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Pierre-Marie Lledo

Pierre-Marie Lledo

D-Index & Metrics

Neuroscience

D-Index
78
Citations
22977
World Ranking
1760
National Ranking
57

Overview

Pierre-Marie Lledo is affiliated with the Institut Pasteur in France. Their primary research focuses on the intersection of neuroscience and medicine, with significant contributions to subfields including neurology, sensory systems, cellular and molecular neuroscience, psychiatry and mental health, and molecular biology.

The scientist's main topics of work encompass olfactory and sensory function studies, neuroinflammation and neurodegeneration mechanisms, vagus nerve stimulation research, bipolar disorder and treatment, tryptophan and brain disorders, neuroendocrine regulation and behavior, and the long-term effects of COVID-19.

Frequent coauthors in their research include Gabriel Lepousez, Mariana Alonso, Françoise Lazarini, Marc Lecuit, and Chantal Henry. Their publications are regularly found in journals such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, La Revue de Médecine Interne, Cell Reports, and Molecular Psychiatry.

Notable recent papers include the following:

  • "COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters," 2021, Science Translational Medicine
  • "Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system," 2020, Nature Communications
  • "Bacterial sensing via neuronal Nod2 regulates appetite and body temperature," 2022, Science
  • "Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine," 2020, Cell Reports
  • "Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice," 2023, Molecular Psychiatry

Their body of work demonstrates an ongoing engagement with the molecular and cellular mechanisms underlying brain function and behavior, incorporating diverse methodologies and experimental models.

Pierre-Marie Lledo's contributions span 63 publications in neuroscience and 48 in medicine, reflecting a broad interdisciplinary approach within these scientific domains.

Best Publications

  • Adult neurogenesis and functional plasticity in neuronal circuits

    Pierre-Marie Lledo;Mariana Alonso;Matthew S. Grubb

  • Becoming a new neuron in the adult olfactory bulb

    Alan Carleton;Leopoldo T. Petreanu;Rusty Lansford;Arturo Alvarez-Buylla

  • Enriched Odor Exposure Increases the Number of Newborn Neurons in the Adult Olfactory Bulb and Improves Odor Memory

    Christelle Rochefort;Gilles Gheusi;Jean Didier Vincent;Pierre Marie Lledo

  • Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

    Morgane Sonia Thion;Donovan Low;Aymeric Silvin;Jinmiao Chen

  • Neuronal fate determinants of adult olfactory bulb neurogenesis.

    Michael A Hack;Armen Saghatelyan;Antoine de Chevigny;Alexander Pfeifer

  • Importance of newly generated neurons in the adult olfactory bulb for odor discrimination

    Gilles Gheusi;Harold Cremer;Heather McLean;Geneviève Chazal

  • Postsynaptic membrane fusion and long-term potentiation

    Pierre-Marie Lledo;Xiangyang Zhang;Thomas C. Südhof;Robert C. Malenka

  • Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism

    Pierre Marie Lledo;Gregory O. Hjelmstad;Sucheta Mukherji;Thomas R. Soderling

  • Origin and function of olfactory bulb interneuron diversity

    Pierre-Marie Lledo;Florian T. Merkle;Florian T. Merkle;Arturo Alvarez-Buylla

  • Information Processing in the Mammalian Olfactory System

    Pierre-Marie Lledo;Gilles Gheusi;Jean-Didier Vincent

  • COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters.

    Guilherme Dias de Melo;Françoise Lazarini;Sylvain Levallois;Sylvain Levallois;Charlotte Hautefort

  • Is adult neurogenesis essential for olfaction

    Françoise Lazarini;Pierre-Marie Lledo;Pierre-Marie Lledo

  • Integrating new neurons into the adult olfactory bulb: joining the network, life–death decisions, and the effects of sensory experience

    Pierre-Marie Lledo;Armen Saghatelyan

  • Olfactory discrimination learning increases the survival of adult-born neurons in the olfactory bulb.

    Mariana Alonso;Cécile Viollet;Marie-Madeleine Gabellec;Vannary Meas-Yedid

  • Control of action potential timing by intrinsic subthreshold oscillations in olfactory bulb output neurons.

    David Desmaisons;Jean-Didier Vincent;Pierre-Marie Lledo

  • Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus

    Pierre-Marie Lledo;Patrick Tremblay;Stephen J. Dearmond;Stanley B. Prusiner

  • Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

    Grégoire Chevalier;Eleni Siopi;Laure Guenin-Macé;Maud Pascal

  • The endocannabinoid system controls food intake via olfactory processes

    Edgar Soria-Gómez;Luigi Bellocchio;Leire Reguero;Gabriel Lepousez

  • Adult neurogenesis promotes synaptic plasticity in the olfactory bulb

    Antoine Nissant;Cedric Bardy;Hiroyuki Katagiri;Kerren Murray

  • Neonatal and Adult Neurogenesis Provide Two Distinct Populations of Newborn Neurons to the Mouse Olfactory Bulb

    Morgane Lemasson;Armen Saghatelyan;Jean-Christophe Olivo-Marin;Pierre-Marie Lledo

  • Interplay between Local GABAergic Interneurons and Relay Neurons Generates γ Oscillations in the Rat Olfactory Bulb

    Samuel Lagier;Alan Carleton;Pierre-Marie Lledo

Frequent Co-Authors

Gilles Gheusi
Gilles Gheusi Institut Pasteur
Marco Sassoè-Pognetto
Marco Sassoè-Pognetto University of Turin
Alan Carleton
Alan Carleton University of Geneva
Arturo Alvarez-Buylla
Arturo Alvarez-Buylla University of California, San Francisco
Jean-Didier Vincent
Jean-Didier Vincent Centre national de la recherche scientifique, CNRS
Marc Lecuit
Marc Lecuit Institut Pasteur
Ivo G. Boneca
Ivo G. Boneca Institut Pasteur
Harry Sokol
Harry Sokol Sorbonne University
Caroline Demangel
Caroline Demangel Institut Pasteur
Marion Leboyer
Marion Leboyer Paris-Est Créteil University

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