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Chemistry

D-Index
66
Citations
26049
World Ranking
7149
National Ranking
2127

Research.com Recognitions

  • 2017 - Fellow, National Academy of Inventors
  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2014 - NAS Award in Chemical Sciences, National Academy of Sciences (US) For his pioneering contributions to the chemical synthesis of DNA and RNA that made it possible to decode and encode genes and genomes.
  • 2006 - US President's National Medal of Science "For his work in developing robust methods for the chemical synthesis of DNA, which has enabled genetic engineering of new biopharmaceuticals, forensic "DNA fingerprinting," and the human genome project.", Awarded by President George W. Bush in a White House ceremony on July 27, 2007.
  • 2006 - Promega Biotechnology Research Award, American Society for Microbiology
  • 2005 - NAS Award for Chemistry in Service to Society, U.S. National Academy of Sciences For his invention and development of chemical reagents and methods currently used for the automated synthesis of DNA oligonucleotides (i.e., the gene machine).
  • 1994 - Member of the National Academy of Sciences
  • 1994 - Fellow of the American Academy of Arts and Sciences
  • 1980 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Marvin H. Caruthers is affiliated with the University of Colorado Boulder in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with a particular focus on molecular biology at the subfield level. Their scientific work encompasses various specialized topics including RNA research and splicing, RNA modifications and cancer, RNA interference and gene delivery, DNA and nucleic acid chemistry, neurogenetic and muscular disorders research, RNA and protein synthesis mechanisms, and advanced biosensing and bioanalysis techniques.

They have contributed to several scholarly articles, notable among these are:

  • Synthesis and Characterization of Thiophosphoramidate Morpholino Oligonucleotides and Chimeras (2020), Journal of the American Chemical Society
  • Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention (2021), Nature Communications
  • Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing (2022), Proceedings of the National Academy of Sciences
  • DNA Analogues Modified at the Nonlinking Positions of Phosphorus (2020), Accounts of Chemical Research
  • Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression (2023), Cell Reports

Frequently collaborating with other researchers, their key coauthors include Katarzyna Jastrzębska, Kavitha Sudheendran, Heera K. Langner, Gabrijela Dumbović, and Ulrich Braunschweig. Their work appears in various scientific venues, most often in Nature Communications and bioRxiv (Cold Spring Harbor Laboratory), with additional publications in the Proceedings of the National Academy of Sciences, Cell Reports, and the Journal of the American Chemical Society.

The scientist has received several awards acknowledging their contributions to science and chemical synthesis. These include being named a Fellow of the American Association for the Advancement of Science (AAAS) and the National Academy of Inventors in 2017. They were awarded the NAS Award in Chemical Sciences by the National Academy of Sciences (US) in 2014 for contributions to the chemical synthesis of DNA and RNA relevant to genetic decoding and encoding.

Other recognitions include the Promega Biotechnology Research Award from the American Society for Microbiology in 2006 and the US President's National Medal of Science the same year, awarded for pioneering robust chemical synthesis methods for DNA impacting genetic engineering, biopharmaceutical development, forensic DNA fingerprinting, and the Human Genome Project. Earlier honors include the NAS Award for Chemistry in Service to Society in 2005 for inventions used in automated DNA oligonucleotide synthesis and fellowships with the American Academy of Arts and Sciences, the John Simon Guggenheim Memorial Foundation, and membership in the National Academy of Sciences.

Best Publications

  • Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

    S.L. Beaucage;M.H. Caruthers

  • Process for preparing polynucleotides

    Marvin H. Caruthers;Mark D. Matteucci

  • Improved free-energy parameters for predictions of RNA duplex stability

    Susan M. Freier;Ryszard Kierzek;John A. Jaeger;Naoki Sugimoto

  • SYNTHESIS OF DEOXYOLIGONUCLEOTIDES ON A POLYMER SUPPORT

    M. D. Matteucci;M. H. Caruthers

  • Gene synthesis machines: DNA chemistry and its uses

    Marvin H. Caruthers

  • An investigation of several deoxynucleoside phosphoramidites useful for synthesizing deoxyoligonucleotides

    L.J. McBride;M.H. Caruthers

  • Nucleosides useful in the preparation of polynucleotides

    Marvin H. Caruthers;Mark D. Matteucci

  • Process for oligonucleotide synthesis using phosphoramidite intermediates

    Caruthers Marvin H;Beaucage Serge L

  • Chemical synthesis of deoxyoligonucleotides by the phosphoramidite method.

    M H Caruthers;A D Barone;S L Beaucage;D R Dodds

  • Metal ion catalysis in the Tetrahymena ribozyme reaction

    Joseph A. Piccirilli;Joseph S. Vyle;Joseph S. Vyle;Marvin H. Caruthers;Thomas R. Cech

  • Process for oligonucleo tide synthesis using phosphormidite intermediates

    Marvin H. Caruthers;Serge L. Beaucage

  • Synthesis of high-quality libraries of long (150mer) oligonucleotides by a novel depurination controlled process

    Emily M. LeProust;Bill J. Peck;Konstantin Spirin;Heather Brummel McCuen

  • Phosphoramidite nucleoside compounds

    Marvin H. Caruthers;Serge L. Beaucage

  • Total Synthesis of the Gene for an Alanine Transfer Ribonucleic Acid from Yeast

    K L Agarwal;H Büchi;M H Caruthers;N Gupta

  • Novel RNA Synthesis Method Using 5‘-O-Silyl-2‘-O-orthoester Protecting Groups.

    Stephen A. Scaringe;Francine E. Wincott;Marvin H. Caruthers

  • Chemical synthesis of DNA and DNA analogs

    Marvin H. Caruthers

  • In situ activation of bis-dialkylaminophosphines—a new method for synthesizing deoxyoligonucleotides on polymer supports

    A.D. Barone;J.-Y. Tang;M.H. Caruthers

  • Phosphorodithioate DNA as a potential therapeutic drug

    WS Marshall;MH Caruthers

  • Nucleotide chemistry. 16. Amidine protecting groups for oligonucleotide synthesis

    Lincoln J. McBride;Ryszard. Kierzek;Serge L. Beaucage;Marvin H. Caruthers

  • Studies on polynucleotides. 103. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast.

    H.G. Khorana;K.L. Agarwal;H. Büchi;M.H. Caruthers

  • Synthesis of oligodeoxynucleoside phosphorodithioates via thioamidites

    Wolfgang K. D. Brill;Jin Yan Tang;Yun Xi Ma;Marvin H. Caruthers

Frequent Co-Authors

Ryszard Kierzek
Ryszard Kierzek Polish Academy of Sciences
Peter H. Seeberger
Peter H. Seeberger Max Planck Society
Douglas H. Turner
Douglas H. Turner University of Rochester
Arnold J. Berk
Arnold J. Berk University of California, Los Angeles
Thomas R. Cech
Thomas R. Cech University of Colorado Boulder
Craig Montell
Craig Montell University of California, Santa Barbara
Fernando Ferreira
Fernando Ferreira Universidade de São Paulo
Michael W. Hunkapiller
Michael W. Hunkapiller Pacific Biosciences (United States)

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