World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
12686
World Ranking
14322
National Ranking
6035

Overview

Huidong Shi is affiliated with Augusta University in the United States and specializes in research intersecting Medicine and Biochemistry, Genetics, and Molecular Biology. Their work predominantly focuses on molecular biology, immunology, and oncology, with notable contributions in physiology and genetics.

The scientist has published extensively on topics involving immune cells in cancer, epigenetics and DNA methylation, immune cell function and interaction, and immunotherapy and immune responses. Other research interests include adipose tissue and metabolism, monoclonal and polyclonal antibodies research, as well as cancer immunotherapy and biomarkers.

Noteworthy recent publications include:

  • "CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint" (2020) in Nature Communications
  • "WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape" (2021) in Journal for ImmunoTherapy of Cancer
  • "Persistent STAT5 activation reprograms the epigenetic landscape in CD4 + T cells to drive polyfunctionality and antitumor immunity" (2020) in Science Immunology
  • "Autocrine IL6-Mediated Activation of the STAT3-DNMT Axis Silences the TNFα-RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells" (2020) in Cancer Research
  • "Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity" (2021) in Immunity

The scientist frequently collaborates with a group of researchers, including Tingting Tian, Kaiyu Shang, Fengbo Zhang, Kebin Liu, and Mercy Kehinde-Ige, each with multiple joint publications.

Shi's work appears regularly in several academic venues, reflecting a consistent focus within the field. Key publication venues include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Scientific Reports
  • The Journal of Immunology

Their research spans the broad field of Medicine, comprising over a hundred publications, and is closely aligned with subfields like molecular biology and immunology. The topics covered reflect a multidisciplinary approach, combining genetics, epigenetics, and immunological mechanisms in cancer biology and therapy.

Best Publications

  • Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

    Nagendra Singh;Ashish Gurav;Sathish Sivaprakasam;Evan Brady

  • Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells.

    Warren Fiskus;Yongchao Wang;Arun Sreekumar;Kathleen M. Buckley

  • Methylation-Specific Oligonucleotide Microarray: A New Potential for High-Throughput Methylation Analysis

    Raad S. Gitan;Huidong Shi;Chuan Mu Chen;Pearlly S. Yan

  • Dissecting Complex Epigenetic Alterations in Breast Cancer Using CpG Island Microarrays

    Pearlly S. Yan;Chuan-Mu Chen;Huidong Shi;Farahnaz Rahmatpanah

  • Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing.

    Kristen H. Taylor;Robin S. Kramer;J. Wade Davis;Juyuan Guo

  • Butyrate suppresses colonic inflammation through HDAC1-dependent Fas Upregulation and Fas-mediated apoptosis of T cells

    Mary A. Zimmerman;Nagendra Singh;Pamela Moore Martin;Muthusamy Thangaraju

  • The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion.

    Chunwan Lu;Amy V. Paschall;Huidong Shi;Natasha Savage

  • DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

    Rajneesh Pathania;Sabarish Ramachandran;Selvakumar Elangovan;Ravi Padia

  • Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers

    Susan H. Wei;Chuan Mu Chen;Gordon Strathdee;Jaturon Harnsomburana

  • A genome-wide methylation study on obesity: Differential variability and differential methylation

    Xiaojing Xu;Shaoyong Su;Vernon A. Barnes;Carmen De Miguel

  • Obesity related methylation changes in DNA of peripheral blood leukocytes

    Xiaoling Wang;Haidong Zhu;Harold Snieder;Harold Snieder;Shaoyong Su

  • Metabolomic Profiling Reveals Potential Markers and Bioprocesses Altered in Bladder Cancer Progression

    Nagireddy Putluri;Ali Shojaie;Ali Shojaie;Vihas T Vasu;Vihas T Vasu;Shaiju K Vareed

  • Double RNA Interference of DNMT3b and DNMT1 Enhances DNA Demethylation and Gene Reactivation

    Yu Wei Leu;Farahnaz Rahmatpanah;Huidong Shi;Susan H. Wei

  • Label-free quantitative DNA detection using the liquid core optical ring resonator

    Jonathan D. Suter;Ian M. White;Hongying Zhu;Huidong Shi

  • An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos

    Madhav D. Sharma;Lei Huang;Jeong Hyeon Choi;Eun Joon Lee

  • Triple Analysis of the Cancer Epigenome An Integrated Microarray System for Assessing Gene Expression, DNA Methylation, and Histone Acetylation

    Huidong Shi;Susan H. Wei;Yu Wei Leu;Farahnaz Rahmatpanah

  • Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia.

    Kristen H. Taylor;Keila E. Pena-Hernandez;J. Wade Davis;Gerald L. Arthur

  • Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity

    Xianfeng Wang;Qiang Cao;Qiang Cao;Liqing Yu;Huidong Shi

  • Differential Distribution of DNA Methylation within the RASSF1A CpG Island in Breast Cancer

    Pearlly S. Yan;Huidong Shi;Farahnaz Rahmatpanah;Timothy H.C. Hsiau

  • A systematic evaluation of miRNA:mRNA interactions involved in the migration and invasion of breast cancer cells.

    Daya Luo;James M Wilson;Nikki Harvel;Jimei Liu

Frequent Co-Authors

Tim H M Huang
Tim H M Huang The University of Texas Health Science Center at San Antonio
David H. Munn
David H. Munn Augusta University
Pearlly S. Yan
Pearlly S. Yan The Ohio State University
Dong Xu
Dong Xu University of Missouri
Kebin Liu
Kebin Liu Augusta University
Harold Snieder
Harold Snieder University Medical Center Groningen
Victor X. Jin
Victor X. Jin Medical College of Wisconsin
Muthusamy Thangaraju
Muthusamy Thangaraju Augusta University
Vadivel Ganapathy
Vadivel Ganapathy Texas Tech University Health Sciences Center
Xudong Fan
Xudong Fan University of Michigan–Ann Arbor

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