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Biology and Biochemistry

D-Index
50
Citations
9218
World Ranking
17625
National Ranking
7229

Overview

Gail Hecht is affiliated with Loyola University Chicago in the United States. Their research primarily focuses on medical and biological sciences, with a strong emphasis on infectious diseases, gastroenterology, and molecular biology.

Their work spans several main fields of study:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these fields, their research concentrates on specific subfields, including:

  • Infectious Diseases
  • Gastroenterology
  • Molecular Biology
  • Endocrinology
  • Epidemiology

The principal topics covered in their publications encompass:

  • Clostridium difficile and Clostridium perfringens research
  • Gastrointestinal motility and disorders
  • Gut microbiota and health
  • Microscopic Colitis
  • Escherichia coli research studies
  • Viral gastroenteritis research and epidemiology
  • Probiotics and Fermented Foods

Gail Hecht has contributed to multiple articles in well-regarded publication venues, with frequent appearances in:

  • Gastroenterology
  • Open Forum Infectious Diseases
  • Gut Microbes
  • The American Journal of Gastroenterology
  • BMC Infectious Diseases

Recent papers authored or co-authored by Gail Hecht include:

  • Durable reduction of Clostridioides difficile infection recurrence and microbiome restoration after treatment with RBX2660: results from an open-label phase 2 clinical trial, 2022, BMC Infectious Diseases
  • The Efficacy and Safety of Fecal Microbiota Transplant for Recurrent Clostridiumdifficile Infection: Current Understanding and Gap Analysis, 2020, Open Forum Infectious Diseases
  • Transmission of the Potential Pathogen Atypical Enteropathogenic Escherichia coli by Fecal Microbiota Transplant, 2023, Gastroenterology
  • Clinical Manifestations and Stool Load of Atypical Enteropathogenic Escherichia coli Infections in United States Children and Adults, 2022, Gastroenterology
  • Recommendations to Improve Quality of Probiotic Systematic Reviews With Meta-Analyses, 2023, JAMA Network Open

The scientist frequently collaborates with several co-authors, including:

  • Sarah E. Kralicek
  • Majdi Osman
  • Lalitha Sitaraman
  • Robert Orenstein
  • Rocío Tapia

Best Publications

  • Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation

    J Berkes;V K Viswanathan;S D Savkovic;G Hecht

  • Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers.

    G Hecht;C Pothoulakis;J T LaMont;J L Madara

  • A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease

    Yevgeny Zolotarevsky;Gail Hecht;Athanasia Koutsouris;Deborah E. Gonzalez

  • Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function

    Barry P. McNamara;Athanasia Koutsouris;Colin B. O’Connell;Jean-Philippe Nougayréde

  • Activation of NF-κB in intestinal epithelial cells by enteropathogenic Escherichia coli

    Suzana D. Savkovic;Athanasia Koutsouris;Gail Hecht

  • Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability

    R Yuhan;A Koutsouris;SD Savkovic;G Hecht

  • Clostridium difficile toxin B disrupts the barrier function of T84 monolayers

    Gail Hecht;Athanasia Koutsouris;Charalabos Pothoulakis;J.Thomas LaMont

  • The intestinal microbiome, probiotics and prebiotics in neurogastroenterology

    Delphine M. Saulnier;Yehuda Ringel;Melvin B. Heyman;Jane A. Foster

  • Attachment of a noninvasive enteric pathogen, enteropathogenic Escherichia coli, to cultured human intestinal epithelial monolayers induces transmigration of neutrophils.

    S D Savkovic;A Koutsouris;G Hecht

  • Enteropathogenic Escherichia coli infection leads to appearance of aberrant tight junctions strands in the lateral membrane of intestinal epithelial cells

    Michelle M. Muza-Moons;Eveline E. Schneeberger;Gail A. Hecht

  • Enteropathogenic E. coli disrupts tight junction barrier function and structure in vivo

    Donnie E Shifflett;Daniel R Clayburgh;Athanasia Koutsouris;Jerrold R Turner

  • Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability

    Gail Hecht;Lidija Pestic;Gordana Nikcevic;Athanasia Koutsouris

  • The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways

    Neal M. Alto;Andrew W. Weflen;Matthew J. Rardin;Defne Yarar

  • Mechanism underlying inhibition of intestinal apical Cl–/OH– exchange following infection with enteropathogenic E. coli

    Ravinder K. Gill;Alip Borthakur;Kim Hodges;Jerrold R. Turner

  • Comparative Analysis of EspF from Enteropathogenic and Enterohemorrhagic Escherichia coli in Alteration of Epithelial Barrier Function

    V. K. Viswanathan;Athanasia Koutsouris;Sandra Lukic;Mark Pilkinton

  • Enteropathogenic Escherichia coli EspG disrupts microtubules and in conjunction with Orf3 enhances perturbation of the tight junction barrier.

    Farol L. Tomson;V. K. Viswanathan;Kristen J. Kanack;Rajani P. Kanteti

  • Enterohemorrhagic E. coli alters murine intestinal epithelial tight junction protein expression and barrier function in a Shiga toxin independent manner

    Jennifer Lising Roxas;Athanasia Koutsouris;Amy Bellmeyer;Samuel Tesfay

  • Differential regulation of Na+/H+ exchange isoform activities by enteropathogenic E. coli in human intestinal epithelial cells

    Gail Hecht;Kim Hodges;Ravinder K. Gill;Fely Kear

  • Stabilization of F-actin prevents cAMP-elicited Cl- secretion in T84 cells.

    M Shapiro;J Matthews;G Hecht;C Delp

  • The bacterial virulence factor NleA is required for the disruption of intestinal tight junctions by enteropathogenic Escherichia coli.

    Ajitha Thanabalasuriar;Athanasia Koutsouris;Andrew Weflen;Mark Mimee

Frequent Co-Authors

Pradeep K. Dudeja
Pradeep K. Dudeja University of Illinois at Chicago
Erik R. Dubberke
Erik R. Dubberke Washington University in St. Louis
Jerrold R. Turner
Jerrold R. Turner Brigham and Women's Hospital
Dale N. Gerding
Dale N. Gerding Veterans Health Administration
John M. Leong
John M. Leong Tufts University
Mark H. Wilcox
Mark H. Wilcox University of Leeds
James B. Kaper
James B. Kaper University of Maryland, Baltimore
Michael S. Donnenberg
Michael S. Donnenberg Virginia Commonwealth University
Herbert L. DuPont
Herbert L. DuPont The University of Texas Health Science Center at Houston
Phillip I. Tarr
Phillip I. Tarr Washington University in St. Louis

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