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Biology and Biochemistry

D-Index
44
Citations
7594
World Ranking
19282
National Ranking
673

Overview

Wanyin Deng is affiliated with the University of British Columbia in Canada and conducts research primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine.

Their work focuses on various subfields, including Endocrinology, Molecular Biology, Genetics, Pulmonary and Respiratory Medicine, and Food Science. The main research topics covered by their studies include Vibrio bacteria research, Escherichia coli research, Bacterial Genetics and Biotechnology, gut microbiota and health, Salmonella and Campylobacter epidemiology, bacterial biofilms and quorum sensing, and bacteriophages and microbial interactions.

Wanyin Deng has published numerous papers, some of which include:

  • "Type VI secretion systems of pathogenic and commensal bacteria mediate niche occupancy in the gut," 2022, Cell Reports
  • "Quantitative proteomic screen identifies annexin A2 as a host target for Salmonella pathogenicity island-2 effectors SopD2 and PipB2," 2021, Scientific Reports
  • "Cryo-EM structure of the EspA filament from enteropathogenic Escherichia coli: Revealing the mechanism of effector translocation in the T3SS," 2021, Structure
  • "Structural and Cellular Insights into the l, d-Transpeptidase YcbB as a Therapeutic Target in Citrobacter rodentium, Salmonella Typhimurium, and Salmonella Typhi Infections," 2020, Antimicrobial Agents and Chemotherapy
  • "Quorum sensing modulates bacterial virulence and colonization dynamics of the gastrointestinal pathogen Citrobacter rodentium," 2023, Gut Microbes

Their frequent coauthors include B. Brett Finlay, Antonio Serapio-Palacios, Sarah E. Woodward, Anna Creus-Cuadros, and Zakhar Krekhno.

Wanyin Deng's research has appeared in a variety of publication venues with multiple contributions to bioRxiv (Cold Spring Harbor Laboratory), along with papers published in Cell Reports, Scientific Reports, Gut Microbes, and Structure.

Best Publications

  • Dissecting virulence: Systematic and functional analyses of a pathogenicity island

    Wanyin Deng;José L. Puente;Samantha Gruenheid;Yuling Li

  • Assembly, structure, function and regulation of type III secretion systems

    Wanyin Deng;Natalie C. Marshall;Jennifer L. Rowland;James M. McCoy

  • Locus of Enterocyte Effacement from Citrobacter rodentium: Sequence Analysis and Evidence for Horizontal Transfer among Attaching and Effacing Pathogens

    Wanyin Deng;Yuling Li;Bruce A. Vallance;B. Brett Finlay

  • Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7.

    Samantha Gruenheid;Inna Sekirov;Nikhil A. Thomas;Wanyin Deng

  • A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system

    Thomas Spreter;Calvin K Yip;Calvin K Yip;Sarah Sanowar;Ingemar André

  • Attaching and effacing pathogen-induced tight junction disruption in vivo.

    Julian A. Guttman;Yuling Li;Mark E. Wickham;Wanyin Deng

  • Citrobacter rodentium translocated intimin receptor (Tir) is an essential virulence factor needed for actin condensation, intestinal colonization and colonic hyperplasia in mice.

    Wanyin Deng;Bruce A. Vallance;Yuling Li;Jose L. Puente

  • Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium.

    Bruce A. Vallance;Wanyin Deng;Kevan Jacobson;B. Brett Finlay

  • Regulation of Type III Secretion Hierarchy of Translocators and Effectors in Attaching and Effacing Bacterial Pathogens

    Wanyin Deng;Yuling Li;Philip R. Hardwidge;Elizabeth A. Frey

  • Toll-Like Receptor 4 Contributes to Colitis Development but Not to Host Defense during Citrobacter rodentium Infection in Mice

    Mohammed A. Khan;Caixia Ma;Leigh A. Knodler;Yanet Valdez;Yanet Valdez

  • Bacterial Effector Binding to Ribosomal Protein S3 Subverts NF-κB Function

    Xiaofei Gao;Fengyi Wan;Kristina Mateo;Eduardo Callegari

  • A Positive Regulatory Loop Controls Expression of the Locus of Enterocyte Effacement-Encoded Regulators Ler and GrlA

    Jeannette Barba;Víctor H. Bustamante;Mario A. Flores-Valdez;Wanyin Deng

  • Structural analysis of a prototypical ATPase from the type III secretion system.

    Raz Zarivach;Marija Vuckovic;Wanyin Deng;B Brett Finlay

  • Mice Lacking T and B Lymphocytes Develop Transient Colitis and Crypt Hyperplasia yet Suffer Impaired Bacterial Clearance during Citrobacter rodentium Infection

    Bruce A. Vallance;Wanyin Deng;Leigh A. Knodler;B. Brett Finlay

  • CesT is a multi-effector chaperone and recruitment factor required for the efficient type III secretion of both LEE- and non-LEE-encoded effectors of enteropathogenic Escherichia coli.

    Nikhil A. Thomas;Wanyin Deng;Jose L. Puente;Jose L. Puente;Elizabeth A. Frey

  • Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens.

    Julian A Guttman;Fereshte N Samji;Yuling Li;Wanyin Deng

  • Agrobacterium VirD2 protein interacts with plant host cyclophilins

    Wanyin Deng;Lishan Chen;Derek W. Wood;Tracee Metcalfe

  • Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map).

    Caixia Ma;Mark E. Wickham;Julian A. Guttman;Wanyin Deng

  • Role of inflammasomes in host defense against Citrobacter rodentium infection.

    Zhiping Liu;Md. Hasan Zaki;Peter Vogel;Prajwal Gurung

  • Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS

    Raz Zarivach;Wanyin Deng;Marija Vuckovic;Heather B. Felise

Frequent Co-Authors

B. Brett Finlay
B. Brett Finlay University of British Columbia
José L. Puente
José L. Puente National Autonomous University of Mexico
Bruce A. Vallance
Bruce A. Vallance University of British Columbia
Natalie C. J. Strynadka
Natalie C. J. Strynadka University of British Columbia
Eugene W. Nester
Eugene W. Nester University of Washington
Leonard J. Foster
Leonard J. Foster University of British Columbia
Brian K. Coombes
Brian K. Coombes McMaster University
Milton P. Gordon
Milton P. Gordon University of Washington
Yoshimi Takai
Yoshimi Takai Kobe University
A. Wayne Vogl
A. Wayne Vogl University of British Columbia

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