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Genetics

D-Index
70
Citations
23261
World Ranking
2247
National Ranking
281

Overview

William C. Skarnes is affiliated with the Wellcome Sanger Institute in the United Kingdom. Their research primarily centers on the fields of Biochemistry, Genetics, and Molecular Biology, with a focused involvement in subfields such as Molecular Biology and Genetics.

Their work covers a range of topics including CRISPR and Genetic Engineering, Animal Genetics and Reproduction, Genomics and Chromatin Dynamics, RNA and protein synthesis mechanisms, Molecular Biology Techniques and Applications, Single-cell and spatial transcriptomics, and Virus-based gene therapy research.

William C. Skarnes has contributed to several peer-reviewed publications. Notable papers include:

  • A resource of targeted mutant mouse lines for 5,061 genes, 2021, Nature Genetics
  • MorPhiC Consortium: towards functional characterization of all human genes, 2025, Nature
  • Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines, 2024, Scientific Reports
  • Impact of Essential Genes on the Success of Genome Editing Experiments Generating 3,313 New Genetically Engineered Mouse Lines, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • The Knockout Mouse Project, 2020, UNC Libraries

Frequent co-authors of Skarnes include Allan Bradley, Marie-Christine Birling, David J. Adams, Steve D. M. Brown, and Gemma Codner. Their collaboration spans multiple publications reflecting ongoing partnerships in related research areas.

Skarnes' work has appeared in various scientific venues such as Nature Genetics, Nature, Scientific Reports, bioRxiv (Cold Spring Harbor Laboratory), and UNC Libraries, illustrating a range of dissemination channels for their research findings.

Best Publications

  • A conditional knockout resource for the genome-wide study of mouse gene function.

    William C. Skarnes;Barry Rosen;Anthony P. West;Manousos Koutsourakis

  • Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system

    Tito Serafini;Sophia A Colamarino;E.David Leonardo;Hao Wang

  • An LDL-receptor-related protein mediates Wnt signalling in mice.

    Kathleen I. Pinson;Jane Brennan;Jane Brennan;Susan Monkley;Susan Monkley;Brian J. Avery

  • High-throughput discovery of novel developmental phenotypes

    Mary E. Dickinson;Ann M. Flenniken;Xiao Ji;Lydia Teboul

  • Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.

    Bin Shen;Wensheng Zhang;Jun Zhang;Jiankui Zhou

  • The knockout mouse project

    Christopher P. Austin;James F. Battey;Allan Bradley;Maja Bucan

  • Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes.

    Achim Gossler;Alexandra L. Joyner;Alexandra L. Joyner;Janet Rossant;Janet Rossant;William C. Skarnes

  • Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

    Jacqueline K White;Anna-Karin Gerdin;Natasha A Karp;Ed Ryder

  • Functional analysis of secreted and transmembrane proteins critical to mouse development.

    Kevin J. Mitchell;Kathy I. Pinson;Olivia G. Kelly;Jane Brennan

  • Defining brain wiring patterns and mechanisms through gene trapping in mice

    Philip A. Leighton;Kevin J. Mitchell;Kevin J. Mitchell;Lisa V. Goodrich;Xiaowei Lu

  • Neuropilin-2 Regulates the Development of Select Cranial and Sensory Nerves and Hippocampal Mossy Fiber Projections

    Hang Chen;Anil Bagri;Joel A Zupicich;Yimin Zou

  • Agouti C57BL/6N embryonic stem cells for mouse genetic resources.

    Stephen J. Pettitt;Qi Liang;Xin Y. Rairdan;Jennifer L. Moran;Jennifer L. Moran

  • Capturing genes encoding membrane and secreted proteins important for mouse development

    William C. Skarnes;Julie E. Moss;Stella M. Hurtley;Rosa S. P. Beddington

  • A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice.

    W C Skarnes;B A Auerbach;A L Joyner

  • ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a.

    Xiaolin Gao;Peri Tate;Ping Hu;Robert Tjian

  • The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.

    Olivia G. Kelly;Kathy I. Pinson;William C. Skarnes

  • Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

    David Landeira;Stephan P A Sauer;Raymond Poot;Maria Dvorkina

  • The mammalian gene function resource: the international knockout mouse consortium

    Allan Bradley;Konstantinos Anastassiadis;Abdelkader Ayadi;James F. Battey

  • The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse

    Peri Tate;William Skarnes;Adrian Bird

  • Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells

    Alexandra L. Joyner;William C. Skarnes;William C. Skarnes;Janet Rossant;Janet Rossant

Frequent Co-Authors

Allan Bradley
Allan Bradley University of Cambridge
Kevin C K Lloyd
Kevin C K Lloyd University of California, Davis
Wolfgang Wurst
Wolfgang Wurst German Center for Neurodegenerative Diseases
Yann Herault
Yann Herault Institute of Genetics and Molecular and Cellular Biology
Steve D.M. Brown
Steve D.M. Brown Medical Research Council
Colin McKerlie
Colin McKerlie Hospital for Sick Children
Damian Smedley
Damian Smedley Queen Mary University of London
Karen P. Steel
Karen P. Steel King's College London
Janet Rossant
Janet Rossant University of Toronto
David J. Adams
David J. Adams Wellcome Sanger Institute

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