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Biology and Biochemistry

D-Index
50
Citations
8359
World Ranking
17702
National Ranking
7257

Overview

Xiang-Lei Yang is a researcher affiliated with the Scripps Research Institute in the United States, specializing in biochemistry, genetics, and molecular biology. Their primary research focuses on molecular biology, with an emphasis on RNA and protein synthesis mechanisms, RNA modifications and cancer, as well as RNA research and splicing.

Their work also covers RNA regulation and disease, hereditary neurological disorders, cancer-related molecular mechanisms, genomics, and phylogenetic studies. These topics illustrate a broad engagement with cellular and molecular processes with relevance to disease and genetic regulation.

Xiang-Lei Yang has contributed to the scientific community through publications in key journals and research venues. Frequent publication venues include:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Nature Cell Biology
  • Proceedings of the National Academy of Sciences

Some of the recent papers authored by or involving Xiang-Lei Yang are:

  • "PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications", 2021, Nature Cell Biology
  • "Inflammatory platelet production stimulated by tyrosyl-tRNA synthetase mimicking viral infection", 2022, Proceedings of the National Academy of Sciences
  • "Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase", 2021, Nature Communications
  • "Multi-Omics Database Analysis of Aminoacyl-tRNA Synthetases in Cancer", 2020, Genes
  • "Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis", 2020, PLoS Biology

Xiang-Lei Yang frequently collaborates with several researchers including Ryan Shapiro, Taisuke Kanaji, Paul Schimmel, Bernhard Kuhle, and Sachiko Kanaji, reflecting a collaborative approach in their research projects.

Their publication record includes contributions to both fundamental and applied aspects of the biosciences, with the integration of multi-omics and cellular signaling mechanisms being notable elements.

Best Publications

  • Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

    Ryuta Ishimura;Gabor Nagy;Ivan Dotu;Huihao Zhou

  • New functions of aminoacyl-tRNA synthetases beyond translation

    Min Guo;Xiang-Lei Yang;Paul Schimmel

  • Structural studies of atom-specific anticancer drugs acting on DNA

    Xiang-Lei Yang;Andrew H.-J. Wang

  • Functional expansion of human tRNA synthetases achieved by structural inventions.

    Min Guo;Paul Schimmel;Xiang-Lei Yang

  • Correction: Corrigendum: Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases

    Sven Niehues;Julia Bussmann;Georg Steffes;Ines Erdmann

  • Crystal structure of a human aminoacyl-tRNA synthetase cytokine

    Xiang-Lei Yang;Robert J. Skene;Duncan E. McRee;Paul Schimmel

  • Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase.

    Wei Xie;Leslie A. Nangle;Wei Zhang;Paul Schimmel

  • Charcot–Marie–Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect

    Leslie A. Nangle;Wei Zhang;Wei Xie;Xiang-Lei Yang

  • ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase

    Huihao Zhou;Litao Sun;Xiang-Lei Yang;Paul Schimmel

  • PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications.

    Junchao Shi;Yunfang Zhang;Dongmei Tan;Dongmei Tan;Xudong Zhang

  • Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality

    Quansheng Zhou;Mili Kapoor;Min Guo;Rajesh Belani

  • CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase

    Weiwei He;Ge Bai;Huihao Zhou;Na Wei

  • Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis

    Min Chul Park;Taehee Kang;Da Jin;Jung Min Han

  • Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription.

    Yifat Ofir-Birin;Pengfei Fang;Steven P. Bennett;Hui Min Zhang

  • Exome sequencing identifies a significant variant in methionyl-tRNA synthetase (MARS) in a family with late-onset CMT2

    Michael Gonzalez;Heather McLaughlin;Henry Houlden;Min Guo

  • The novel fragment of tyrosyl tRNA synthetase, mini-TyrRS, is secreted to induce an angiogenic response in endothelial cells

    Y. Greenberg;M. King;W. B. Kiosses;K. Ewalt

  • Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases

    Sven Niehues;Julia Bussmann;Georg Steffes;Ines Erdmann

  • Human tRNA synthetase catalytic nulls with diverse functions

    Wing-Sze Lo;Elisabeth Gardiner;Zhiwen Xu;Zhiwen Xu;Ching-Fun Lau;Ching-Fun Lau

  • Unique domain appended to vertebrate tRNA synthetase is essential for vascular development

    Xiaoling Xu;Yi Shi;Hui Min Zhang;Hui Min Zhang;Eric C Swindell

  • Charcot-Marie-Tooth–Linked Mutant GARS Is Toxic to Peripheral Neurons Independent of Wild-Type GARS Levels

    William W. Motley;Kevin L. Seburn;Mir Hussain Nawaz;Kathy E. Miers

Frequent Co-Authors

Paul Schimmel
Paul Schimmel Scripps Research Institute
Litao Sun
Litao Sun Southeast University
Mingjie Zhang
Mingjie Zhang Hong Kong University of Science and Technology
Duncan E. McRee
Duncan E. McRee Scripps Research Institute
Robert W. Burgess
Robert W. Burgess The Jackson Laboratory
Albena Jordanova
Albena Jordanova University of Antwerp
Andrew H.-J. Wang
Andrew H.-J. Wang Academia Sinica
Alan G. Marshall
Alan G. Marshall Florida State University
Magdalena Zernicka-Goetz
Magdalena Zernicka-Goetz California Institute of Technology
Patrick R. Griffin
Patrick R. Griffin Scripps Research Institute

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