James P. Snyder

Overview

Best Publications

• The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography

  James H. Nettles;Huilin Li;Ben Cornett;Joseph M. Krahn

  590
  Citations

• Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents

  Brian K. Adams;Eva M. Ferstl;Matthew C. Davis;Marike Herold

  541
  Citations

• The binding conformation of Taxol in β-tubulin: A model based on electron crystallographic density

  James P. Snyder;James H. Nettles;Ben Cornett;Kenneth H. Downing

  509
  Citations

• Polyoxometalate HIV-1 Protease Inhibitors. A New Mode of Protease Inhibition

  Deborah A. Judd;James H. Nettles;Neysa Nevins;James P. Snyder

  446
  Citations

• Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

  Yanqi Chang;Xing Zhang;John R. Horton;Anup K. Upadhyay

  382
  Citations

• Facial symmetry in protein self-assembly.

  Anil K. Mehta;Kun Lu;W. Seth Childers;Yan Liang

  279
  Citations

• EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism.

  Brian K. Adams;Jiyang Cai;Jeff Armstrong;Marike Herold

  279
  Citations

• Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.

  Anlys Olivera;Terry W. Moore;Fang Hu;Andrew P. Brown

  263
  Citations

• Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling

  Philip E Chen;Matthew T Geballe;Phillip J Stansfeld;Alexander R Johnston

  234
  Citations

• Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors

  Kevin Erreger;Matthew T Geballe;Anders S Kristensen;Philip E Chen

  207
  Citations

• Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules

  Malathi Hari;Frank Loganzo;Tami Annable;Xingzhi Tan

  205
  Citations

• DFT calculation of NMR JFF spin-spin coupling constants in fluorinated pyridines

  Verónica Barone;Juan E. Peralta;Rubén H. Contreras;James P. Snyder

  197
  Citations

• Total synthesis of SR 121463 A, a highly potent and selective vasopressin v(2) receptor antagonist.

  Hariharan Venkatesan;Matthew C. Davis;Yesim Altas;James P. Snyder

  195
  Citations

• Inhibition of IκB Kinase-Nuclear Factor-κB Signaling Pathway by 3,5-Bis(2-flurobenzylidene)piperidin-4-one (EF24), a Novel Monoketone Analog of Curcumin

  Andrea L. Kasinski;Yuhong Du;Shala L. Thomas;Jing Zhao

  192
  Citations

• Highly active anticancer curcumin analogues.

  Cara A. Mosley;Dennis C. Liotta;James P. Snyder

  184
  Citations

• The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity.

  Simak Ali;Dean A. Heathcote;Sebastian H.B. Kroll;Ashutosh S. Jogalekar

  182
  Citations

• Bridging of macrodithionolactones to bicyclic systems. Synthesis and modeling of oxapolycyclic frameworks

  K. C. Nicolaou;C. K. Hwang;B. E. Marron;S. A. DeFrees

  159
  Citations

• EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1.

  Shala L. Thomas;Diansheng Zhong;Wei Zhou;Sanna Malik

  159
  Citations

• The bioactive Taxol conformation on β-tubulin: Experimental evidence from highly active constrained analogs

  Thota Ganesh;Rebecca C. Guza;Susan Bane;Rudravajhala Ravindra

  150
  Citations

• Discovery of small molecule CXCR4 antagonists.

  Weiqiang Zhan;Zhongxing Liang;Aizhi Zhu;Serdar Kurtkaya

  149
  Citations

• 13C Kinetic Isotope Effects for the Addition of Lithium Dibutylcuprate to Cyclohexenone. Reductive Elimination Is Rate-Determining

  Doug E. Frantz;Daniel A. Singleton;James P. Snyder

  145
  Citations