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Neuroscience

D-Index
66
Citations
23698
World Ranking
2958
National Ranking
21

Overview

Ludwig Aigner is affiliated with Paracelsus Medical University in Austria and has a substantial body of research primarily in the fields of medicine and neuroscience. Their work encompasses various subfields including neurology, physiology, molecular biology, pathology and forensic medicine, as well as public health, environmental and occupational health.

The main topics addressed in Aigner's research include:

  • Neuroinflammation and neurodegeneration mechanisms
  • Spinal cord injury research
  • Alzheimer's disease research and treatments
  • Diet and metabolism studies
  • Tryptophan and brain disorders
  • Neurogenesis and neuroplasticity mechanisms
  • Neurogenetic and muscular disorders research

Aigner has published extensively in a range of scientific journals. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Neuroscience
  • International Journal of Molecular Sciences
  • Neurotherapeutics

Several of Aigner's recent papers, which have attracted notable academic citations, exemplify the focus areas of their research:

  • Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain (2020, Nature Neuroscience)
  • Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease (2020, Nature)
  • CD8+ T-cells infiltrate Alzheimer's disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice (2020, Brain Behavior and Immunity)
  • Neuroinflammation in Alzheimer disease (2024, Nature reviews. Immunology)
  • CD4 + T cells contribute to neurodegeneration in Lewy body dementia (2021, Science)

Aigner collaborates frequently with a core group of coauthors, among whom are:

  • Barbara Altendorfer
  • Michael S. Unger
  • Heike Mrowetz
  • Diana M Bessa de Sousa
  • Iris Leister

Best Publications

  • The ageing systemic milieu negatively regulates neurogenesis and cognitive function

    Saul A. Villeda;Jian Luo;Kira I. Mosher;Bende Zou

  • Transient expression of doublecortin during adult neurogenesis

    Jason P. Brown;Sébastien Couillard-Després;Christiana M. Cooper-Kuhn;Jürgen Winkler;Jürgen Winkler

  • CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles.

    Dagmar Beier;Peter Hau;Martin A. Proescholdt;Annette Lohmeier

  • Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper

    Thomas Lener;Mario Gimona;Ludwig Aigner;Verena Börger

  • Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

    Julia Marschallinger;Julia Marschallinger;Tal Iram;Macy Zardeneta;Song E. Lee

  • Doublecortin expression levels in adult brain reflect neurogenesis.

    Sebastien Couillard-Despres;Beate Winner;Susanne Schaubeck;Robert Aigner

  • Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

    David Gate;David Gate;Naresha Saligrama;Olivia Leventhal;Andrew C. Yang

  • Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice.

    Ludwig Aigner;Silvia Arber;Josef P. Kapfhammer;Thorsten Laux

  • Human Adult Neurogenesis: Evidence and Remaining Questions.

    Gerd Kempermann;Fred H. Gage;Ludwig Aigner;Hongjun Song

  • Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells

    A Di Polo;L J Aigner;R J Dunn;G M Bray

  • Direct Stimulation of Adult Neural Stem Cells In Vitro and Neurogenesis In Vivo by Vascular Endothelial Growth Factor

    Anne Schänzer;Frank-Peter Wachs;Daniel Wilhelm;Till Acker

  • High efficacy of clonal growth and expansion of adult neural stem cells.

    Frank-Peter Wachs;Sebastien Couillard-Despres;Maren Engelhardt;Daniel Wilhelm;Daniel Wilhelm

  • Adult neural progenitor cell grafts survive after acute spinal cord injury and integrate along axonal pathways.

    Maurice Vroemen;Ludwig Aigner;Juergen Winkler;Juergen Winkler;Norbert Weidner

  • Brain and Retinal Pericytes: Origin, Function and Role

    Andrea Trost;Simona Lange;Falk Schroedl;Daniela Bruckner

  • Absence of persistent spreading, branching, and adhesion in GAP-43-depleted growth cones.

    Ludwig Aigner;Pico Caroni

  • Depletion of 43-kD growth-associated protein in primary sensory neurons leads to diminished formation and spreading of growth cones.

    L Aigner;P Caroni

  • CD8+ T-cells infiltrate Alzheimer's disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice.

    M S Unger;E Li;L Scharnagl;R Poupardin

  • Gene Expression Profiling of Neural Stem Cells and Their Neuronal Progeny Reveals IGF2 as a Regulator of Adult Hippocampal Neurogenesis

    Oliver Bracko;Tatjana Singer;Stefan Aigner;Marlen Knobloch

  • Transforming growth factor-beta1 is a negative modulator of adult neurogenesis.

    Frank-Peter Wachs;Beate Winner;Beate Winner;Sebastien Couillard-Despres;Sebastien Couillard-Despres;Thorsten Schiller;Thorsten Schiller

  • Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

    Julia Marschallinger;Iris Schäffner;Barbara Klein;Renate Gelfert

  • Mesenchymal Stem Cells Instruct Oligodendrogenic Fate Decision on Adult Neural Stem Cells

    Francisco J. Rivera;Francisco J. Rivera;Sebastien Couillard-Despres;Xiomara Pedre;Sonja Ploetz

  • Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain

    Julia Marschallinger;Julia Marschallinger;Tal Iram;Macy Zardeneta;Song E. Lee

Frequent Co-Authors

Sebastien Couillard-Despres
Sebastien Couillard-Despres Paracelsus Medical University
Beate Winner
Beate Winner University of Erlangen-Nuremberg
Jürgen Winkler
Jürgen Winkler University of Erlangen-Nuremberg
Sandrine Thuret
Sandrine Thuret King's College London
H. Georg Kuhn
H. Georg Kuhn University of Gothenburg
Eugen Trinka
Eugen Trinka Paracelsus Medical University
Eliezer Masliah
Eliezer Masliah National Institutes of Health
Paul J. Lucassen
Paul J. Lucassen University of Amsterdam
Michael T. Heneka
Michael T. Heneka University Hospital Bonn
Edward Rockenstein
Edward Rockenstein University of California, San Diego

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