World's Best Scientists 2026 revealed!

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Microbiology

D-Index
44
Citations
7598
World Ranking
5138
National Ranking
1975

Overview

Brian T. Tsuji is affiliated with the University at Buffalo, State University of New York in the United States. Their research primarily focuses on antibiotic resistance and pharmacokinetics in bacteria, contributing to the fields of biochemistry, genetics, molecular biology, and medicine.

The scientist has published extensively in areas such as molecular medicine, pharmacology, molecular biology, endocrinology, and epidemiology. Their key topics of study include antibiotic resistance in bacteria, antibiotics pharmacokinetics and efficacy, Vibrio bacteria research studies, malaria research and control, pneumonia and respiratory infections, tuberculosis research and epidemiology, and bacterial identification and susceptibility testing.

Brian T. Tsuji's recent papers illustrate their work in investigating antibiotic combinations and dosing strategies against resistant bacterial strains. Notable publications include:

  • Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection model (2020, Journal of Antimicrobial Chemotherapy)
  • Using machine learning to optimize antibiotic combinations: dosing strategies for meropenem and polymyxin B against carbapenem-resistant Acinetobacter baumannii (2020, Clinical Microbiology and Infection)
  • Research priorities towards precision antibiotic therapy to improve patient care (2022, The Lancet Microbe)
  • Polymyxin Triple Combinations against Polymyxin-Resistant, Multidrug-Resistant, KPC-Producing Klebsiella pneumoniae (2020, Antimicrobial Agents and Chemotherapy)
  • Combatting the Rising Tide of Antimicrobial Resistance: Pharmacokinetic/Pharmacodynamic Dosing Strategies for Maximal Precision (2020, International Journal of Antimicrobial Agents)

Frequent co-authorships accompany their publications, highlighting collaboration with other researchers, including:

  • Patricia N. Holden
  • Jürgen B. Bulitta
  • Jian Li
  • Nicholas M. Smith
  • Alan Forrest

Their research is often published in venues with repeated appearances, signaling ongoing contributions within the same academic circles. These include:

  • UNC Libraries
  • Antimicrobial Agents and Chemotherapy
  • Open Forum Infectious Diseases
  • Clinical Microbiology and Infection
  • International Journal of Antimicrobial Agents

Brian T. Tsuji's body of work demonstrates a focus on understanding and combating antimicrobial resistance through pharmacologic and molecular approaches, reflecting a multidisciplinary expertise in both laboratory and clinical research contexts.

Best Publications

  • International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti-infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP).

    Brian T. Tsuji;Jason M. Pogue;Alexandre P. Zavascki;Mical Paul;Mical Paul

  • Resurgence of colistin: a review of resistance, toxicity, pharmacodynamics, and dosing.

    Lauren M Lim;Neang S Ly;Dana Anderson;Jenny C Yang

  • Framework for optimisation of the clinical use of colistin and polymyxin B : the Prato polymyxin consensus

    Roger Leigh Nation;Jian Li;Otto Cars;William Couet

  • Linezolid-Associated Peripheral and Optic Neuropathy, Lactic Acidosis, and Serotonin Syndrome

    Masashi Narita;Brian T Tsuji;Victor L Yu

  • Pharmacokinetic/Pharmacodynamic Investigation of Colistin against Pseudomonas aeruginosa Using an In Vitro Model

    Phillip John Bergen;Jurgen B Bulitta;Alan Forrest;Brian Tsuji

  • Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?

