his innovative contributions that significantly contributed to our understanding of gene structure, membrane function and vision and for the work stimulated by his research which has had a major impact on the biological and chemical sciences.", Presented by President Reagan at a White House Ceremony on June 25, 1987.
  • 1968 - Nobel Prize for their interpretation of the genetic code and its function in protein synthesis
  • 1966 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1966 - Member of the National Academy of Sciences

Overview

H G Khorana was a scientist affiliated with the Massachusetts Institute of Technology (MIT) in the United States. Their research spanned significant areas related to gene structure, membrane function, and vision, contributing to advances in biological and chemical sciences.

Khorana received multiple prestigious recognitions throughout their career. In 1968, they were awarded the Nobel Prize for their work on the interpretation of the genetic code and its function in protein synthesis. That same year marked a pivotal accomplishment in molecular biology and biochemistry.

Additional distinctions include becoming a Fellow of the American Association for the Advancement of Science (AAAS) in 1966 and being inducted as a Member of the National Academy of Sciences in the same year. In 1987, Khorana was honored with the US President's National Medal of Science. The official citation noted contributions that advanced the understanding of gene structure, membrane function, and vision, emphasizing the impact of this research on biological and chemical sciences. The medal was presented by President Reagan at a White House ceremony on June 25, 1987.

Khorana's work is characterized by its foundational influence on molecular genetics and biochemistry, particularly in areas relating to the genetic code and protein synthesis. They pursued research that integrated gene structure knowledge with membrane physiology and visual processes, indicating a multidisciplinary approach that intersected genetics, cell biology, and biochemistry.

The available data does not list specific publications or co-authors, but Khorana's career affiliation with MIT and prominent recognitions place them among leading figures in scientific research during their active years.

Best Publications

  • Structure and function in rhodopsin: High-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line

    Philip J. Reeves;Nico Callewaert;Roland Contreras;H. Gobind Khorana

  • Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin

    T P Sakmar;R R Franke;H G Khorana

  • Vibrational spectroscopy of bacteriorhodopsin mutants: light-driven proton transport involves protonation changes of aspartic acid residues 85, 96, and 212

    Mark S. Braiman;Tatsushi M. Mogi;Thomas M. Marti;Lawrence J. Stern

  • Transmembrane protein structure: spin labeling of bacteriorhodopsin mutants

    C Altenbach;T Marti;HG Khorana;WL Hubbell

  • Rhodopsin, photoreceptor of the rod cell. An emerging pattern for structure and function.

    H G Khorana

  • Expression of a synthetic bovine rhodopsin gene in monkey kidney cells.

    D D Oprian;R S Molday;R J Kaufman;H G Khorana

  • Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin

    S S Karnik;T P Sakmar;H B Chen;H G Khorana

  • Studies on polynucleotides. XCVI. Repair replication of short synthetic DNA's as catalyzed by DNA polymerases

    K. Kleppe;E. Ohtsuka;R. Kleppe;Ian J Molineux

  • Rhodopsin mutants that bind but fail to activate transducin

    RR Franke;B Konig;TP Sakmar;HG Khorana

  • Assembly of functional rhodopsin requires a disulfide bond between cysteine residues 110 and 187.

    S S Karnik;H G Khorana

  • Structural studies on transmembrane proteins. 2. Spin labeling of bacteriorhodopsin mutants at unique cysteines.

    C. Altenbach;S.L. Flitsch;H.G. Khorana;W.L. Hubbell

  • Aspartic acid-96 is the internal proton donor in the reprotonation of the Schiff base of bacteriorhodopsin

    H Otto;T Marti;M Holz;T Mogi

  • Bacteriorhodopsin, a membrane protein that uses light to translocate protons.

    H G Khorana

  • Total Synthesis of the Gene for an Alanine Transfer Ribonucleic Acid from Yeast

    K L Agarwal;H Büchi;M H Caruthers;N Gupta

  • Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin.

    R.R. Franke;T.P. Sakmar;R.M. Graham;H.G. Khorana

  • Aspartic acid substitutions affect proton translocation by bacteriorhodopsin.

    T Mogi;L J Stern;T Marti;B H Chao

  • The bacteriorhodopsin gene

    R Dunn;J McCoy;M Simsek;A Majumdar

  • Physical characterization and simultaneous purification of bacteriophage T4 induced polynucleotide kinase, polynucleotide ligase, and deoxyribonucleic acid polymerase.

    A Panet;J H van de Sande;P C Loewen;H G Khorana

  • A single amino acid substitution in rhodopsin (lysine 248----leucine) prevents activation of transducin.

    R R Franke;T P Sakmar;D D Oprian;H G Khorana

  • Total synthesis and expression of a gene for the α-subunit of bovine rod outer segment guanine nucleotide-binding protein (transducin)

    Thomas P. Sakmar;H.Gobind Khorana

Frequent Co-Authors

Marvin H. Caruthers
Marvin H. Caruthers University of Colorado Boulder
Maarten P. Heyn
Maarten P. Heyn Freie Universität Berlin
Wayne L. Hubbell
Wayne L. Hubbell University of California, Los Angeles
Lawrence J. Stern
Lawrence J. Stern University of Massachusetts Chan Medical School
Christian Altenbach
Christian Altenbach University of California, Los Angeles
Judith Klein-Seetharaman
Judith Klein-Seetharaman Arizona State University
Robert D. Wells
Robert D. Wells Texas A&M University
Sriram Subramaniam
Sriram Subramaniam University of British Columbia
Santanu Bhattacharya
Santanu Bhattacharya Indian Institute of Science

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