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Biology and Biochemistry

D-Index
59
Citations
12330
World Ranking
12545
National Ranking
350

Overview

Tony Velkov is affiliated with the University of Melbourne in Australia. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a strong focus on molecular medicine and pharmacology. They have produced a substantial body of work addressing antibiotic resistance, pharmacokinetics of antibiotics, and infectious diseases.

The main fields of study for Velkov include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, their work further concentrates on subfields such as:

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Epidemiology
  • Infectious Diseases

Their research covers topics including:

  • Antibiotic Resistance in Bacteria
  • Antibiotics Pharmacokinetics and Efficacy
  • Tuberculosis Research and Epidemiology
  • Vibrio bacteria research studies
  • Antimicrobial Peptides and Activities
  • Epilepsy research and treatment
  • Bacteriophages and microbial interactions

Velkov's recent papers demonstrate engagement with antimicrobial agents and bacterial resistance mechanisms. Selected publications include:

  • "Rescuing the Last-Line Polymyxins: Achievements and Challenges," 2021, Pharmacological Reviews
  • "Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination," 2020, JCI Insight
  • "The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems," 2022, Antioxidants
  • "A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens," 2022, Nature Communications
  • "The Antimicrobial Activity of Cannabinoids," 2020, Antibiotics

Velkov frequently publishes in venues related to infectious diseases and pharmacology, with multiple contributions to journals such as:

  • ACS Infectious Diseases
  • Antioxidants
  • Antimicrobial Agents and Chemotherapy
  • Computational and Structural Biotechnology Journal
  • Antibiotics

They collaborate regularly with other researchers, including Jian Li, Yan Zhu, Maytham Hussein, Gauri G. Rao, and Chongshan Dai. These professional collaborations highlight a network of expertise in antimicrobial resistance and drug efficacy.

Best Publications

  • Structure—Activity Relationships of Polymyxin Antibiotics

    Tony Velkov;Philip Thompson;Roger Leigh Nation;Jian Li

  • Pharmacology of polymyxins: new insights into an 'old' class of antibiotics.

    Tony Velkov;Kade Douglas Roberts;Roger Leigh Nation;Philip Thompson

  • Colistin and Polymyxin B: Peas in a Pod, or Chalk and Cheese?

    Roger Leigh Nation;Tony Velkov;Jian Li

  • A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

    Zakuan Zainy Deris;Jesmin Akter;Sivashangarie Sivanesan;Kade Douglas Roberts

  • Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?

    Thien B. Tran;Tony Velkov;Roger L. Nation;Alan Forrest

  • The rise and spread of mcr plasmid-mediated polymyxin resistance

    Sue C Nang;Jian Li;Tony Velkov

  • Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination.

    Guido Veit;Ariel Roldan;Mark A Hancock;Dillon F Da Fonte

  • Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics against Multidrug-Resistant Gram-negative Bacteria.

    Kade D. Roberts;Mohammad A. K. Azad;Jiping Wang;Andrew S. Horne

  • Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis

    Chongshan Dai;Xilong Xiao;Daowen Li;Sun Tun

  • Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function

    Mark A Baker;Anita S Weinberg;Louise Hetherington;Ana-Izabel Villaverde

  • Head and flagella subcompartmental proteomic analysis of human spermatozoa

    Mark A. Baker;Nenad Naumovski;Louise Hetherington;Anita Weinberg

  • T-2 toxin neurotoxicity: role of oxidative stress and mitochondrial dysfunction.

    Chongshan Dai;Chongshan Dai;Xilong Xiao;Feifei Sun;Yuan Zhang

  • Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria.

    Zakuan Zainy Deris;James David Swarbrick;Kade Douglas Roberts;Mohammad Abul Kalam Azad

  • Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’

    Tony Velkov;Kade Douglas Roberts;Roger Leigh Nation;Jiping Wang

  • Lycopene Attenuates Colistin-Induced Nephrotoxicity in Mice via Activation of the Nrf2/HO-1 Pathway

    Chongshan Dai;Shusheng Tang;Sijun Deng;Shen Zhang

  • Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells

    Mohammad Abul Kalam Azad;Benjamin Arthur Llewellyn Finnin;Anima Poudyal;Kathryn Erin Davis

  • Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis

    Chongshan Dai;Giuseppe D Ciccotosto;Roberto Cappai;Shusheng Tang

  • Pharmacokinetics of four different brands of colistimethate and formed colistin in rats

    Hui He;Ji Chang Li;Ji Chang Li;Roger Leigh Nation;Jovan Jacob

  • Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead

    Tony Velkov;Nusaibah Abdul Rahim;Qi Tony Zhou;Hak-Kim Chan

  • Self-assembly behavior of colistin and its prodrug colistin methanesulfonate: implications for solution stability and solubilization.

    Stephanie Jean Wallace;Jian Li;Roger Leigh Nation;Richard John Prankerd

Frequent Co-Authors

Roger L. Nation
Roger L. Nation Monash University
Daniel Hoyer
Daniel Hoyer University of Melbourne
Mark A. Baker
Mark A. Baker University of Newcastle Australia
Mark E. Cooper
Mark E. Cooper Monash University
Darren J. Creek
Darren J. Creek Monash University
Thomas P. Davis
Thomas P. Davis University of Queensland
Falk Schreiber
Falk Schreiber University of Konstanz
Christopher J.H. Porter
Christopher J.H. Porter Monash University
Alan Forrest
Alan Forrest University at Buffalo, State University of New York
Michael R. Whittaker
Michael R. Whittaker Monash University

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