    Thien B. Tran;Tony Velkov;Roger L. Nation;Alan Forrest

  • Ampicillin Enhances Daptomycin- and Cationic Host Defense Peptide-Mediated Killing of Ampicillin- and Vancomycin-Resistant Enterococcus faecium

    George Sakoulas;Arnold S. Bayer;Arnold S. Bayer;Joseph Pogliano;Brian T. Tsuji

  • Short-Course Gentamicin in Combination with Daptomycin or Vancomycin against Staphylococcus aureus in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations

    Brian T. Tsuji;Brian T. Tsuji;Michael J. Rybak;Michael J. Rybak;Michael J. Rybak

  • A Comparative Review of the Lipoglycopeptides: Oritavancin, Dalbavancin, and Telavancin

    Michael T Guskey;Brian T Tsuji;Brian T Tsuji

  • Synergistic Killing of Multidrug-Resistant Pseudomonas aeruginosa at Multiple Inocula by Colistin Combined with Doripenem in an In Vitro Pharmacokinetic/Pharmacodynamic Model

    Phillip J. Bergen;Brian T. Tsuji;Jurgen B. Bulitta;Alan Forrest

  • Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models.

    Cornelia B Landersdorfer;Cornelia B Landersdorfer;Jiping Wang;Veronika Wirth;Ke Chen

  • Attenuation of Colistin Bactericidal Activity by High Inoculum of Pseudomonas aeruginosa Characterized by a New Mechanism-Based Population Pharmacodynamic Model

    Jurgen Bernd Bulitta;Jenny C Yang;Liliana Yohonn;Liliana Yohonn;Neang S Ly

  • Community- and health care-associated methicillin-resistant Staphylococcus aureus: a comparison of molecular epidemiology and antimicrobial activities of various agents.

    Brian T. Tsuji;Michael J. Rybak;Michael J. Rybak;Michael J. Rybak;Chrissy M. Cheung;Muhammad Amjad;Muhammad Amjad

  • The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections

    T. Tängdén;V. Ramos Martín;T. W. Felton;E. I. Nielsen

  • Evaluation of Accessory Gene Regulator (agr) Group and Function in the Proclivity towards Vancomycin Intermediate Resistance in Staphylococcus aureus

    Brian T. Tsuji;Michael J. Rybak;Michael J. Rybak;Michael J. Rybak;Kerry L. Lau;George Sakoulas

  • Clinically Relevant Plasma Concentrations of Colistin in Combination with Imipenem Enhance Pharmacodynamic Activity against Multidrug-Resistant Pseudomonas aeruginosa at Multiple Inocula

    Phillip J. Bergen;Alan Forrest;Jürgen B. Bulitta;Brian T. Tsuji

  • Synergistic combinations of polymyxins

    Justin R. Lenhard;Justin R. Lenhard;Roger L. Nation;Brian T. Tsuji

  • Synergistic Activity of Colistin and Rifampin Combination against Multidrug-Resistant Acinetobacter baumannii in an In Vitro Pharmacokinetic/Pharmacodynamic Model

    Hee Ji Lee;Phillip John Bergen;Jurgen Bernd Bulitta;Jurgen Bernd Bulitta;Brian Tsuji

  • Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosa.

    Jiirgen B. Bulitta;Neang S. Ly;Jenny C. Yang;Alan Forrest

  • Pharmacokinetics of four different brands of colistimethate and formed colistin in rats

    Hui He;Ji Chang Li;Ji Chang Li;Roger Leigh Nation;Jovan Jacob

  • Consistent Global Approach on Reporting of Colistin Doses to Promote Safe and Effective Use

    Roger L. Nation;Jian Li;Otto Cars;William Couet

Frequent Co-Authors

Jürgen B. Bulitta
Jürgen B. Bulitta St. Jude Children's Research Hospital
Alan Forrest
Alan Forrest University at Buffalo, State University of New York
Roger L. Nation
Roger L. Nation Monash University
Michael J. Rybak
Michael J. Rybak Wayne State University
David L. Paterson
David L. Paterson University of Queensland
Tony Velkov
Tony Velkov University of Melbourne
George Sakoulas
George Sakoulas University of California, San Diego
Thomas P. Lodise
Thomas P. Lodise Albany College of Pharmacy and Health Sciences
Barry N. Kreiswirth
Barry N. Kreiswirth Center for Discovery and Innovation
Michael J. Satlin
Michael J. Satlin Cornell University

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