World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
15938
World Ranking
10670
National Ranking
816

Overview

Simak Ali is affiliated with Imperial College London in the United Kingdom. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a substantial focus on Molecular Biology and Oncology.

Their work encompasses several subfields including Pulmonary and Respiratory Medicine, Cancer Research, and Genetics. Key topics addressed in their research include Advanced Breast Cancer Therapies, Cancer Genomics and Diagnostics, Cancer-related Molecular Pathways, Ubiquitin and Proteasome Pathways, Cancer Cells and Metastasis, Genomics and Chromatin Dynamics, and Estrogen and Related Hormone Effects.

Among Simak Ali's recent papers are:

  • "CDK7 inhibitors as anticancer drugs," 2020, Cancer and Metastasis Reviews
  • "Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis," 2022, Cancer Research
  • "ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation," 2022, Nature Communications
  • "Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence," 2022, Nature Communications
  • "Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib," 2023, Nature Communications

The scientist has collaborated frequently with other researchers, including:

  • R. Charles Coombes
  • Jacqui Shaw
  • Carlo Palmieri
  • Manikandan Periyasamy
  • Rebecca C. Allsopp

Simak Ali's publications have appeared in multiple venues, with notable contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Communications
  • Oncogene
  • JCO Precision Oncology

Best Publications

  • Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.

    Robert A. Campbell;Poornima Bhat-Nakshatri;Nikhil M. Patel;Demetra Constantinidou

  • Endocrine-responsive breast cancer and strategies for combating resistance.

    Simak Ali;R. Charles Coombes

  • Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

    Simak Ali;D. Metzger;J.-M. Bornert;P. Chambon

  • Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.

    D M Vigushin;S Ali;P E Pace;N Mirsaidi

  • Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

    Suzanne A. Eccles;Eric O. Aboagye;Simak Ali;Annie S. Anderson

  • Personalized Detection of Circulating Tumor DNA Antedates Breast Cancer Metastatic Recurrence

    Raoul Charles Coombes;Karen Page;Raheleh Salari;Robert K. Hastings

  • Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha.

    P Pace;J Taylor;S Suntharalingam;R C Coombes

  • Estrogen receptor alpha in human breast cancer: occurrence and significance.

    S Ali;R C Coombes

  • Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifen

    Antoni Hurtado;Kelly A. Holmes;Timothy R. Geistlinger;Iain Robert Hutcheson

  • Enhanced Estrogen Receptor (ER) α, ERBB2, and MAPK Signal Transduction Pathways Operate during the Adaptation of MCF-7 Cells to Long Term Estrogen Deprivation

    Lesley-Ann Martin;Ian Farmer;Stephen R.D. Johnston;Simak Ali

  • Activation of Estrogen Receptor α by S118 Phosphorylation Involves a Ligand-Dependent Interaction with TFIIH and Participation of CDK7

    Dongsheng Chen;Thilo Riedl;Elinor Washbrook;Paul E. Pace

  • Phosphorylation of Human Estrogen Receptor α by Protein Kinase A Regulates Dimerization

    Dongsheng Chen;Paul E. Pace;R. Charles Coombes;Simak Ali

  • Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells

    Daniel Metzger;Simak Ali;Jean-Marc Bornert;Pierre Chambon

  • Phosphorylation of human estrogen receptor α at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera

    Dongsheng Chen;Elinor Washbrook;Naveed Sarwar;Gaynor J. Bates

  • Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: a double-blind placebo-controlled phase II randomised trial.

    Andreas Polychronis;H Dudley Sinnett;Dimitri Hadjiminas;Hemant Singhal

  • Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts

    Jacqueline A. Shaw;David S. Guttery;A. Hills;Daniel Fernandez-Garcia

  • A Common Deletion in the APOBEC3 Genes and Breast Cancer Risk

    Jirong Long;Ryan J. Delahanty;Guoliang Li;Yu-Tang Gao

  • Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation.

    Christina M.W Chan;Lesley-Ann Martin;Stephen R.D Johnston;Simak Ali

  • Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-α activity

    Ross S Thomas;Naveed Sarwar;Fladia Phoenix;R Charles Coombes

  • Immunohistochemical determination of estrogen receptor-alpha phosphorylation in activation function AF1 in primary and tamoxifen-resistant breast cancer is indicative of a complex role for estrogen receptor-alpha phosphorylation in breast cancer progression [Abstract]

    S. Ali;N. Sarwar;J. Jiang;D. Peston

Frequent Co-Authors

R. Charles Coombes
R. Charles Coombes Imperial College London
Anthony G. M. Barrett
Anthony G. M. Barrett Imperial College London
Matthew J. Fuchter
Matthew J. Fuchter Imperial College London
Jason S. Carroll
Jason S. Carroll University of Cambridge
Emad A. Rakha
Emad A. Rakha University of Nottingham
James P. Snyder
James P. Snyder Emory University
Ian O. Ellis
Ian O. Ellis University of Nottingham
Justin Stebbing
Justin Stebbing Imperial College London
Pierre Chambon
Pierre Chambon Institute of Genetics and Molecular and Cellular Biology
Andrew R. Green
Andrew R. Green University of Nottingham

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