D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 61 Citations 21,866 236 World Ranking 5880 National Ranking 1894

Research.com Recognitions

Awards & Achievements

2017 - Fellow of the American Association for the Advancement of Science (AAAS)

2017 - Fellow, National Academy of Inventors

2014 - NAS Award in Chemical Sciences, National Academy of Sciences (US) For his pioneering contributions to the chemical synthesis of DNA and RNA that made it possible to decode and encode genes and genomes.

2006 - US President's National Medal of Science "For his work in developing robust methods for the chemical synthesis of DNA, which has enabled genetic engineering of new biopharmaceuticals, forensic "DNA fingerprinting," and the human genome project.", Awarded by President George W. Bush in a White House ceremony on July 27, 2007.

2006 - Promega Biotechnology Research Award, American Society for Microbiology

2005 - NAS Award for Chemistry in Service to Society, U.S. National Academy of Sciences For his invention and development of chemical reagents and methods currently used for the automated synthesis of DNA oligonucleotides (i.e., the gene machine).

1994 - Fellow of the American Academy of Arts and Sciences

1994 - Member of the National Academy of Sciences

1980 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

What is he best known for?

The fields of study he is best known for:

  • DNA
  • Gene
  • Enzyme

Marvin H. Caruthers focuses on Organic chemistry, Biochemistry, Combinatorial chemistry, Phosphoramidite and Oligonucleotide. His Organic chemistry research includes themes of Nucleic acid and Nucleoside. His Combinatorial chemistry study incorporates themes from Protein sequencing, Polymer, Gene, Chemical synthesis and Computational biology.

His Phosphoramidite research incorporates elements of Deoxyribonucleotide, Oligoribonucleotides and Oligonucleotide synthesis. His Oligonucleotide research integrates issues from RNA, Molecular biology, Enzyme inhibitor and DNA synthesis. His work in Polynucleotide addresses subjects such as Inorganic polymer, which are connected to disciplines such as Scientific method.

His most cited work include:

  • Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis (1993 citations)
  • Process for preparing polynucleotides (1385 citations)
  • Improved free-energy parameters for predictions of RNA duplex stability (1197 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in DNA, Combinatorial chemistry, Biochemistry, Stereochemistry and Oligonucleotide. The various areas that he examines in his DNA study include RNA, RNase H, Molecular biology, HeLa and Chemical synthesis. His studies in Combinatorial chemistry integrate themes in fields like Nucleic acid, DNA synthesis, Nucleoside, Phosphoramidite and Organic chemistry.

His research integrates issues of Structural gene, Lac repressor, Duplex and Nucleotide in his study of Stereochemistry. The concepts of his Nucleotide study are interwoven with issues in Binding site and Monomer. His Oligonucleotide study combines topics from a wide range of disciplines, such as Phosphodiester bond, Nucleophile and Solid-phase synthesis.

He most often published in these fields:

  • DNA (27.70%)
  • Combinatorial chemistry (28.04%)
  • Biochemistry (25.34%)

What were the highlights of his more recent work (between 2004-2020)?

  • DNA (27.70%)
  • Combinatorial chemistry (28.04%)
  • Oligonucleotide (22.30%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in DNA, Combinatorial chemistry, Oligonucleotide, Organic chemistry and RNA. His DNA study is concerned with Biochemistry in general. Marvin H. Caruthers has included themes like Protecting group, Synthon, Polynucleotide, Nucleoside and Monomer in his Combinatorial chemistry study.

The Nucleoside study combines topics in areas such as Chemical synthesis, Nucleic acid and Moiety. His Oligonucleotide study integrates concerns from other disciplines, such as Molecular biology, RNase P, Exon skipping and Stereochemistry. His study in RNA is interdisciplinary in nature, drawing from both Complementary DNA, Transfection and Cell biology.

Between 2004 and 2020, his most popular works were:

  • Synthesis of high-quality libraries of long (150mer) oligonucleotides by a novel depurination controlled process (253 citations)
  • Streamlined Process for the Chemical Synthesis of RNA Using 2′-O-Thionocarbamate-Protected Nucleoside Phosphoramidites in the Solid Phase (57 citations)
  • Thiocarbon-protecting groups for rna synthesis (50 citations)

In his most recent research, the most cited papers focused on:

  • DNA
  • Gene
  • Enzyme

His main research concerns Combinatorial chemistry, Monomer, Polynucleotide, RNA and Nucleoside. His Combinatorial chemistry research focuses on Phosphoramidite and how it connects with Chemical synthesis. His work carried out in the field of Polynucleotide brings together such families of science as Nucleotide and Stereochemistry.

His study explores the link between RNA and topics such as DNA that cross with problems in Nanotechnology. His study focuses on the intersection of Nucleoside and fields such as Nucleic acid with connections in the field of Organic chemistry, Aryl and Thiocarbonate. In Thiocarbonate, Marvin H. Caruthers works on issues like Silylation, which are connected to Oligonucleotide.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

S.L. Beaucage;M.H. Caruthers.
Tetrahedron Letters (1981)

3244 Citations

Process for preparing polynucleotides

Marvin H. Caruthers;Mark D. Matteucci.
(1981)

2216 Citations

Improved free-energy parameters for predictions of RNA duplex stability

Susan M. Freier;Ryszard Kierzek;John A. Jaeger;Naoki Sugimoto.
Proceedings of the National Academy of Sciences of the United States of America (1986)

2088 Citations

Synthesis of deoxyoligonucleotides on a polymer support

M. D. Matteucci;M. H. Caruthers.
Journal of the American Chemical Society (1981)

1418 Citations

Gene synthesis machines: DNA chemistry and its uses

Marvin H. Caruthers.
Science (1985)

1169 Citations

Phosphoramidite compounds and processes

Caruthers Marvin;Beaucage Serge L.
(1981)

871 Citations

Nucleosides useful in the preparation of polynucleotides

Marvin H. Caruthers;Mark D. Matteucci.
(1982)

830 Citations

An investigation of several deoxynucleoside phosphoramidites useful for synthesizing deoxyoligonucleotides

L.J. McBride;M.H. Caruthers.
Tetrahedron Letters (1983)

823 Citations

Process for oligonucleotide synthesis using phosphoramidite intermediates

Caruthers Marvin H;Beaucage Serge L.
(1990)

580 Citations

Metal ion catalysis in the Tetrahymena ribozyme reaction

Joseph A. Piccirilli;Joseph S. Vyle;Joseph S. Vyle;Marvin H. Caruthers;Thomas R. Cech.
Nature (1993)

521 Citations

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