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Biology and Biochemistry

D-Index
82
Citations
23418
World Ranking
3713
National Ranking
119

Overview

Sriram Subramaniam is affiliated with the University of British Columbia in Canada. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant contributions to subfields including Molecular Biology, Infectious Diseases, Structural Biology, Radiology, Nuclear Medicine and Imaging, and Materials Chemistry.

The primary research topics covered by Subramaniam's work include SARS-CoV-2 and COVID-19 Research, Advanced Electron Microscopy Techniques and Applications, Monoclonal and Polyclonal Antibodies Research, COVID-19 Clinical Research Studies, Enzyme Structure and Function, Protein Structure and Dynamics, and Methane Hydrates and Related Phenomena.

Subramaniam has published extensively, with notable papers including:

  • "SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex" (2022), Science
  • "Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies" (2021), PLoS Biology
  • "Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation" (2022), Nature Chemical Biology
  • "High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models" (2020), Cell
  • "Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants" (2022), Nature Communications

The frequent co-authors collaborating with Subramaniam include Alison Berezuk, Xing Zhu, Shanti Swaroop Srivastava, Sagar Chittori, and Theo Humphreys.

Subramaniam's work has appeared predominantly in publication venues such as OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information), bioRxiv (Cold Spring Harbor Laboratory), IUCrJ, Nature Communications, and Cell Reports. The number of publications in these venues reflect their active engagement with both governmental and academic platforms supporting scientific dissemination.

Best Publications

  • A collaborative framework for 3D alignment and classification of heterogeneous subvolumes in cryo-electron tomography

    Oleg Kuybeda;Gabriel A. Frank;Alberto Bartesaghi;Mario Borgnia

  • Molecular architecture of native HIV-1 gp120 trimers.

    Jun Liu;Alberto Bartesaghi;Mario J. Borgnia;Guillermo Sapiro

  • Modeling Customer Lifetime Value

    Sunil Gupta;Dominique M. Hanssens;Bruce G.S. Hardie;Wiliam Kahn

  • Molecular mechanism of vectorial proton translocation by bacteriorhodopsin.

    Sriram Subramaniam;Richard Henderson

  • Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery.

    Alan Merk;Alberto Bartesaghi;Soojay Banerjee;Veronica Falconieri

  • 2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor

    Alberto Bartesaghi;Alan Merk;Soojay Banerjee;Doreen Matthies

  • Electron diffraction analysis of structural changes in the photocycle of bacteriorhodopsin.

    Sriram Subramaniam;Mark Gerstein;Dieter Oesterhelt;Richard Henderson

  • Mitochondrial reticulum for cellular energy distribution in muscle

    Brian Glancy;Lisa M. Hartnell;Daniela Malide;Zu Xi Yu

  • Site-specific 3D imaging of cells and tissues with a dual beam microscope.

    Jurgen A.W. Heymann;Mike Hayles;Ingo Gestmann;Lucille A. Giannuzzi

  • 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition

    Soojay Banerjee;Alberto Bartesaghi;Alan Merk;Prashant Rao

  • Cryo-electron microscopy--a primer for the non-microscopist.

    Jacqueline L. S. Milne;Mario J. Borgnia;Alberto Bartesaghi;Erin E. H. Tran

  • Protein conformational changes in the bacteriorhodopsin photocycle.

    Sriram Subramaniam;Martin Lindahl;Per Bullough;A.R Faruqi

  • Three-dimensional structure of a bacterial oxalate transporter.

    Teruhisa Hirai;Jürgen A.W. Heymann;Dan Shi;Rafiquel Sarker

  • Structural mechanism of trimeric HIV-1 envelope glycoprotein activation.

    Erin E. H. Tran;Mario J. Borgnia;Oleg Kuybeda;David M. Schauder

  • Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

    Yanyong Kang;Oleg Kuybeda;Parker W. de Waal;Somnath Mukherjee

  • Focused ion beams in biology

    Kedar Narayan;Sriram Subramaniam

  • 3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells

    Richard L. Felts;Kedar Narayan;Jacob D. Estes;Dan Shi

  • Structural mechanism of glutamate receptor activation and desensitization

    Joel R. Meyerson;Janesh Kumar;Sagar Chittori;Prashant Rao

  • Molecular Architecture of Native HIV-1 gp 120 Trimers

    J. Liu;A. Bartesaghi;M. J. Borgnia;G. Sapiro

  • Electron diffraction analysis ofstructural changesinthe photocycle ofbacteriorhodopsin

    Sriram Subramaniam;Dieter Oesterhelt

Frequent Co-Authors

Guillermo Sapiro
Guillermo Sapiro Princeton University
Richard N. Perham
Richard N. Perham University of Cambridge
Peter J. Peters
Peter J. Peters Maastricht University
Mark L. Mayer
Mark L. Mayer National Institutes of Health
Jun Liu
Jun Liu Yale University
Ulrich Baxa
Ulrich Baxa Leidos (United States)
Bernard R. Brooks
Bernard R. Brooks National Institutes of Health
Dimiter S. Dimitrov
Dimiter S. Dimitrov University of Pittsburgh
Dieter Oesterhelt
Dieter Oesterhelt Max Planck Society

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