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Medicine

D-Index
98
Citations
48936
World Ranking
8773
National Ranking
855

Overview

R. Charles Coombes is affiliated with Imperial College London in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Subfields of particular focus include Molecular Biology, Oncology, Cancer Research, Pulmonary and Respiratory Medicine, and Immunology.

The scientist's work covers several main topics, including Cancer Genomics and Diagnostics, Advanced Breast Cancer Therapies, Cancer Cells and Metastasis, Neutrophil, Myeloperoxidase and Oxidative Mechanisms, Genetic Factors in Colorectal Cancer, Immune Cells in Cancer, and Cancer-related Molecular Pathways.

Frequent collaborators with R. Charles Coombes comprise: Simak Ali, Jacqui Shaw, Karen Page, Carlo Palmieri, and Rebecca C. Allsopp.

Publishing regularly, some of their notable recent papers are:

  • "Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer," 2022, Nature Communications
  • "Extracellular vesicles as a promising source of lipid biomarkers for breast cancer detection in blood plasma," 2024, Journal of Extracellular Vesicles
  • "Single Particle Automated Raman Trapping Analysis of Breast Cancer Cell-Derived Extracellular Vesicles as Cancer Biomarkers," 2021, ACS Nano
  • "A Review of Circulating Tumour Cell Enrichment Technologies," 2021, Cancers
  • "CDK7 inhibitors as anticancer drugs," 2020, Cancer and Metastasis Reviews

R. Charles Coombes has published multiple articles in several specific venues, including:

  • Annals of Oncology
  • Cancer Research
  • Nature Communications
  • Breast Cancer Research and Treatment
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials

    O. Abe;R. Abe;K. Enomoto;K. Kikuchi

  • Polychemotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group.

    C Focan;SM Steinberg;M Blichert-Toft;JF Forbes

  • Assessment of Ki67 in Breast Cancer: Recommendations from the International Ki67 in Breast Cancer Working Group

    Mitch Dowsett;Torsten O. Nielsen;Roger A’Hern;John Bartlett

  • A pooled analysis of bone marrow micrometastasis in breast cancer

    Stephan Braun;Florian D. Vogl;Bjørn Naume;Wolfgang Janni

  • Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial.

    Nicola M. Neary;Caroline J. Small;Alison M. Wren;Jennifer L. Lee

  • Triple-negative breast cancer: therapeutic options

    Susan Cleator;Susan Cleator;Wolfgang Heller;R Charles Coombes;R Charles Coombes

  • Endocrine-responsive breast cancer and strategies for combating resistance.

    Simak Ali;R. Charles Coombes

  • Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials

    Bernard Asselain;William Barlow;John Bartlett;Jonas Bergh

  • A Phase I Study of OncoVEXGM-CSF, a Second-Generation Oncolytic Herpes Simplex Virus Expressing Granulocyte Macrophage Colony-Stimulating Factor

    Jennifer C.C. Hu;Robert S. Coffin;Ceri J. Davis;Nicola J. Graham

  • FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

    Andrew Sunters;Silvia Fernández de Mattos;Marie Stahl;Jan J. Brosens

  • Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis

    Scott P. Fraser;James K.J. Diss;Athina-Myrto Chioni;Maria E. Mycielska

  • Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.

    D M Vigushin;S Ali;P E Pace;N Mirsaidi

  • Skeletal effects of exemestane on bone-mineral density, bone biomarkers, and fracture incidence in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): a randomised controlled study

    Robert E Coleman;Linda M Banks;Samia I Girgis;Lucy S Kilburn

  • Personalized Detection of Circulating Tumor DNA Antedates Breast Cancer Metastatic Recurrence

    Raoul Charles Coombes;Karen Page;Raheleh Salari;Robert K. Hastings

  • Estrogen receptor alpha in human breast cancer: occurrence and significance.

    S Ali;R C Coombes

  • The estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response

    Leandro Castellano;Georgios Giamas;Jimmy Jacob;R. Charles Coombes

  • Phase I Trial of the Positron-Emitting Arg-Gly-Asp (RGD) Peptide Radioligand 18F-AH111585 in Breast Cancer Patients

    Laura M. Kenny;R. Charles Coombes;Inger Oulie;Kaiyumars B. Contractor

  • Imaging early changes in proliferation at 1 week post chemotherapy: a pilot study in breast cancer patients with 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography.

    Laura Kenny;R. Charles Coombes;David M. Vigushin;Adil Al-Nahhas

  • Activation of Estrogen Receptor α by S118 Phosphorylation Involves a Ligand-Dependent Interaction with TFIIH and Participation of CDK7

    Dongsheng Chen;Thilo Riedl;Elinor Washbrook;Paul E. Pace

  • Immunohistochemical determination of estrogen receptor-alpha phosphorylation in activation function AF1 in primary and tamoxifen-resistant breast cancer is indicative of a complex role for estrogen receptor-alpha phosphorylation in breast cancer progression [Abstract]

    S. Ali;N. Sarwar;J. Jiang;D. Peston

Frequent Co-Authors

Simak Ali
Simak Ali Imperial College London
Justin Stebbing
Justin Stebbing Imperial College London
Eric Lam
Eric Lam Sun Yat-sen University
Judith M. Bliss
Judith M. Bliss Institute of Cancer Research
Anthony G. M. Barrett
Anthony G. M. Barrett Imperial College London
Ian O. Ellis
Ian O. Ellis University of Nottingham
Jacqui A. Shaw
Jacqui A. Shaw University of Leicester
Robert E. Coleman
Robert E. Coleman University of Sheffield
Matthew J. Fuchter
Matthew J. Fuchter Imperial College London
Andrew R. Green
Andrew R. Green University of Nottingham

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